Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2016 / Cilt: 50 - Sayı: 4

Serebral kalsifikasyon tanısı alan hastalar çölyak hastalığı açısından araştırılmalı mı?

Should Children Diagnosed with Cerebral Calcification be Screened for Celiac Disease?

Pages
309–314
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It suggested that occurrence of calcification in choroid plexus and/or pineal gland might be related to celiac disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to examine the prevalence and relationship of celiac disease (CD) in children with cerebral calcifications (CC).
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Key Findings & Data:Results: A total of 129 children with CC (75 boys, 54 girls; age: 6 months to 16 years) were evaluated.
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Conclusion & Impact:It suggested that occurrence of calcification in choroid plexus and/or pineal gland might be related to celiac disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to examine the prevalence and relationship of celiac disease (CD) in children with cerebral calcifications (CC). Material and Methods: Children with cerebral calcifications were screened for celiac disease using the anti-tissue transglutaminase IgA antibody. Results: A total of 129 children with CC (75 boys, 54 girls; age: 6 months to 16 years) were evaluated. Control group consisted of 223 healthy children. The prevalence of CD was significantly higher in patients with CC than control subjects (p=0.01). In three patients pathological examination of duodenal biopsy resulted as total villous atrophy. All three patients had both iron deficiency anemia and short stature problem. Although, no calcification in occipital lobe was detected in computed tomography of these three patients, there were nonspecific calcifications in choroid plexus and pineal gland localizations. Conclusion: According to results from our study, prevalence of celiac disease being low in patients with intracerebral calcifications suggested that there is not a strong correlation between development of calcification and celiac disease. It suggested that occurrence of calcification in choroid plexus and/or pineal gland might be related to celiac disease.

Özet

Amaç: Bu çalışmada Çölyak hastalığı ve serebral kalsifikasyon arasındaki ilişki ve prevalansı saptamayı amaçladık.Gereç ve Yöntemler: Serebral kalsifikasyonu olan çocuklar çölyak hastalığı yönünden anti-doku transglutaminaz IgA kullanılarak tarandı.Bulgular: Toplamda 129 serebral kalsifikasyonu olan hasta (6 ay-16 yaş arası 75 erkek ve 54 kız) tetkik edildi. Kontrol grubu 223 sağlıklı çocuktan oluşmaktaydı. Çölyak hastalığı olan hastalarda serebral kalsifikasyon anlamlı olarak yüksek bulundu (p=0.01). Üç hastanın duodenal biyopsisinde total villus atrofisi saptandı. Bu hastalarda demir eksikliği anemisi ve boy kısalığı mevcuttu. Bu hastalarda oksipital lobda kalsifikasyon saptanmadı. Koroid pleksus ve pineal glandda nonspesifik kalsifikasyonlar saptandı.Sonuç: Çalışmamızın sonuçlarına göre, intrakranial kalsifikasyonun çölyak hastalarında az miktarda olması intrakranial kalsifikasyon ve çölyak hastalığı arasında güçlü bir birliktelik olmadığını gösterdi. Pineal gland ve koroid pleksusta kalsifikasyonun olması Çölyak hastalığı ile ilişkili olabilir.

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Cite This Article

IŞIKAY, S., KİRİK, S., IŞIKAY, N., HIZLI, Ş., GÜNGÖR, O., KİRİK, Y. (2016). Serebral kalsifikasyon tanısı alan hastalar çölyak hastalığı açısından araştırılmalı mı?. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 50 - Sayı: 4, 309–314. https://ajindex.com/articles/364124

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