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Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2004 / Cilt: 38 - Sayı: 1

Retrospective evaluation of the patients with tuberculous meningitis for early diagnosis

Tüberküloz menenjitli hastaların erken tanı için retrospektif taranması

Tülay OLGUN
Gül ÖZÇELİK
Esra Deniz PAPATYA
Deniz ÇAKIR
MAHMUT EKİCİ
ATALAY DEMİREL
Pages
24–27
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The diagnoisis of CNS tuberculosis should be considered in all children with neurologic signs and symptoms of, and risk factors for tuberculosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Tuberculous meningitis is associated with high morbidity and mortality if there is a delay in diagnosis. 32 children clinically suspected to have tuberculous meningitis were included in this study.
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Key Findings & Data:History, examination, CSF findings and CT scan were recorded 21 patients were younger than five years, a contact source was identified in 13 patients (%40).
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Conclusion & Impact:The diagnoisis of CNS tuberculosis should be considered in all children with neurologic signs and symptoms of, and risk factors for tuberculosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tüberküloz · meningeal · Geriyedönük çalışma

Abstract

Tuberculous meningitis is associated with high morbidity and mortality if there is a delay in diagnosis. 32 children clinically suspected to have tuberculous meningitis were included in this study. History, examination, CSF findings and CT scan were recorded 21 patients were younger than five years, a contact source was identified in 13 patients (%40). Previous BCG had only been given to 9 (%28). The Mantoux reaction was positive in 9 (%28), abnormalities of the chest X- ray were found 6 (%I8). %57 percent of these patients presented with stage II and 31 percent of the patients presented with stage III. Mycobacterium tuberculosis was either culture or identified by acid-fast stain from CSF and early morning gastric aspirates in six patients. Cranial tomography scans of the patients showed hydrocephalus in fourteen patients (%43) and basillar enhancement in four patients, Tuberculoma in five patients. The diagnoisis of CNS tuberculosis should be considered in all children with neurologic signs and symptoms of, and risk factors for tuberculosis.

Özet

Tüberküloz menenjit erken tanı kurtulamadığında, yüksek oranda mortalite ve morbiditeye sebep olmaktadır. Bu amaçla klinik olarak tüberküloz menenjit olduğu düşünülen 32 hasta retrospektif olarak incelendi. Hikaye, fizik muayene, BOS ve kraniyal tomografi bulguları kaydedildi. 21 hasla beş yaş alımdaydı, tüberkülozlu olduğu bilinen bir vakayla temas öyküsü 13 (%40) hastada, Mantoux deri testi pozitifliği 9 hastada (%28) saplandı. BCG aşısı 9 (%2H) hastaya yapılmıştı. 6 hastada (%/<S'J göğüs radyogramında anormallik saptandı. Hastaların %57'si ilk başvuruda Evre 11' de, %31'i Evre III deydi. 3 hastada BOS ya da açlık mide suyunda Mycobacterium tuberculosis küllünle üretildi, 3 hastada asido rezislan boyamayla basil saptandı. Kraniyal tomografide 14 hastada (%43) hidrosefali, 4'ünde (%12) bazitler tutulum, 5'inde (%I5) tüberküloma tespit edildi. Nörolojik semptom ve bulguları olan ve tüberküloz için risk faktörü taşıyan tüm çocuklarda ilk akla gelen MSS tüberkülozu olmalıdır.

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Cite This Article

OLGUN, T., ÖZÇELİK, G., PAPATYA, E. D., ÇAKIR, D., EKİCİ, M., DEMİREL, A. (2004). Retrospective evaluation of the patients with tuberculous meningitis for early diagnosis. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 38 - Sayı: 1, 24–27. https://ajindex.com/articles/363943

References (13)

  1. Newton R.W., Archives of Disease in childhood 1994; 70:364-366
  2. Speert D.P, Tuberculosis. In: Krugman S., ed. Infectious Diseases of Children Ninth Edition, Mosby Company, USA Missouri 1992, 551-572 3. Doerr C.A., Starke J.R., Ong l.t.: Clinical and public health aspects of tuberculous menengitis in. The J of Ped Volume 127, no I, July 1995, 27-33
  3. Öneş Ü., Güler N.,Tüberküloz Neyzi O., ed. Pediatri 2. Baskı, Nobel Tıp Kitabevleri,Türkiye İstanbul 1993 10:4 658-673
  4. American Academy of Pediatrics Tuberculosis, in: Pic-kening L.K., ed. 2000 Red Book: Report of the Com-mitee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000: 593-613
  5. Fine P.E.M., Bacille Calmette-Guerin Vaccines: A Rough Guide, Clinical Infectious Diseases 1995:20:11-14
  6. Colditz G.A., Berkey C.S., Mosteller F., et al: The Efficacy of BCG Vaccination of Newborns and Infants in the Prevention of Tuberculosis: Meta-Analysis of the Published Literature. Pediatrics Vol:96 No: 1 July 1995; 29-35
  7. Farinha N.J., Razali K.A., Holzel H. Et al: J Infectious 2000 Jul; 41 (1): 61-8 Tuberculosis of the central nervous system in children: A 20-year survey
  8. Rich A.R., Mc Cordock H., Pathogenesis of tuberculosis. Book 2nd. Springfield, Illinois: Charles C Thomas 1951
  9. Crofton J., Home N„ Miller F., Tüberkülin Testi, Klinik tüberküloz 2. Baskı, Yüce Yayım, Türkiye İstanbul (çeviri) 2002; 200-205
  10. Paganini H., Gonzalez F., Santander C. Et al: Tuberculous menengitis in children: clinical features and outcome in 40 cases, Scand J Infect Dis 2000; 32 (l):41-5
  11. Starke J.R., Taylor-Watts K.T. Tuberculous menengitis in children J Pediatrics 1960; 57: 807-23
  12. Tan E.K., Chee M.W., Chan L.L. et al: Culture positive tuberculous menengitis: clinical indicators poor prognosis. Neurol neurosurg 1999 Sep; 101(3): 157-60
  13. Hoşoğlu S., Geyik M.F., Balık I. et al: Predictors of outcome in patients with tuberculous meningitis. Int J Tuberc Lung Dis 2002 Jan; 6 (1): 64-70.