Journals / The Anatolian Journal of Cardiology / 2015 / Cilt: 15 - Sayı: 5

Semptomlardan revaskülarizasyona kadar geçen zamanla ilişkili olarak miyokard enfarktüsünde duvar hareket değişiklikleri

Wall motion changes in myocardial infarction in relation to the time elapsed from symptoms until revascularization

Pages
363–370
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

On the other hand, the results of follow-up echocardiography proved that the wall motion improvement was highly dependent on the ischemic time

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Wall motion abnormalities during acute ST-segment elevation myocardial infarction (STEMI) and the improvement after recanalization depend on the conditions of the coronary occlusion.Methods: Fifty-seven patients with first-ever STEMI due to one-artery occlusion, treated with primary PCI, were evaluated.
📊
Key Findings & Data:Area at risk and left ventricular wall motion abnormalities were localized with coronary angiography and echocardiography and then compared in relation to the time elapsed from the onset of symptoms at the time of infarction and at 3 months.
💡
Conclusion & Impact:On the other hand, the results of follow-up echocardiography proved that the wall motion improvement was highly dependent on the ischemic time
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Wall motion abnormalities during acute ST-segment elevation myocardial infarction (STEMI) and the improvement after recanalization depend on the conditions of the coronary occlusion.Methods: Fifty-seven patients with first-ever STEMI due to one-artery occlusion, treated with primary PCI, were evaluated. Area at risk and left ventricular wall motion abnormalities were localized with coronary angiography and echocardiography and then compared in relation to the time elapsed from the onset of symptoms at the time of infarction and at 3 months. Left ventricular diameters and ejection fractions were evaluated in relation to the ischemic time.Results: Three hundred forty-one affected left ventricular segments were detected with angiography, while echocardiography showed 206 segments with motion abnormality. No correlation was found between the regional wall motion index in the area at risk and the time elapsed from the beginning of symptoms. However, the improvement in wall motion abnormalities at the follow-up was dependent on the ischemic time (r=-0.29, p<0.03). The early subgroup showed significant improvement in left ventricular ejection fraction at follow-up (p=0.03), whereas in the late subgroup, a significant increase in left ventricle diameters was observed.Conclusion: Our results first demonstrate in humans that in the early hours from the occlusion of the coronary artery, the extent and severity of the wall motion abnormalities inside the area at risk show large variability without relation to the elapsed time since the onset of symptoms. On the other hand, the results of follow-up echocardiography proved that the wall motion improvement was highly dependent on the ischemic time

Özet

Amaç: Akut ST-segment yükselmeli miyokard infarktüsü (STEMİ) sırasında duvar hareket anormallikleri ve rekanalizasyondan sonra iyileşme koroner oklüzyon koşullarına bağlıdır. Yöntemler: Tek arter oklüzyonu nedeniyle ilk kez STEMİ olan ve primer PKG ile tedavi edilen 57 hasta değerlendirildi. Risk altındaki alan ve sol ventrikül duvarı hareket anormallikleri koroner anjiyografi ve ekokardiyografi ile lokalize edildi, daha sonra enfarktüs sırasında semptomların başlangıcından 3 ay sonraya uzanan sürede zamanla ilişkili olarak karşılaştırıldı. Sol ventrikül çapları ve ejeksiyon fraksiyonları iskemik zamanla ilişkili olarak değerlendirildi. Bulgular: Etkilenen 341 sol ventrikül segmenti anjiyografi ile tespit edildi, ekokardiyografi ise hareket anormalliği olan 206 segment gösterdi. Riskli alandaki bölgesel duvar hareketi indeksi ile semptomların başlangıcından beri geçen süre arasında bir korelasyon bulunmadı. Bununla birlikte, takipte duvar hareketi anormalliklerindeki iyileşme iskemik süreye bağlı idi (r=-0,29, p<0,03). Erken alt grubu takipte sol ventrikül ejeksiyon fraksiyonunda anlamlı düzelme gösterdi (p=0,03), oysa geç alt grubunda sol ventrikül çaplarında önemli artış gözlendi. Sonuç: Çalışmamız öncelikle insanda koroner arter oklüzyonu nedeniyle erken saatlerde riskli bölgede duvar hareket bozukluğunun yaygınlığının ve şiddetinin semptomların başlamasından bu yana geçen süre ile ilişkili olmaksızın büyük değişkenlik gösterdiğini ortaya koymuştur. Öte yandan, takip ekokardiyografi sonuçları duvar hareketindeki düzelmelerin iskemik zamana oldukça bağımlı olduğunu göstermiştir.

🔖

Cite This Article

RÁCZ, I., FÜLÖP, L., KOLOZSVÁRİ, R., SZABÓ, G. T., BÓDİ, A., PÉTER, A., KERTÉSZ, A., HEGEDÜS, I., ÉDES, I., BALKAY, L., KÕSZEGİ, Z. (2015). Semptomlardan revaskülarizasyona kadar geçen zamanla ilişkili olarak miyokard enfarktüsünde duvar hareket değişiklikleri. The Anatolian Journal of Cardiology, Cilt: 15 - Sayı: 5, 363–370. https://ajindex.com/articles/365621

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (6)

  1. Zipes DP, Braunwald E. Braunwald's heart disease: a textbook of cardiovascular medicine: W.B. Saunders; 2005
  2. Cotran RS, Kumar V, Collins T, Robbins SL. Robbins pathologic basis of disease: Saunders; 1999
  3. Reimer KA, Jennings RB. The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 1979; 40: 633-44
  4. Gillam LD, Franklin TD, Foale RA, Wiske PS, Guyer DE, Hogan RD, et al. The natural history of regional wall motion in the acutely infarcted canine ventricle. J Am Coll Cardiol 1986; 7: 1325-34. [CrossRef] 5. Elzbieciak M, Wita K, Grabka M, Chmurawa J, Doruchowska A, Turski M, et al. Effect of postconditioning on infarction size, adverse left ventricular remodeling, and improvement in left ventricular systolic function in patients with first anterior STsegment elevation myocardial infarction. Pol Arch Med Wewn 2013; 123: 268-76
  5. Cheitlin MD, Armstrong WF, Aurigemma GP, Beller GA, Bierman FZ, Davis JL, et al. ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). Circulation 2003; 108: 1146-62. [CrossRef] 7. Nechvatal L, Hlinomaz O, Groch L, Hornacek I, Sitar J, Orban M, et al. Serial echocardiographic assessment of the left ventricular function after direct PCI. Kardiol Pol 2003; 59: 397-401
  6. Wickline SA, Verdonk ED, Wong AK, Shepard RK, Miller JG. Structural remodeling of human myocardial tissue after infarction. Quantification with ultrasonic backscatter. Circulation 1992; 85: 259-68. [CrossRef] 9. Benavides-Vallve C, Corbacho D, Iglesias-Garcia O, Pelacho B, Albiasu E, Castano S, et al. New strategies for echocardiographic evaluation of left ventricular function in a mouse model of longterm myocardial infarction. PLoS One 2012; 7: e41691. [CrossRef] 10. Uslu H, Çakmak N, Erkan ME, Hacımahmutoğlu S, Yılmaz S, Özkan S, et al. Left ventricular remodeling assessment in patients with anterior acute myocardial infarction treated with successful primary percutaneous coronary intervention: an observational study. Anatol J Cardiol 2013; 13: 675-81. [CrossRef] 11. Masci PG, Ganame J, Francone M, Desmet W, Lorenzoni V, Iacucci I, et al. Relationship between l