AI Summary & Key Takeaways
AI InsightConclusion: The laryngeal cancer patients with positive lymph node, with transglottic tumour and with poorly/moderately differentiated tumour should be monitored carefully and followed up closely for possible pulmonary metastasis.
📌 3 Key Takeaways
Abstract
Objective: To identify the factors associated with pulmonary metastasis, such as lymph node positivity, tumour location and histological differentiation in patients with laryngeal squamous cell carcinoma (scc).Material and Methods: This study is designed as retrospective cohort study. Data from 263 patients diagnosed with laryngeal scc were reviewed retrospectively. Pulmonary metastasis was observed in 39 of these patients. Results: The transglottic tumors had the highest pulmonary metastasis rate (%50). The pulmonary metastasis rate was significantly lower in patients with glottic tumors than those with tumors in other regions (p= 0.003) The pulmonary metastasis rate was higher in lymph node-positive patients than in lymph node-negative patients. Pulmonary metastasis rate was significantly higher among patients with N2-N3 stage lymph nodes compared to those with N1 stage lymph nodes. Pulmonary metastasis rate is also increased significantly among patients with histologically poorly differentiated tumors (p= 0.001). Conclusion: The laryngeal cancer patients with positive lymph node, with transglottic tumour and with poorly/moderately differentiated tumour should be monitored carefully and followed up closely for possible pulmonary metastasis.
Özet
Amaç: Çalışmanın amacı, larenks karsinomlu hastalarda boyun lenf nodu pozitifliği, tümör yerleşimi ve histolojik diferansiasyon gibi faktörlerin pulmoner metastazdaki rollerini belirlemektir.Gereç ve Yöntemler: Larenks karsinomu tanısı alan 263 hastanın verileri retrospektif olarak incelendi. Otuzdokuz hastada pulmoner metastaz saptandı.Bulgular: En yüksek pulmoner metastaz oranı, transglottik tümörlerde saptandı (%50). Glotik tümörlerde diğer bölgelere kıyasla pulmoner metastaz oranı çok düşüktü (p= 0.003). Boyun evresi N2-N3 olan hastalarda pulmoner metastaz oranı, N1 olan hastalardan anlamlı olarak daha yüksekti. Az diferansiye tümörlerde pulmoner metastaz oranı anlamlı olarak artmıştı (p= 0.001).Sonuç: Boyun lenf nodu pozitif olan, tümörü transglottik yerleşimli olup orta veya az diferansiye olan larenks tümörü hastaları pulmoner metastaz açısından dikkatli takip edilmelidir.