Journals / The Journal of Pediatric Research / 2016 / Cilt: 3 - Sayı: 1

Frequency of Asthma and Allergic Disorders in Children with Hepatitis A Seropositivity

Hepatit A Seropozitif Çocuklarda Astım ve Alerjik Hastalıkların Sıklığı

Pages
13–17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Significant differences between the two groups in terms of allergic symptoms were observed.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: An inverse association between markers of exposure to orofecal pathogens such as hepatitis A and allergic disease has been reported.
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Key Findings & Data:Materials and Methods: This study was performed in 499 children admitted to our Hospital and in whom we determined specific IgG in serum to hepatitis A virus (HAV).
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Conclusion & Impact:Significant differences between the two groups in terms of allergic symptoms were observed.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: An inverse association between markers of exposure to orofecal pathogens such as hepatitis A and allergic disease has been reported. However, the findings of studies have not been consistent. In this study we compared to the frequency of allergic symptoms and asthma in children with hepatitis A seropositive and seronegative. Materials and Methods: This study was performed in 499 children admitted to our Hospital and in whom we determined specific IgG in serum to hepatitis A virus (HAV). The demographical findings of the children were recorded. They were examined by using ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire. Results: The mean age of 449 children was 9.28±2.24 (1-16y) years. 47.7% of the children were female and 52.3% were male. Anti-HAV IgG serology was found positive in 261 children and negative in 238 children. The frequency of physician-diagnosed asthma that kept them awake at night <=1 per week on average by this itchy rash were found to be high in children with hepatitis A seronegative. Attacks of wheezing in the last 12 months, speech-limiting wheeze and rhinoconjunctivitis in the last 12 months were high in children with hepatitis A seropositive.Conclusion: The frequency of physician-diagnosed asthma is higher in children with hepatitis A seronegative. Significant differences between the two groups in terms of allergic symptoms were observed.

Özet

Amaç: Orofekal yolla bulaşan Hepatit A gibi enfeksiyonların alerjik hastalıklara eğilimi azalttığı bildirilmiştir. Ancak konu ile ilgili çalışmaların sonuçları açık değildir. Çalışmamızda Hepatit A seropozitif ve seronegatif çocuklarda astım ve alerjik hastalık belirtilerinin sıklığını karşılaştırdık. Gereç ve Yöntemler: Çalışma hastanemize çeşitli nedenler ile başvuran ve Hepatit A virüs (HAV) serolojisi belirlenmiş 499 çocukta yapılmıştır. Çalışmaya alınan çocukların demografik özellikleri kaydedildi. Astım ve alerjik hastalıkların belirtileri International Study of Asthma and Allergy in Childhood (ISAAC) soru formu kullanılarak kaydedildi. Bulgular: Dört yüz doksan dokuz çocuğun yaş ortalamaları 9,28±2,24 yıl olup %47,7'si kız, %52,3'ü erkek idi. İki yüz altmış bir çocukta Anti HAV IgG serolojisi pozitif; 238'inde negatif bulundu. Doktor tanılı astım oranı ve kaşıntı nedeni ile haftada <=1 uykudan uyanma anti HAV IgG negatif çocuklarda daha yüksekti. Son 12 ayda hışıltı, son 12 ayda atak sıklık sayısı, hışıltı nedeniyle konuşma bozukluğu ve son 12 ayda rinokonjuktivit sıklığı anti HAV IgG pozitif çocuklarda istatistiksel olarak anlamlı yüksek bulundu. Sonuç: Hepatit A seronegatif çocuklarda doktor tanılı astım sıklığı seropozitif olanlara göre istatistiksel anlamlı olarak daha yüksek bulundu. Alerjik semptomlar açısından her iki grup arasında önemli farklılıklar gözlenmedi.

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Cite This Article

KARADUMAN, A., DURU, H. N. S., ÇİVİLİBAL, M., ŞAHİN, K., ELEVLİ, M. (2016). Frequency of Asthma and Allergic Disorders in Children with Hepatitis A Seropositivity. The Journal of Pediatric Research, Cilt: 3 - Sayı: 1, 13–17. https://ajindex.com/articles/362827

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