Journals / The Journal of Pediatric Research / 2017 / Cilt: 4 - Sayı: 4

A Newborn Case of "c" Subgroup Mismatch Presenting with Severe Hemolysis and Anemia

Ağır Hemoliz ve Anemiyle Başvuran "c" Subgrup Uyuşmazlıklı Bir Yenidoğan Olgusu

Pages
249–252
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, subgroup mismatch should always be kept in mind for newborns presenting with severe hemolytic anemia, and transfusion or if necessary exchange transfusion should be provided with subgroup matched blood products.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hemolysis and jaundice related to Rh incompatibility in the neonatal period has decreased substantially due to the widespread use of anti-D gammaglobulin in recent years.
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Key Findings & Data:Nevertheless, the rate of subgroup mismatch in the etiology of hemolytic diseases of the newborn has increased significantly.
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Conclusion & Impact:Therefore, subgroup mismatch should always be kept in mind for newborns presenting with severe hemolytic anemia, and transfusion or if necessary exchange transfusion should be provided with subgroup matched blood products.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hemolysis and jaundice related to Rh incompatibility in the neonatal period has decreased substantially due to the widespread use of anti-D gammaglobulin in recent years. Nevertheless, the rate of subgroup mismatch in the etiology of hemolytic diseases of the newborn has increased significantly. In this article an 8-day-old newborn infant with "c" subgroup incompatibility and presenting with severe anemia, in whom hemolysis could be controlled with intravenous immunoglobulin infusion and subgroup appropriate blood transfusion, has been presented. Scientific studies have demonstrated that the hemolytic disease of patients who don't have major blood group incompatibility but carry anti-C antibodies can be rather serious. Therefore, subgroup mismatch should always be kept in mind for newborns presenting with severe hemolytic anemia, and transfusion or if necessary exchange transfusion should be provided with subgroup matched blood products.

Özet

Son yıllarda anti-D gamaglobulin kullanımının yaygınlaşması ile birlikte yenidoğan döneminde Rh uyuşmazlıklarına bağlı hemoliz ve sarılık büyük ölçüde azalmıştır. Bununla beraber subgrup uyuşmazlıklarının yenidoğanın hemolitik hastalığı etiyolojisindeki oranı önemli ölçüde artmıştır. Bu makalede; postnatal 8. gününde, ağır anemiyle seyreden, intravenöz immünoglobulin ve subgrup uygun kan transfüzyonu ile hemolizi kontrol altına alınan bir subgrup "c" uyuşmazlığı olgusu sunulmuştur. Bilimsel çalışmalar, majör kan grubu uyuşmazlığı bulunmayan, ancak anti-C antikorları taşıyan olgularda hemolitik hastalığın oldukça ciddi seyredebildiğini göstermiştir. Bu nedenle şiddetli hemolitik anemi ile kliniğe başvuran yenidoğanlarda her zaman subgrup uyuşmazlıkları akılda bulundurulmalı, subgrup uygun kan ürünleri ile transfüzyonları ve gerekirse kan değişimleri sağlanmalıdır.

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Cite This Article

YANGIN, E. E., ALKAN, S. Ö., ÇOLAK, R., ÇELİK, K., OLUKMAN, Ö., ÇALKAVUR, Ş. (2017). A Newborn Case of "c" Subgroup Mismatch Presenting with Severe Hemolysis and Anemia. The Journal of Pediatric Research, Cilt: 4 - Sayı: 4, 249–252. https://ajindex.com/articles/362976

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References (14)

  1. Moise Kenneth J. Hemolytic disease of the fetus and newborn. Creasy and Resnik's Maternal - Fetal Medicine, Principles and Practice, 2014;558-68
  2. Zipursky A, Bowman JM. Isoimmune hemolytic diseases. In: Nathan DG, Oski FA (eds). Hematology of Infancy and Childhood, 4th ed. Philadelphia, WB Saunders C, 1993;44- 73
  3. Moise KJ. Fetal anemia due to non-Rhesus-D red-cell alloimmunization. Semin Fetal Neonatal Med 2008;13:207- 14
  4. Özkaya H, Bahar A, Özkan A, Kandemir F, Göçmenİ, Mete Z. Neonatal Period anemia with symptoms that minor blood group (anti-C, anti-E) nonconformity connected Hemolytic Disease. Turk Pediatri Ars 2000;35:30-5
  5. Rath ME, Smits-Wintjens VE, Walther FJ, Lopriore E. Hematological morbidity and management in neonates with hemolytic disease due to red cell alloimmunization. Early Hum Dev 2011;87:583-8
  6. Geifman-Holtzman O, Wojtowycz M, Kosmas E, Artal R. Female alloimmunization with antibodies known to cause hemolytic disease. Obstet Gynecol 1997;89:272-5
  7. Farnault L, Garcia-Meric P, Cortey A, Arnaud F. Fetomaternal anti-RH3, -4 (anti-E and anti-c) rhesus isoimmunization: a case report. Arch Pediatr 2011;18:176-82
  8. Van Dijk BA, Hirasing RA, Overbeeke MA. Hemolytic disease of the newborn and irregular blood group antibodies in the Netherlands: prevalence and morbidity. Ned Tijdschr Geneeskd 1999;143:1465-9
  9. Kubo S, Ariga T, Tsuneta H, Ishii T. Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis? A successful case of haemolytic disease due to rhesus (c + E) incompatibility. Eur J Pediatr 1991;150:507-8
  10. Dajak S, Culic S, Stefanovic V, Lukacevic J. Relationship between previous maternal transfusions and haemolytic disease of the foetus and newborn mediated by non-RhD antibodies. Blood Transfus 2013;11:528-32
  11. Gökçe İK, Güzoğlu N, Öncel MY, Çalışçı E, Canpolat FE, Dilmen U. A Hemolytic Disease due to Minor Blood Group (Anti-C and Anti-E) Incompatibility Leading to Symptomatic Anemia in the Neonatal Period. Turkish Journal of Pediatric Disease 2014;1:32-4
  12. Louis D, More K, Oberoi S, Shah PS. Intravenous immunoglobulin in isoimmune haemolytic disease of newborn: an updated systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 2014;99:325-31
  13. Thakral B, Agrawal SK, Dhawan HK, Saluja K, Dutta S, Marwaha N. First report from India of haemolytic disease of newborn by anti-c and anti-E in Rh (D) positive mothers. Hematology 2007;12:377-80
  14. Wu KH, Chu SL, Chang JG, Sh