Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2015 / Cilt: 49 - Sayı: 2

Comparison of body mass index and lipid levels between obese and normal weighted hypothyroid patients

Obez ve normal kilolu hipotiroidi hastalarının beden kitle indeksi ve lipid değerlerinin karşılaştırılması

Pages
131–134
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

During therapies of hypothyroidic patients, hyperlipidemia have to be investigated and also when beginning of an antihyperlipidemic treatment thyroid hormones have to be evaluated.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In hypothyroidic patients obesity and hyperlipidemia is more often.
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Key Findings & Data:Material and Method: Files of 37 hypothyroidic patients followed up by lipid polyclinic of Haseki Hospital between 2003-2006 years are evaluated retrospectively.
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Conclusion & Impact:During therapies of hypothyroidic patients, hyperlipidemia have to be investigated and also when beginning of an antihyperlipidemic treatment thyroid hormones have to be evaluated.
🔬Design:Research Article
📍Scope:2003-2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In hypothyroidic patients obesity and hyperlipidemia is more often. In this study hypothroid patients followed by Haseki Hospital lipid polyclinic evaluated and hyperlipidemia-obesity relation investigated. Material and Method: Files of 37 hypothyroidic patients followed up by lipid polyclinic of Haseki Hospital between 2003-2006 years are evaluated retrospectively. Patients divided into two groups as obese (case) and nonobese (control) according to their body mass indexes (BMI) ( &#8805; 30=obese) at the time they refer. Age, sex, BMI, glucose, TSH, total-cholesterol, LDL, HDL, triglyceride values of patients evaluated. Results: 19 were obese (case group), 18 were nonobese (control group) from 37 patients with hypothyroidism admitted to our study. Case group had 1 male, 18 female, control group had 6 male, 12 female patients. In case group, HDL was lower (p<0.01) and glucose was higher (p<0.01) than control group. Triglycerides of case group was higher than control group, but this difference wasn’t significant (p=0.31). There wasn’t difference between groups in the levels of total and LDL-cholesterol. Conclusion: We evaluated hypothroidic patients by dividing them to obese and nonobese groups according to their BMI. Total and LDL cholesterol levels of groups showed no significant difference. Trigliceryde and glucose levels of obese group was high and HDL-cholesterol was low. During therapies of hypothyroidic patients, hyperlipidemia have to be investigated and also when beginning of an antihyperlipidemic treatment thyroid hormones have to be evaluated.

Özet

Amaç: Hipotiroidi hastalarında obezite ve beraberinde hiperlipidemi görülmektedir. Bu çalışmada Haseki Eğt. Arş. Hastanesi lipit polikliniğinden takip edilen hipotirodi hastalarının laboratuar verileri değerlendirilerek hipotiroidik hastalarda obezite ile lipit değerleri ilişkisi araştırıldı. Gereç ve Yöntem: Haseki Eğt. Arş. Hastanesi lipit polikliniğinde 2003-2006 yıllarında takip edilen 37 hipotiroidi hastasının dosyası retrospektif olarak incelendi ve hastalar, başvuru sırasındaki vücut kitle indeksleri (VKİ) ( ≥30=obez) dikkate alınarak obez (vaka) ve nonobez (kontrol) olarak 2 gruba ayrıldı. Çalışmada hastaların yaş, cinsiyet, VKİ, glukoz, TSH, total kolesterol, LDL, HDL, trigliserit değerleri dikkate alındı. Bulgular: Çalışmaya alınan 37 hipotiroidi hastasından 19u obez (vaka grubu), 18i nonobez (kontrol grubu) olarak değerlendirildi. Vaka grubu 1 erkek, 18 kadın, kontrol grubu ise 6 erkek, 12 kadın hasta - dan oluştu. Vaka grubunun HDL değerleri anlamlı olarak düşük saptandı (p<0.01). Glukoz değerleri de anlamlı olarak yüksek saptandı (p<0.01). Vaka grubunun trigliserit değerleri kontrol grubuna kıyasla yüksek olmakla birlikte istatistiksel anlamlı bir fark yoktu (p=0.31). Gruplar arasında LDL ve total kolesterol açısından anlamlı bir farklılık saptanmadı. Sonuç: Hipotiroidili hastalarda obezite sık görülmekte olup, bu grupta hiperlipidemi ve glukoz into- leransına da daha sık rastlanmaktadır. Yaptığımız çalışmada VKİlerine göre obez ve nonobez olarak ikiye ayrılan hipotiroidi hastalarının total kolesterol ve LDL değerleri arasında anlamlı bir fark saptan - madı. Obez grubun trigliserit ve glukoz değerleri yüksek, HDL değerleri düşük saptandı. Hipotiroidi hastalarının tedavisi sırasında hiperlipidemi gözden kaçırılmamalı aynı zamanda tek başına hiperlipi - demisi olan hastalarda tedavi öncesi tiroid hormonları görülmelidir.

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Cite This Article

ÖZŞENEL, E. B., GÜRLER, M. Y., KARATEMİZ, G., BORLU, F., KALKAN, K., GÜVEN, E., DEMİR, N. Ö., COŞGUN, S., SAVAŞ, Ö., ŞAR, F. (2015). Comparison of body mass index and lipid levels between obese and normal weighted hypothyroid patients. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 49 - Sayı: 2, 131–134. https://ajindex.com/articles/363832

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References (15)

  1. Ersin A, Faruk A, Betül A, Ferihan A, Göksun A, Harika B ve ark. Türkiye Endokrinoloji ve Metabolizma Derneği, Tiroid hastalıkları tanı, tedavi ve izlem kılavuzu. 4. baskı 2014; s: 16-8
  2. Papadakis M, Mcphee SJ, Rabow MW. Current Medical Diagnosis and Treatment, 53rd edition. McGraw-HillCurrent Series 2014; 1065-9
  3. Pucci E, Chiovato L, Pinchera A. Thyroid and lipid metabolism. Int. J. Obesity Related Metabolic Disorders 2000; 24: 109-12
  4. Michalopoulou G, Alevizaki M, Piperingos G, Mitsibounas D, Mantzos E, Adamopoulos P, et al. High serum cholesterol levels in persons with high-normal TSH levels. European J. Endocrinology 1998; 138: 141-5
  5. Sridevi A, Vivekanand B, Giridhar G, Mythili A, Subrahmanyan KA. Insulin resistance and lipid alterations in subclinical hypothyroidism. Indian J. Endocrinology and Metabolism 2012; 16: 345-6
  6. Carantoni M, Vigna GB, Stucci N, Zanca R, Fellin R. Low levels of HDL cholesterol in hypothyroid patients with cardiovascular diseases. Minerva Endocrinology 1997; 22: 91-7
  7. O’Brien T, Dinen SF, O’Brien PC, Palumbo PJ. Hyperlipidemia in patients with primary and secondary hypothyroidism. Mayo Clin. Proc 1993; 68: 860-6
  8. Pearce EN. Hypothyroidism and dyslipidemia: modern concepts and approches. Current Cardiology Reports 2004; 6: 4516
  9. Lee YK, Kim JE, Oh HJ, Park KS, Kim SK, Park SW, et al. Serum TSH levels in healthy Koreans and the association of TSH with serum lipid concentration and metabolic syndrome. Korean J. Internal Medicine 2011; 26: 432-9
  10. Bahrami E, Mirmoghtadaee P, Ardalan G, Zarkesh-Esfahani H, Tajaddini MH, Haghjooy-Javanmard S. Insulin and leptin levels in overweight and normal-weight Iranian adolescents: The CASPIAN-III study. J Res Med Sci 2014; 19: 387-90
  11. Gierach M, Gierach J, Junik R. İnsülin resistance and tyroid disorders. Endokrynol Pol 2014; 65: 70-6
  12. Valkoska Nakova V, Krstevska B, Bosevski M, Dimitrovski CH, Serafimoski V. Dyslipidemia and hypertension in patients with subclinical hypothyroidism. Prilozi 2009; 30: 93-102
  13. Yıldırımkaya M, Özata M, Yılmaz K, Kılınç C, Gündoğan MA, Kutluay T. Lipoprotein (a) concentration in subclinical hypothyroidism before and after levothyroxine therapy. Endocrinology J 1996; 43: 731-6
  14. Kung AW, Pang RW, Janus ED. Elevated serum lipoprotein (a) in subclinical hypothyroidism. Clinical Endocrinology (Oxford) 1995; 43: 445-9
  15. Miura S, Litaka M, Yoshimura H, Kitahama S, Fukasawa N, Kawakami Y, et al. Disturbed lipid metabolism