Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2009 / Cilt: 43 - Sayı: 2

Saturation biopsies for the diagnosis of prostate cancer

Prostat kanseri tanısında satürasyon biyopsileri

Pages
101–106
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review current studies concerning the use of saturation biopsy and its potential benefits particularly for selected patients with repeated negative prostate biopsies whose suspicion for prostate cancer is still clinically or biochemically relevant or for those undergoing active surveillance protocols are being assesed and discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Prostate cancer is the most diagnosed cancer in men.
📊
Key Findings & Data:In time, technical advances such as 6 core sextant biopsies, lateral zone sampling or 10 – 12 core (double sextant) biopsies came up and were introduced into clinical practice in order to improve the diagnostic value of prostate biopsies.
💡
Conclusion & Impact:In this review current studies concerning the use of saturation biopsy and its potential benefits particularly for selected patients with repeated negative prostate biopsies whose suspicion for prostate cancer is still clinically or biochemically relevant or for those undergoing active surveillance protocols are being assesed and discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Neoplazm evrelendirilmesi · Biyopsi · Prostat neoplazmları

Abstract

Prostate cancer is the most diagnosed cancer in men. If there is any suspicion of prostate cancer after PSA screening or digital rectal examination (DRE), transrectal ultrasonography guided prostate biopsies should be performed particularly for the middle aged or elderly population. Previously , prostate biopsies used to directly focus on the lesion palpated in DRE. In time, technical advances such as 6 core sextant biopsies, lateral zone sampling or 10 – 12 core (double sextant) biopsies came up and were introduced into clinical practice in order to improve the diagnostic value of prostate biopsies. Recently, investigations are focused on a new biopsy technique called saturation biopsy which includes 20 prostatic cores or more. There is a big controversy among urologists about the diagnostic value and necessity of this new technique. In this review current studies concerning the use of saturation biopsy and its potential benefits particularly for selected patients with repeated negative prostate biopsies whose suspicion for prostate cancer is still clinically or biochemically relevant or for those undergoing active surveillance protocols are being assesed and discussed.

Özet

Prostat kanseri erkeklerde en sık tanı konulan kanserdir. Özellikle orta-ileri yaş erkeklerde, PSA taramaları ya da parmakla rektal muayene sonrasında prostat kanseri şüphesi mevcut ise, tanı için yapılması gereken transrektal ultrasonografi eşliğinde prostat biyopsileri alınmasıdır. Başlangıçta prostat biyopsileri, doğrudan rektal muayenede palpe edilen lezyona yönelik uygulanmıştır. Zamanla, biyopsilerin tanısal değerini arttırmak için teknik iyileştirmeler gündeme gelmiş, bu amaçla 6 odaklı sekstant biyopsiler, lateral zon örneklemeleri, 10-12 odaklı (double-sekstant) biyopsiler klinik uygulamaya girmiştir. Son yıllarda prostat kanseri tanısında satürasyon biyopsisi olarak tanımlanan, 20 veya daha çok odaktan alınan biyopsiler üzerine çalışmalar yoğunlaşmıştır. Satürasyon biyopsilerinin tanısal değeri ve gerekliliğine dair yayınlar incelendiğinde, ürologlar arasında önemli fikir ayrılıkları oluştuğu izlenmektedir. Bu derlemede özellikle tekrarlanan prostat biyopsileri negatif sonuçlanan fakat klinik veya biyokimyasal olarak prostat kanseri şüphesi devam eden olgular ya da aktif izleme alınan olgular gibi seçilmiş hasta gruplarında satürasyon biyopsilerinin yararlılığı ele alınmıştır.

🔖

Cite This Article

ŞİRİN, H., TANRIVERDİ, O., KENDİRCİ, M., MİROĞLU, C. (2009). Saturation biopsies for the diagnosis of prostate cancer. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 43 - Sayı: 2, 101–106. https://ajindex.com/articles/363539

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics 2008 CA Cancer J Clin 2008;58:71-96 2. Zorlu F, Eser SY, Fidaner C. İzmir ilinde ürogenital kanserlerin insidans hızları (1995–1996). Üroonkoloji bülteni 2004; 1:2–9. 3. Stamey TA, McNeal JE, Freiha FS, Redwine E. Morphometric and clinical studies on 68 consecutive radical prostatectomies. J Urol. 1988;139:1235–1241. 4. Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level _____ or = 4 ng per mililiter. N Engl J Med. 2004;350 (22): 2239–46. 5. Hodge KK, McNeal JE, Terris MK, Stamey TA. Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate. J Urol. 1989;142: (1):71–74;discussion 74–75. 6. Keetch DW, Catalona WJ, Smith DS. Serial prostatic biopsies in men with persistently elevated serum prostate specific antigen values.J Urol. 1994;151:1571-74 7. Hodge KK, Mc Neal JE, Stamey TA. Ultrasound guided transrectal core biopsies of the palpably abnormal prostate. J Urol. 1989;142(1):66-70 8. Norberg M, Egevad L, Holmberg L, et al. The sextant protocol for ultrasound-guided core biopsies of the prostate underestimates the presence of cancer. Urology 1997;50 (4):562-566 9. Partin AW, Stutzman RE. Elevated prostate specific antigen, abnormal prostate evaluation on digital rectal examination and transrectal ultrasound and prostate biopsy. Urol. Clin. N Am. 1998;25:581-9 10. Stroumbakis N, Cookson MS, Reuter VE, et al. Clinical significance of repeat sextant biopsies in prostate cancer patients. Urology 1997;49 (3A suppl):113-118 11. Stamey TA. Making the most out of six systematic sextant biopsies. Urology 1995;45 (1):2–11. 12. Presti JC, Jr Chang JJ, Bhargava V, et al. The optimal systematic prostate biopsy scheme should include 8 rather than 6 biopsies: results of a prospective clinical trial. J Urol. 2000;163 (1):163–166. 13. Eskew LA, Bare LR, McCullough DL. Systematic 5 region prostate biopsy is superior to sextant method for diagnosing carcinoma of the prostate. J Urol. 1997;157:199–202. 14. Nava L, Nontori F, Consonni P, et al. Results of prospective randomised study comparing 6, 12, 18 transrectal ultrasound guided sextant biopsies in patients with elevated PSA, normal DRE and normal prostatic ultrasound. J Urol. 1997;157 (suppl):59A 15. Eskew LA, Matlaga BR, McCullough DL. Prostate biopsy indications and technique J Urol. 2003; 161(1):12–9. 16. Scattoni V, Zlotta A, Montiro