Journals / The Journal of Pediatric Research / 2016 / Cilt: 3 - Sayı: 4

Beyin Sapı ve Medulla Spinalis Tutulumu ve Normal Laktat ile Seyreden Lökoensefalopati: Olgu Sunumu

Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and Normal Lactate: Case Report

Pages
215–218
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this case report, we describe a patient with LBSL and normal lactate levels on MRS.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Leukoencephalopathy with brain stem and spinal cord involvement and high lactate (LBSL) include cerebral white matter, brain stem and spinal cord tract involvement on magnetic resonance imaging.
📊
Key Findings & Data:Increased lactate levels on magnetic resonance spectroscopy (MRS) has been reported.
💡
Conclusion & Impact:In this case report, we describe a patient with LBSL and normal lactate levels on MRS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Leukoencephalopathy with brain stem and spinal cord involvement and high lactate (LBSL) include cerebral white matter, brain stem and spinal cord tract involvement on magnetic resonance imaging. Increased lactate levels on magnetic resonance spectroscopy (MRS) has been reported. In this case report, we describe a patient with LBSL and normal lactate levels on MRS.

Özet

Manyetik rezonans görütülemede serebral beyaz madde, beyin sapı ve medulla spinalis traktuslarının tutulumu, beyin sapı ve medulla spinalis tutulumu ve laktat yüksekliği ile seyreden lökoensefalopati (LBSL) için tanı koydurucudur. Manyetik rezonans spektroskopide laktat piki bildirilmiş olsa da bu olgu sunumunda normal laktat seviyeleri gösteren LBSL özellikleri tartışılmıştır.

🔖

Cite This Article

ÇOLAK, E., ERASLAN, C. (2016). Beyin Sapı ve Medulla Spinalis Tutulumu ve Normal Laktat ile Seyreden Lökoensefalopati: Olgu Sunumu. The Journal of Pediatric Research, Cilt: 3 - Sayı: 4, 215–218. https://ajindex.com/articles/362851

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (6)

  1. Scheper GC, van der Klok T, van Andel RJ, et al. Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Nat Genet 2007;39:534- 9. Bonnefond L, Fender A, Rudinger-Thirion J, Giege R, Florentz C, Sissler M. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Biochemistry 2005;44:4805-16.
  2. Delarue M, Poterszman A, Nikonov S, Garber M, Moras D, Thierry JC. Crystal structure of a prokaryotic aspartyl tRNA- synthetase. EMBO J 1994;13:3219-29. van der Knaap MS, van der Voorn P, Barkhof F, et al. A new leukoencephalopathy with brainstem and spinal cord involvement and high lactate. Ann Neurol 2003;53:252-8. Scheper GC, van der Klok T, van Andel RJ, et al. Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Nat Genet 2007;39:534- 9. Steenweg ME, van Berge L, van Berkel CG, et al. Early- onset LBSL: how severe does it get? Neuropediatrics 2012;43:332-8.
  3. Petzold GC, Bohner G, Klingebiel R, Amberger N, van der Knaap MS, Zschenderlein R. Adult onset leucoencephalopathy with brain stem and spinal cord involvement and normal lactate. J Neurol Neurosurg Psychiatry 2006;77:889-91.
  4. Labauge P, Roullet E, Boespflug-Tanguy O, et al. Familial, adult onset form of leukoencephalopathy with brain stem and spinal cord involvement: inconstant high brain lactate and very slow disease progression. Eur Neurol 2007;58:59- 61. Tavora DG, Nakayama M, Gama RL, Alvim TC, Portugal D, Comerlato EA. Leukoencephalopathy with brainstem and spinal cord involvement and high brain lactate: report of three Brazilian patients. Arq Neuropsiquiatr 2007;65:506-11.
  5. Linnankivi T, Lundbom N, Autti T, et al. Five new cases of a recently described leukoencephalopathy with high brain lactate. Neurology 2004;63:688-92. van Berge L, Hamilton EM, Linnankivi T, et al. Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation: clinical and genetic characterization and target for therapy. Brain 2014;137:1019- 29. Akçay AA, Keskin S, Gökben S. A case of slowly porgressive encephalopahty. Annual meeting of European Academy of Childhood Disability and Joint of National Pediatric Neurology Congress. İstanbul: Poster presentations 2012.
  6. Serkov SV, Pronin IN, Bykova OV, et al. Five patients with a recently described novel leukoencephalopathy with brainstem and sp