Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2003 / Cilt: 37 - Sayı: 2

Neutrophil hypersegmentation in iron deficiency anemia

Demir eksikliği anemisinde nötrofil hipersegmentasyonu

Pages
15–20
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These results show that neutrophil hypersegmentation may also be seen in patients with iron deficiency anemia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Neutrophil hypersegmentation is an expected peripheral blood smear finding in megalohlastic anemias.
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Key Findings & Data:In this study we searched presence of neutrophil hypersegmentation in patients with iron deficiency anemia but have normal vitamin B12 andfolic acid levels.
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Conclusion & Impact:Conclusion: These results show that neutrophil hypersegmentation may also be seen in patients with iron deficiency anemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nötrofiller · Folik asit · Vitamin B 12

Abstract

Objective: Neutrophil hypersegmentation is an expected peripheral blood smear finding in megalohlastic anemias. Clinical reports suggest that neutrophil hypersegmentation may also occur in patients with iron deficiency anemia. In this study we searched presence of neutrophil hypersegmentation in patients with iron deficiency anemia but have normal vitamin B12 andfolic acid levels. Study Design: The subjects (n:123) were divided into two groups : the patients with iron deficiency anemia constituted Group I (n:102), and the healthy controls Group II (n:2I). The average ages and sexuality of both groups were comparative. Results: Hypersegmentation was found in 30.4 % of Group I and 9.5% of Group U (p<0.05). Conclusion: These results show that neutrophil hypersegmentation may also be seen in patients with iron deficiency anemia.

Özet

Amaç: Nötrofil hipersegmentasyonu, megalohlastik anemilerde beklenen bir periferik yayma bulgusudur. Yapılan araştırmalar demir eksikliği anemisi leshit edilen hastalarda da nötrofil hipersegmentasyonu olabileceğini göstermiştir. Biz de bu çalışmamızda demir eksikliği anemisi olan, ancak B12 vitamini ve folik asit düzeyleri normal bulunan hastalarda nötrofil hipersegmentasyonu sıklığını araştırdık. Gereç ve Yöntemler: Çalışmaya katılan vakalar (n:l23) iki gruba ayrıldı: Grup 1 demir eksikliği anemili 102 hastayı, kontrol grubu olan Grup II ise sağlıklı 21 hastayı kapsıyordu. Her iki grubun ortalama yaşları ve cinsiyet dağılımları benzerdi. Bulgular: Hipersegmentasyon Grup I'de %30.4, Grup II'de ise %9.5 sıklığında bulundu. Gruplar arasında hipersegmentayson varlığı yönünden istatistiksel olarak anlamlı bir fark vardı (p < 0,05). Sonuç: Bu bulgular bize nötrofil hipersegmantasyonunun izole demir eksikliği anemisi olan hastalarda da görülebileceğini göstermektedir.

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Cite This Article

DÜZGÜN, S., YILDIRMAK, Y., ÇETİNKAYA, F., KUTLUK, G., UYSALOL, M., AKIŞIK, M., YILDIRIM, R. (2003). Neutrophil hypersegmentation in iron deficiency anemia. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 37 - Sayı: 2, 15–20. https://ajindex.com/articles/363566

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References (16)

  1. Lönnerdal B,Dewey KG. Epidemiology of Iron Deficiency in Infants:ind Children.Annales of Nestle 1995;53 (1): 11-17
  2. Reid CD, Prouse PJ, Babtista LC, Gumpel JM, Chanarin I. The Mechanism of Anemia in Rheumatoid Arthritis. Br J Haematobgy 1984; 58 (4): 607-615
  3. Soysal T, Soycun LY. Anemiler. Î.Ü. Cerrahpaşa Tıp Fakültesi, Sürekli Tıp Eğitimi Etkinlikleri Sempozyum Dizisi No:25 2001; 25-40
  4. Hastka J, Lasserre JJ, Schwarzbcck A, et al. Laboratory tests of iron status: Correlation or common sense? Clin Chem. 199G; 718-724
  5. Morgan DL, Peck SD. The Use of red cell distribution width in thu detection of iron deficiency in chronic hemo-dialysis patients. Am J Clin Pathol. I988;89: 513-515
  6. Jaime JC, Cuzarcz r, Marcs MA, et al. Iron stores in remunerated blond donors as evaluated by pkismu I'errilin levels. Transfusion. 1988; 62-65
  7. Rotlgers, M.S., Chang, C.C. & Kass, L. Elliptocytes and tailed poikilocytes corralete with severity of iron deficiency anemia. American Journal of Clinical Pathology. 1999; 111:672-675
  8. Fairbanks VF, Beutter E. Iron deficiency. In: Williams WJ, Belitler E, Erslev AJ, et al, eds. Hcmatology. New York, NY: McGraw Hill; 1990: 482-505
  9. Hangoc G, Yin T, Cooper S, Schendal P, Yang Y-C, Brox-meyer HE: In vivo effects of recombinanl 1L-1I on mye-lopoiesis in mice. Blood 1993; 81: 965-972
  10. Ishibashi T, Kimuru H, Uchida T, Kariyone S, Friesc P, Burstein SA: Human IL-6 is a direct promotor of maturation of megakaryocytes in vitro. Proc Natl Acad Sci USA 1989;86: 5953-5957
  11. Akan H, Güven N, Aydoğdu I, Arat M, Beksaç M: Thrornbopoielic eytokines in patients with iron deficiency anemia with or without thrombocytosis. Acta Ha-ematologica 2000; 103: 152-156
  12. Chanarin, J., Rothman, D. & Berry, V. Iron deficiency and its relation to folic acid status in pregnancy: results of clinical trial. British Medical Journal 1965; 1: 480-485
  13. Beard, M.E.J. & Weintraub, L.R. Hypersegmented neul-rophilic granulocytes in iron deficiency anemia. British Medical Journal 1969; 16: 161-163
  14. Westerman DA, Evans D, Metz J. Neutrophİl hyperseg-mantation in iron deficiency unemia: a case control study. BrJHacmatol. 1999; 107:512-513
  15. Davidson, W. M.: Iron metabolism and the treatment of iron deficiency anemia. In F. G. J. Hayhoe (Ed.): Lectures on Haematology, Cambrige, Cambridge University Press, 1960, p. 18
  16. Chanarm, I., Bennet, M.C. & Berry, V. Urinary excretion of histidine derivative in megaloblaslic unemia and othe