Journals / The Journal of Breast Health / 2015 / Cilt: 11 - Sayı: 3

Comparison of Clinical and Pathological Differences of Breast Cancer Patients under 35 and above 55 Years of Age

35 Yaş Altı Genç ve 55 Yaş Üstü Postmenopozal Meme Kanserli Hastaların Klinik ve Patolojik Farklılığının Karşılaştırılması

Pages
123–127
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In addition, oncoplastic and reconstructive approaches were significantly higher in young patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, we aimed to evaluate the clinical, pathologic and management differences between breast cancer patients under 35 years of age and postmenopausal patients above 55 years of age.
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Key Findings & Data:Materials and Methods: Patients who were operated on for breast cancer between November 2003 and March 2013 in our hospital were retrospectively analyzed.
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Conclusion & Impact:In addition, oncoplastic and reconstructive approaches were significantly higher in young patients.
🔬Design:Research Article
📍Scope:2003 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, we aimed to evaluate the clinical, pathologic and management differences between breast cancer patients under 35 years of age and postmenopausal patients above 55 years of age. Materials and Methods: Patients who were operated on for breast cancer between November 2003 and March 2013 in our hospital were retrospectively analyzed. Patients were separated into two Groups according their age; Group 1 (<35 years) and Group 2 (>55 years). Results: 94 patients with breast cancer, 45 patients in Group 1 and 49 patients in Group 2, were included in the study. The mean follow-up was 51 (19-121) months and 50 (19-120) months in Groups 1 and 2, respectively. Stages of breast cancer at the time of diagnosis were similar between the two groups. The groups were similar in terms of rates of re-excision (p=0.42), local recurrence (p=0.34) and solid organ metastases (p=0.182). The number of oncoplastic and reconstructive procedures were higher in Group 1 (p=0.04). Regarding pathological results, the rate of grade 3 tumors, those with Ki-67>12 and triple negative breast cancer were found to be higher in Group 1. In addition, the number of patients receiving chemotherapy was significantly higher in Group 1 (p=0.03). Conclusion: Oncologic results were similar between young patients and postmenopausal patients. Nevertheless, tumor biology was found to be worse in young patients. In addition, oncoplastic and reconstructive approaches were significantly higher in young patients.

Özet

Amaç: Bu çalışmamızın amacı 35 yaş ve altı meme kanserli kadınların klinik, patolojik, tedavi uygulamaları ve sonuçlarının 55 yaş ve üstü postmenopozal kadınlardaki meme kanseriyle karşılaştırmak ve bu genç grubun farklılığı incelemektir. Yöntem ve Gereçler: Kasım 2003-Mart 2013 tarihleri arasında hastanemiz genel cerrahi kliniğinde meme kanseri nedeniyle ameliyat edilen ve verilerine ulaşılabilen genç yaş (≤35 yaş) (grup 1) ve postmenopozal (≥55 yaş) meme kanserli kadın hastaların (grup 2) verileri geriye dönük incelendi. Bulgular: Grup 1de 45 hasta ve grup 2de 49 hasta olmak üzere izlemi tarafımızca yapılan toplam 94 meme kanserli kadın çalışmaya alındı. 35 yaş ve altı meme kanseri oranı tüm meme kanserli olguların %8,2 (59 olgu) idi. Ortanca izlem süresi grup 1de 51 (19-121) ay ve grup 2de 50 (19-120) ay olarak saptandı. Tanı sırasında gruplar arasında meme kanseri evreleri benzer olarak bulunmuştur. Onkolojik olarak reeksizyon oranı (p=0,42), yerel yineleme oranı (p=0,34), ve uzak metastaz oranı (p=0,182) açısından gruplar arasında istatistiksel fark bulunmamıştır. Grup 1de onkoplastik ve rekonstrüktif tekniklerin kullanım oranı daha yüksektir (p=0.04). Grup 1de derece 3 oranı, Ki 67 >12 oranı ve üçlü negatif meme kanseri oranı daha yüksek bulunmuştur. Genç yaştaki hastalar daha yüksek oranda kemoterapi aldığı saptanmıştır (p=0.03). Sonuç: Genç yaştaki ve postmenopozal kadınlarda meme kanseri onkolojik sonuçlar açısından benzerdir. Genç kadınlardaki meme kanserleri postmenopozal olanlardan biyolojik olarak daha kötü özelliklere sahiptir. Bu hasta grubunda onkoplastik ve rekonstrüktif yaklaşımlar daha yüksektir.

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Cite This Article

EMİROĞLU, M., KARAALİ, C., SERT, İ., SALİMOĞLU, S., UĞURLU, L., AKSOY, S. Ö., AYDIN, C. (2015). Comparison of Clinical and Pathological Differences of Breast Cancer Patients under 35 and above 55 Years of Age. The Journal of Breast Health, Cilt: 11 - Sayı: 3, 123–127. https://ajindex.com/articles/362022

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