SavedAdd your journal

Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2018 / Cilt: 52 - Sayı: 2

Effect of 900-MHz Electromagnetic Field on the Cerebellum: A Histopathological Investigation

TOLGA MERCANTEPE
LEVENT TÜMKAYA
Mehmet Fatih GÖKÇEK
ZEHRA TOPAL SUZAN
Erva ESMER
Pages
129–134
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: A 900-MHz EMF causes deleterious effects on the cerebellum by giving rise to apoptosis accompanied by caspase-3 expression in the Purkinje and granular cells in particular.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The currently widely used technological devices give rise to electromagnetic fields (EMFs) at various frequencies.
📊
Key Findings & Data:Our study involved a histopathological evaluation of the effects of communication systems’ standard 900-MHz EMF on the cerebellum.
💡
Conclusion & Impact:Conclusion: A 900-MHz EMF causes deleterious effects on the cerebellum by giving rise to apoptosis accompanied by caspase-3 expression in the Purkinje and granular cells in particular.
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: The currently widely used technological devices give rise to electromagnetic fields (EMFs) at various frequencies. Recent studies have reported that EMFs damage the central nervous system. The cerebellum is of considerable importance to human life due to its involvement in motor control, language, and cognitive-sensory functions. Damage occurring in the histological layers of the cerebellar cortex causes various neurological and psychiatric diseases, such as paralysis, tumor, autism, and schizophrenia. Our study involved a histopathological evaluation of the effects of communication systems’ standard 900-MHz EMF on the cerebellum. Methods: Sprague–Dawley rats were assigned into two groups containing six animals each: control and EMF. The EMF group was exposed to a 24-h 900-MHz radiofrequency EMF over 20 days with a digital modulation signal generator installed in the middle of their cage. Ten days after EMF application, the rats were sacrificed by cervical dislocation under anesthesia induced with 50 mg/kg ketamine hydrochloride and 10 mg/kg intraperitoneal xylazine HC1. Results: Intense caspase-3 expression was seen in the Purkinje cells and granular cells exposed to a 900-MHz frequency EMF (p 0.05). Conclusion: A 900-MHz EMF causes deleterious effects on the cerebellum by giving rise to apoptosis accompanied by caspase-3 expression in the Purkinje and granular cells in particular.

🔖

Cite This Article

MERCANTEPE, T., TÜMKAYA, L., GÖKÇEK, M. F., SUZAN, Z. T., ESMER, E. (2018). Effect of 900-MHz Electromagnetic Field on the Cerebellum: A Histopathological Investigation. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 52 - Sayı: 2, 129–134. https://ajindex.com/articles/363730

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Topal Z, Hanci H, Mercantepe T, Erol HS, Keleş ON, Kaya H, et al. The effects of prenatal long-duration exposure to 900-MHz electromagnetic field on the 21-day-old newborn male rat liver. Turkish J Med Sci 2015;45:291–7.
  2. Sonmez OF, Odaci E, Bas O, Kaplan S. Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field. Brain Res 2010;1356:95–101.
  3. Coşkun G, Özgür H. Molecular Mechanism of Apoptosis and Necrosis [Article in Turkish]. Arşiv Kaynak Tarama Derg 2014;20:145–58.
  4. Bedir R, Tumkaya L, Şehitoğlu İ, Kalkan Y, Yilmaz A, Şahin OZ, et al. The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development. Ren Fail 2015;37:305–9.
  5. Grisoli M, Piperno A, Chiapparini L, Mariani R, Savoiardo M. MR imaging of cerebral cortical involvement in aceruloplasminemia. AJNR Am J Neuroradiol 2005;26:657–61.
  6. Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci 2002;22:6578–86. Schmahmann JD. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 2004;16:367–78. Steinlin M. Cerebellar disorders in childhood: Cognitive problems. Cerebellum 2008;7:607–10.
  7. Schmahmann JD, Weilburg JB, Sherman JC. The neuropsychiatry of the cerebellum - insights from the clinic. Cerebellum 2007;6:254–67.
  8. Marques JP, Gruetter R, van der Zwaag W. In vivo structural imaging of the cerebellum, the contribution of ultra-high fields. Cerebellum 2012;11:384–91.
  9. Frei MR, Berger RE, Dusch SJ, Guel V, Jauchem JR, Merritt JH, et al. Chronic exposure of cancer-prone mice to low-level 2450 MHz radiofrequency radiation. Bioelectromagnetics 1998;19:20–31.
  10. Akdag MZ, Dasdag S, Ulukaya E, Uzunlar AK, Kurt MA, Taşkin A. Effects of extremely low-frequency magnetic field on caspase activities and oxidative stress values in rat brain. Biol Trace Elem Res 2010;138:238–49.
  11. Pace V, Bellizzi D, Giordano F, Panno ML, De Benedictis G. Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis. Cell Stress Chaperones 2010;15:13–23.
  12. Snigdha S, Smith ED, Prieto GA, Cotman CW. Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull 2012;28:14–24.
  13. Folch J, Alvira D, López-querol M, Tajes M, Sureda FX, Forsby A, et al. Evaluation of transcriptional activity of caspase-3 gene as