AI Summary & Key Takeaways
AI InsightBut there was no significant correlation between sCD40L and total cholesterol, LDL-cholesterol, HDLcholesterol, very LDL-cholesterol, triglycerides, 8-OHdG, F1+2 (p>0.05).Conclusion: We believe that future prospective studies to determine the increase in the level of sCD40L with a larger sample size of a pediatric population with dyslipidemias may be more helpful in predicting the risk of cardiovascular disease.
📌 3 Key Takeaways
Abstract
Aim: Coronary heart disease is one of the most common causes of death around the world. The pathological process of coronary heart disease like atherosclerosis starts in childhood. During this period thrombosis constitutes a high-risk factor. In this study, we investigated the effect of soluble CD40 ligand (sCD40L) and clotting activation on children and adolescents with hypercholesterolemia.Materials and Methods: Plasma levels of sCD40L, P-selectin, 8-hydroxy2-deoxyguanosine (8-OHdG), and prothrombin fragment 1+2 [(F) 1+2] were determined in thirty-five hypercholesterolemic patients (20 girls and 15 boys; age, median: 13 years) and forty healthy normocholesterolemic subjects (28 girls and 12 boys; age, median: 13 years).Results: No significant differences were observed between the patient group and controls in terms of age, high-density lipoprotein (HDL) cholesterol, 8-OHdG, F1+2 (p>0.05). However, there were significant differences between the two groups with respect to total cholesterol, low-density lipoprotein (LDL) cholesterol, very LDL cholesterol, triglycerides, sCD40L and P-selectin (p<0.05), which were higher in the patient group than the controls. A positive correlation was observed between sCD40L and P-selectin (p<0.05) in accordance with the Spearman correlation analysis. The correlation coefficients were 0.735 in the patient group and 0.647 in the control group. But there was no significant correlation between sCD40L and total cholesterol, LDL-cholesterol, HDLcholesterol, very LDL-cholesterol, triglycerides, 8-OHdG, F1+2 (p>0.05).Conclusion: We believe that future prospective studies to determine the increase in the level of sCD40L with a larger sample size of a pediatric population with dyslipidemias may be more helpful in predicting the risk of cardiovascular disease.
Özet
Amaç: Koroner kalp hastalığı tüm dünyadaki ölüm nedenleri arasında önemli bir yere sahiptir. Ateroskleroz gibi koroner kalp hastalığının patolojik süreci çocukluk çağı dönemlerinde başlamakta olup tromboz bu süreçte önemli bir risk faktörüdür. Bu çalışmada hiperkolesterolemili çocuk ve adölesanlarda soluble-CD40 ligand (sCD40L) ile pıhtılaşmayı aktifleştiren faktörlerin etkisi araştırılmıştır. Gereç ve Yöntemler: Plazma sCD40L, P-selektin, 8-hidroksi-2-deoksiguanozin (8-OHdG), protrombin fragmanı 1+2 [(F) 1+2] düzeyleri, 35 hiperkolesterolemili hasta (20 kız ve 15 erkek; yaş ortalaması 13 yıl) ile 40 sağlıklı kontrol (28 kız, 12 erkek; yaş ortalaması 13 yıl) grubunda değerlendirilmiştir. Bulgular: Her iki grup arasında yaş, yüksek dansiteli lipoprotein (HDL) kolesterol, 8-OHdG, F1+2 düzeyleri açısından anlamlı farklılık saptanmamıştır (p>0,05). Ancak toplam kolesterol, düşük dansiteli lipoprotein (LDL) kolesterol, çok LDL kolesterol, trigliserit, sCD40L ve P-selektin değerleri gruplar arasında anlamlı olarak farklı olup tüm bu değerler hasta grupta daha yüksek olarak ölçülmüştür (p 0,005). Sonuç: Daha geniş dislipidemili çocuk popülasyonunda yapılacak çalışmalarla sCD40L düzeyindeki artışların kardiyovasküler hastalık oluşum riskini belirlemede yardımcı olabileceğini düşünmekteyiz.