AI Summary & Key Takeaways
AI InsightCorpus callosum dysgenesis and associated brain anomalies should be investigated in children with developmental delay, seizures and microcephaly.
📌 3 Key Takeaways
Abstract
PURPOSE: The aim of this study was to evaluate the relationship between the types of the corpus callosum dysgenesis, the associated brain anomalies and clinical findings. MATERIALS AND METHODS: We analyzed the MR imaging findings in 169 patients with callosal dysgenesis. Corpus callosum dysgenesis was categorized into agenesis, hypogenesis and hypoplasia. The associated brain anomalies and clinical findings were evaluated. RESULTS: Associated brain anomalies were observed in 148 patients (87.5%). Twenty-one patients (12.4%) had isolated corpus callosum dysgenesis. Dysgenesis included agenesis in 22 (%13), hypogenesis in 46 (27.2%), and hypoplasia in 101 (59.7%) patients. The clinical findings were most commonly observed in patients with hypoplasia. CONCLUSION: The presence of corpus callosum dysgenesis is a strong indication of possible associated brain anomalies. Corpus callosum dysgenesis and associated brain anomalies should be investigated in children with developmental delay, seizures and microcephaly.
Özet
AMAÇ Korpus kallozum disgenezisinin değişik formları ile eşlik eden beyin anomalileri ve klinik bulgular arasındaki ilişkinin araştırılması. GEREÇ VE YÖNTEM Kallozal disgenezisli 169 olgunun MRG bulguları retrospektif olarak analiz edildi. Olgular agenezis, hipogenezis ve hipoplazi olarak sınıflandırılarak disgenezise eşlik eden beyin anomalileri ve klinik özellikler değerlendirildi. Korpus kallozum disgenezisli 148 olguda (%87.5) eşlik eden beyin anomalileri saptandı. İzole korpus kallozum disgenezisi ise 21 olguda (%12.4) mevcuttu. Yirmiiki olguda agenezis (%13), 46 olguda hipogenezis (%27.2), 101 olguda hipoplazi (%59.7) tespit edildi. Klinik bulgular en sık hipoplazili olgularda mevcuttu. SONUÇ Korpus kallozum disgenezisinin varlığı eşlik eden beyin anomalileri olabileceğinin güçlü göstergesidir. Klinik olarak gelişme geriliği, konvülziyon ve mikrosefali bulunan çocuklar korpus kallozum disgenezisi ve eşlik eden beyin anomalileri açısından araştırılmalıdır.