Journals / Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi / 2020 / Cilt: 11 - Sayı: 1

Factors Affecting Survival in Metastatic Tumor Treatment

Pages
82–85
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The amount of resection of metastatic tumor is significantly related with the prognosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: Brain metastatic tumors are an important complication in the general management of cancer, which often overshadows primary brain tumors.
📊
Key Findings & Data:The incidence of brain metastases is increasing due to improvements in systemic therapy and MRI screening, but basic treatment methods are lacking.Methods: The patients who were admitted to the hospital with the diagnosis of metastatic brain tumor, operated and followed up were included in our study.Results: A total of 39 patients were included to the study.
💡
Conclusion & Impact:The amount of resection of metastatic tumor is significantly related with the prognosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Beyin tumoru · metastatik tumor · sagkalim

Abstract

Background: Brain metastatic tumors are an important complication in the general management of cancer, which often overshadows primary brain tumors. The incidence of brain metastases is increasing due to improvements in systemic therapy and MRI screening, but basic treatment methods are lacking.Methods: The patients who were admitted to the hospital with the diagnosis of metastatic brain tumor, operated and followed up were included in our study.Results: A total of 39 patients were included to the study. Total resection (TR) was performed in 22 patients (56.4%), subtotal resection (STR) in 14 patients (35.8%), and only biopsy was performed in 3 patients (7.6%) due to their poor condition. When Karnofsky Performance Status (KPS) of the patients were evaluated, KPS> 70 was found in 75% of the patients.Conclusion: The patients should be treated with corticosteroids instead of continuing with emergency surgical resection, which provides sufficient time to complete preoperative preparations. The amount of resection of metastatic tumor is significantly related with the prognosis.

Özet

Amaç: Sistemik tedavi ve MR taramasındaki gelişmelernedeniyle beyin metastazlarının görülme sıklığı artmaktadır, ancak temel tedavi yöntemleri bulunmamaktadır.Yöntem: Metastatik beyin tümörü tanısı ile hastaneye yatırılanhastalar ameliyat edildi ve takip edildi.Bulgular: Çalışmaya toplam 39 hasta dahil edildi. 22 hastadatotal rezeksiyon (TR) (% 56,4), 14 hastada subtotal rezeksiyon(STR) (% 35,8), 3 hastada (% 7,6) kötü durum nedeniylesadece biyopsi yapıldı. Karnofsky Performans Durumu (KPS) değerlendirildiğinde, hastaların % 75'inde KPS> 70 bulundu.Sonuç: Hastalar preoperatif hazırlıkları tamamlamak içinyeterli zaman sağlayan acil cerrahi rezeksiyona devam etmekyerine kortikosteroidlerle tedavi edilmelidir. Metastatiktümörün rezeksiyon miktarı prognoz ile anlamlı şekilde ilişkiliolduğu görüldü.

🔖

Cite This Article

ERTILAV, K., ERCAN, S., ATAİZİ, Z. S. (2020). Factors Affecting Survival in Metastatic Tumor Treatment. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 11 - Sayı: 1, 82–85. https://ajindex.com/articles/363300

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (3)

  1. Lowery FJ, Yu D. Brain metastasis: unique challenges and open opportunities. Biochim Biophys Acta (BBA)-Reviews Cancer. 2017;1867(1):49–57.Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, et al. Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Cancer Discov. 2015;5(11):1164–77.​Lah TT, Novak M, Breznik B. Brain Malignancies: Cancer Cell Trafficking in and out of the Niches. Semin Cancer Biol [Internet]. 2019; Available from: http://www.ncbi.nlm.nih.gov/pubmed/31654711Achrol
  2. AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, et al. Brain metastases. Nat Rev Dis Prim. 2019;5(1):1–26.Owonikoko TK, Arbiser J, Zelnak A, Shu HKG, Shim H, Robin AM, et al. Current approaches to the treatment of metastatic brain tumours. Vol. 11, Nature Reviews Clinical Oncology. 2014. p. 203–22.Salehi A, Kamath AA, Leuthardt EC, Kim AH. Management of intracranial metastatic disease with laser interstitial thermal therapy. Front Oncol. 2018;8(OCT):1–6.Distefano A, Yap HY, Hortobagyi GN, Blumenschein GR. The natural history of breast cancer patients with brain metastases. Cancer. 1979;44(5):1913–8.Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. J Neurooncol. 2005;75(1):5–14.Nayak L, Lee EQ, Wen PY. Epidemiology of brain metastases. Curr Oncol Rep. 2012;14(1):48–54.Schellinger PD, Meinck HM, Thron A. Diagnostic accuracy of MRI compared to CCT in patients with brain metastases. J Neurooncol. 1999;44(3):275–81.Sze G, Milano E, Johnson C, Heier L. Detection of brain metastases: comparison of contrast-enhanced MR with unenhanced MR and enhanced CT. Am J Neuroradiol. 1990;11(4):785–91.Davis FG, Dolecek TA, McCarthy BJ, Villano JL. Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data. Neuro Oncol. 2012;14(9):1171–7.​Nussbaum ES, Djalilian HR, Cho KH, Hall WA. Brain metastases: histology, multiplicity, surgery, and survival. Cancer Interdiscip Int J Am Cancer Soc. 1996;78(8):1781–8.Zhang X, Zhang W, Cao W-D, Cheng G, Liu B, Cheng J. A review of current management of brain metastases. Ann Surg Oncol. 2012;19(3):1043–50.Sunderland GJ, Jenkinson MD, Zakaria R. Surgical management of posterior fossa metastases. J Neurooncol [Internet]. 2016;130(3):535–42. Available from: http://dx.doi.org/10.1007/s11060-016-2254-2​Kalkanis
  3. SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, et al. The role o