Journals / The Journal of Breast Health / 2015 / Cilt: 11 - Sayı: 3

A Retrospective Comparative Study of Image-Guided Excisional Biopsy in HighRisk Non-Palpable Breast Lesions: Predictive Factors for Malignancy

Görüntüleme Kılavuzluğunda Eksizyonel Biyopsi Yapılan Yüksek Riskli Non-Palpabl Meme Lezyonları Retrospektif Karşılaştırmalı Çalışması: Malignite Öngören Faktörler

Pages
132–137
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In our study; we concluded that, preoperative BI-RADS categorization (US and MM) is correlated with histopathologic findings after surgery and imaging-guided breast surgery is effective for diagnosis of early-stage breast carcinoma.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The use of mammography (MM) in breast cancer screening programs has been increasing in recent years.
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Key Findings & Data:Thus, increasing the number of detected nonpalpable breast cancer patients, through early diagnosis and treatment also increased survival rates.
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Conclusion & Impact:Conclusion: In our study; we concluded that, preoperative BI-RADS categorization (US and MM) is correlated with histopathologic findings after surgery and imaging-guided breast surgery is effective for diagnosis of early-stage breast carcinoma.
🔬Design:Review & Systematic Survey
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The use of mammography (MM) in breast cancer screening programs has been increasing in recent years. Thus, increasing the number of detected nonpalpable breast cancer patients, through early diagnosis and treatment also increased survival rates. In our study, we wanted to share the factors about imaging-guided exicional biopsies for non-palpable breast lesions in postoperative proven breast carcinoma patients. Materials and Methods: The surgical data were reviewed for 83 patients with non-palpabl high-risk breast lesions undergoing imaging-guided surgery in our department between January, 2006 and May, 2011. Histopathologic results and age, ultrasound(US) results, MM image results, BI-RADS categorization, localization of lesion(quadrant) were assessed and factors for predicting malignity were detected. Results: Median age was 52 (age range 32-80 years). 29 (34,9%) of patients were malign in histopathologic results. In four patient, re-excision performed because of positive surgical margins. Axillary examination results were normal in 24 (82,7%) of malignant patients. In MM examination; microcalcifications and nodular opasity were diagnosed in 74,6% of patients before surgery. There were no differance about malignity in these groups after surgery (p:0,428). 59% and 32,7% of patients were BI-RADS 4 and 3, respectively. Postoperative diagnosed malignancies in BI-RADS 4 group were significantly higher than BI-RADS 3 group (p:<0,001). Conclusion: In our study; we concluded that, preoperative BI-RADS categorization (US and MM) is correlated with histopathologic findings after surgery and imaging-guided breast surgery is effective for diagnosis of early-stage breast carcinoma.

Özet

Amaç: Meme kanseri tarama programlarında mamografinin (MM) kullanımının yaygınlaşması sonucu non-palpabl meme kanserinin artışıyla birlikte sağkalım oranları da önemli ölçüde artmıştır. Çalışmamızda non-palpabl meme lezyonlarının çeşitli tekniklerle işaretleme sonrası eksizyonu sonucu, histopatolojik sonuçlarda karsinom saptanmasına işaret eden faktörler değerlendirilmiştir. Yöntem ve Gereçler: Ocak 2006-Mayıs 2011 yılları arasında yüksek riskli nonpalpabl meme lezyonlarında işaretleme teknikleriyle cerrahi eksizyon yapılan 83 hasta incelendi. Histopatolojik sonuçlar ile yaş, ultrason sonuçları, mamografi sonuçları, BI-RADS kategorizasyonu, şüpheli lezyonun memedeki lokalizasyonu (kadran) prediktif risk faktörleri karşılaştırılarak maligniteyi öngören faktörler saptandı. Bulgular: Hastaların ortanca yaşı 52 (yaş aralığı, 32-80) idi. 29 hasta malign (%34,9) olarak saptanmıştır. 4 hastada (%13,7) cerrahi sınırların pozitif gelmesi nedeniyle reeksizyon uygulanmıştır. Malignite saptanan hastaların %82,7 si (n=24) aksilla negatif hastalardır. Hastaların mamografi sonuçlarında en sık olarak %37,3 mikrokalsifikasyon (n=31, ppd=%42), %37,3 nodüler opasite (n=31, ppd=%33) saptanmıştır. Malignite saptanmasında aralarında istatistiki fark saptanmamıştır (p=0,428). BI-RADS skoru dağılımı %59 BIRADS 4 (n=49, ppd=%53), %32,5 BI-RADS 3 (n=27, ppd=%11) olarak saptanmıştır. Çalışmamızdaki BI-RADS 4 lezyonların malignite oranı BIRADS 3 ten istatistiksel olarak anlamlı bir şekilde fazladır (p=0,001). Sonuç: Çalışmamıza göre BI-RADS kategorizasyonu(US ve MM) cerrahi sonrası histopatolojik bulgularla uyumludur ve işaretleme ile nonpalpabl meme lezyonlarının cerrahi olarak çıkarılması erken evre meme kanseri tanısında etkilidir.

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Cite This Article

İFLAZOĞLU, N., ÜREYEN, O., ATAHAN, M. K., MERAL, U. M., SEZGİN, G., TARCAN, E. (2015). A Retrospective Comparative Study of Image-Guided Excisional Biopsy in HighRisk Non-Palpable Breast Lesions: Predictive Factors for Malignancy. The Journal of Breast Health, Cilt: 11 - Sayı: 3, 132–137. https://ajindex.com/articles/362177

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