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Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2019 / Cilt: 53 - Sayı: 2

The Effect of Single High-Dose Preoperative Intravenous Tranexamic Acid Administration to Reduce Blood Loss in Patients with Primary Total Knee Replacement

Mehmet Ali TALMAÇ
Mehmet Akif GÖRGEL
Sema ERTAN BİRSEL
Mehmet Mesut SÖNMEZ
Hacı Mustafa ÖZDEMİR
Pages
137–142
DOI
—
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Postoperatively, themean hemoglobin and hematocrit levels of T − group were statistically significantly lower than T + group.Conclusion: A single 20 mg/kg iv TA administration before TKR reduces bleeding during surgery and within 24 h postoperatively.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aimed to analyze the efficacy of single-dose tranexamic acid (TA) 20 mg/kg preoperatively to reduce bloodloss in patients undergoing total knee replacement (TKR).Methods: A total of 387 patients (82 males, 305 females) undergoing TKR between January 2014 and December 2018 were includedin the study.
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Key Findings & Data:The T + group was administrated intravenous (iv) TA 20 mg/kg 20 min before the skin incision.
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Conclusion & Impact:Postoperatively, themean hemoglobin and hematocrit levels of T − group were statistically significantly lower than T + group.Conclusion: A single 20 mg/kg iv TA administration before TKR reduces bleeding during surgery and within 24 h postoperatively.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Özet

Objectives: This study aimed to analyze the efficacy of single-dose tranexamic acid (TA) 20 mg/kg preoperatively to reduce bloodloss in patients undergoing total knee replacement (TKR).Methods: A total of 387 patients (82 males, 305 females) undergoing TKR between January 2014 and December 2018 were includedin the study. The T + group was administrated intravenous (iv) TA 20 mg/kg 20 min before the skin incision. We determined perioperative blood loss, the amount of drainage postoperative 24 h, the amount of drainage after postoperative 24–48 h, total volume ofdrains, total volume of blood loss, postoperative hemoglobin and hematocrit levels, and amount of total blood transfusion.Results: In terms of demographic data, no statistically significant difference was observed between the groups. Perioperativeblood loss and total volume of blood loss was found statistically higher in T − group compared to T + group. Postoperatively, themean hemoglobin and hematocrit levels of T − group were statistically significantly lower than T + group.Conclusion: A single 20 mg/kg iv TA administration before TKR reduces bleeding during surgery and within 24 h postoperatively.

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Cite This Article

TALMAÇ, M. A., GÖRGEL, M. A., BİRSEL, S. E., SÖNMEZ, M. M., ÖZDEMİR, H. M. (2019). The Effect of Single High-Dose Preoperative Intravenous Tranexamic Acid Administration to Reduce Blood Loss in Patients with Primary Total Knee Replacement. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 53 - Sayı: 2, 137–142. https://ajindex.com/articles/364011

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