Breast cancer under age 35

Objective & Hypothesis:Objective: Breast cancer is quite rare in the 35 and under age group and it is believed that it is more agressive when it occurs in this age group.

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Key Findings & Data:The purpose of our study is retrospectively examine the tumor characteristics, the progression of the disease and survival rates of 86 patients which fall into this age group.

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Conclusion & Impact:In the above mentioned follow-up period, Disease Free Survival (DFS) rate was 68,6% and Overall Survival (OS) rate was 87%.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Sağkalım oranı · Antineoplastik protokoller · Meme neoplazmları

Abstract

Objective: Breast cancer is quite rare in the 35 and under age group and it is believed that it is more agressive when it occurs in this age group. The purpose of our study is retrospectively examine the tumor characteristics, the progression of the disease and survival rates of 86 patients which fall into this age group. Study Design: 86 patients treated in between 1989-1998 in our department and followed up for at least 6 months were examined in this study. Results: The median age was 30 (the youngest being 23; oldest 35) invasive ductal carcinoma was the most frequently observed histological type (87,2 %). Modified Radical Mastectomy was the most applied surgical procedure (74,4 %). 63,9 % of the patients had positive Axillar lenf nodes. According to the TNM was classification, the distruhition of stages among patients was as follows: Stage/: 4 (4,7%) patients, Slagell: 49 (56,9 %) patients, Stage 111: 27 (31,4%) patients, Stage IV: 6 (7%) patients. Adjuvant Radiotherapy was applied to 76,7 % of the patients. FEC had been the most utilized chemotherapy regime (67,7 %). 53,5% of the patients were administred hormonal therapy. With a follow-up overage of 37 months(min 6-max 1/4), in 27 (31,4%) patients, local and/or distant metastasis occured and 11 (12,8 %) patients died. In the above mentioned follow-up period, Disease Free Survival (DFS) rate was 68,6% and Overall Survival (OS) rate was 87%. Conclusion: In the median 37 (6-114) months follow-up 86 breast cancer patients 35 and under age group DFS was %68,6 and OS was %87. As a conclusion, it can be asserted that for the mentioned age group, breast cancer shows for more agressive tumor characteristics. However, due to the fad that the average follow-up period was short,this conclusion can not be accepted as fact,as yet.

Özet

Amaç: 35 ve altı yaş grubunda meme kanserleri oldukça nadirdir ve daha agresif seyirli oldukları düşünülmektedir. Bu çalışmanın amacı, bu yaş grubunda yer alan 86 hastada, tümör özellikleri, hastalık seyri ve sağkalım oranlarının retrospektif olarak irdelenmesidir. Gereç ve Yöntem: Tanımlayıcı tipteki bu araştırmada, Şişli Etfal Eğitim ve Araştırma Hastanesi Radyasyon Onkolojisi Kliniğine 1989-1998 yılları arasında başvurup tedavi edilen ve en az 6 ay takipte kalan 86 hasta retrospektif olarak incelenmiştir. Bulgular: Hastaların ortalama yaşı 30 (23-35) olup, en sık rastlanan tümör hislopatolojisi %,87.2 ile invaziv duktal karsinomadır. 15 (%I7,4) hasta Oral Kontraseptif (OK) kullanmıştır. Modifiye Radikal Mastektomi (MRM) %74,4 ile en sık uygulanan cerrahi yöntem olmuştur. Hastaların %63,9'unda Aksiller lenf nod tutulumu mevcuttur. TNM sınıflamasına göre hasta dağılımı şöyledir: Evre I, 4 (%4,7) hasta, Evre II, 49 (%56,9) hasta Evre 111, 27 (%3I,4) hasta ve Evre IV, 6 (%7) hasta. Hastaların % 76,7'sine Adjuvant Radyoterapi uygulanmışın: En sık kullanılan Kemoterapi rejimi %67,4 ile FEC olmuştur. Hastaların %53,5'i hormonal tedavi almıştır. Ortalama 37 (6-114) aylık izlemde 27 (%31,4) hastada yerel ve/veya uzak yinelemeler olmuştur. II (%I2,H) hasta exitus olmuştur. Bu izem süresinde Hastalıksız Sağkalım % 68,6 ve Genel Sağkalım % 87 olarak kaydedilmiştir. Sonuç: 35 yaş ve altı meme kanserli 86 hastada medyan 37 (6-114) aylık takiple Haslalıksız Sağkalım %68,6 ve Genel Sağkalım % 87 dır. Bu bulgulara göre 35 yaş ve altı meme kanserlerinin daha agresif özellikler gösterdiği söylenebilir. Ancak izlenı süresinin kısalığı nedeniyle kesin bir kanıya varmak zordur.

Keywords

Sağkalım oranı Antineoplastik protokoller Meme neoplazmları Erişkin Geriyedönük çalışma Neoplazm evrelendirilmesi Survival Rate Antineoplastic Protocols Breast Neoplasms Adult Retrospective Studies Neoplasm Staging

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Cite This Article

AKSAKAL, Ö., KIZILKAYA, H. O., UYANOĞLU, A., AKYÜZ, F., DOĞAN, A., İNCEKARA, O., TANIK, C. (2005). Breast cancer under age 35. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 39 - Sayı: 4, 31–35. https://ajindex.com/articles/363640

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