Journals / Tanısal ve Girişimsel Radyoloji (Yeni Adı: Dİagnostic & Intervent. Radiol) / 2004 / Cilt: 10 - Sayı: 1

Determining the aortic and renal hemodynamic effects of propofol on rabbits using Doppler ultrasonography

Propofol-fentanil anestezisinin tavşanlarda aorta ve renal hemodinami üzerine etkilerinin Doppler US ile değerlendirilmesi

Pages
48–51
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is clinically important to know that determining the changes in RI and PI during the postoperative period is not related to the propofol-fentanyl anesthesia.

📌 3 Key Takeaways

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Objective & Hypothesis:PURPOSE: The hemodynamic effects of propofol-fentanyl anesthesia was known to reduce arterial pressure and heart rate.
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Key Findings & Data:MATERIALS AND METHODS: The study was conducted on 8 male New Zaeland White strain rabbits.
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Conclusion & Impact:It is clinically important to know that determining the changes in RI and PI during the postoperative period is not related to the propofol-fentanyl anesthesia.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Tavşanlar · Fentanil · Ultrasonografi

Abstract

PURPOSE: The hemodynamic effects of propofol-fentanyl anesthesia was known to reduce arterial pressure and heart rate. We aimed to determine the effects of propofol-fentanyl anesthesia on renal artery blood flow and aorta by using Doppler ultrasonography on an animal model. MATERIALS AND METHODS: The study was conducted on 8 male New Zaeland White strain rabbits. The initial aortic and renal hemodynamic measurements were determined on animals using ketamin anesthesia. Later the right femoral arteries were cannulated for determining arterial blood pressure and pulse oximetry was followed from the ear. Propofol 5-7 mg/kg with fentanyl 1-2 µg/kg was injected via the ear vein. Doppler parameters (RI, RI, Vmax, Vmin) of the renal artery and aorta were determined after the anesthesia. RESULTS: According to the basal measurements, arterial blood pressure and breath rates declined significantly (27% and 53% respectively, p<0.05); however there were no statistical alteration of aortic and renal artery Doppler parameters. CONCLUSION: Anesthesia induced by propofol-fentanyl did not induce a statistically significant difference in Doppler parameters obtained from the renal artery and aorta. It is clinically important to know that determining the changes in RI and PI during the postoperative period is not related to the propofol-fentanyl anesthesia.

Özet

AMAÇ Anestezik ajanlardan propofol ve fentanilin hemodinamik etkileri, sistemik arter basıncı ve kalp hızında azalma ile karakterizedir. Çalışmamızda, hayvan modeli kullanarak, bu hemodinamik değişikliklerin aorta ve renal arter kan akımı üzerine olan etkilerinin, Doppler US ile belirlenmesi amaçlandı. GEREÇ VE YÖNTEM Çalışma, 8 adet "New Zealand White" cinsi erkek tavşanda planlandı. Hayvanların, bazal aorta ve renal arter Doppler parametreleri (rezistif indeks, pulsatilite indeksi, maksimal ve minimal hızlar) intramüsküler 30 mg/kg ketamin ile sedasyon sonrası elde olundu. Bu esnada sağ femoral arter kanülasyonu ile arter basıncı ve kulaktan puls oksimetre değerleri izlendi. Kulak veninden 5-7 mg/kg propofol ve 1-2 µg/kg fentanil uygulamasından sonra renal arter ve aortaya ait Doppler parametre ölçümleri tekrarlandı. Tavşanların bazal ölçüm değerlerine göre propofol ve fentanil anestezisi sırasında arter basıncı ve solunum hızında belirgin bir azalma (sırası ile %27 ve %53, p<0.05) saptanmasına rağmen aorta ve renal arter Doppler parametrelerinde istatistiksel farklılık saptanmadı. SONUÇ Propofol-fentanil anestezisi renal arter ve aorta Doppler parametrelerinde istatistiksel olarak anlamlı farklılık yaratmamaktadır; postoperatif dönemde rezistif indeks ve pulsatilite indeksi değerlerinde değişiklik saptanması durumunda bu değişikliğin propofol-fentanil anestezisi kökenli olmadığının bilinmesi klinik olarak önem taşımaktadır.

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Cite This Article

APAN, A., BİLGİLİ, K. M. Y., ÇAĞLAYAN, F. (2004). Determining the aortic and renal hemodynamic effects of propofol on rabbits using Doppler ultrasonography. Tanısal ve Girişimsel Radyoloji (Yeni Adı: Dİagnostic & Intervent. Radiol), Cilt: 10 - Sayı: 1, 48–51. https://ajindex.com/articles/363179

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