SavedAdd your journal

Journals / Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi / 2013 / Cilt: 4 - Sayı: 2

Using and Selection Criterias of Laboratory Animals with Experimental Purpose in Endodontics

Endodontik Çalışmalarda Deney Hayvanlarının Kullanımı ve Seçim Kriterleri

İHSAN FURKAN ERTUĞRUL
Murat MADEN
EKİM ONUR ORHAN
Pages
81–90
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We concluded that the animal experimants could be conducted on rats, mices and ferrets except the stem cell researches which must be done on dogs as an animal model in endodontics.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Animal experimentation is the use of animals in scientific research.
📊
Key Findings & Data:Animal experimants help scientists understand diseases that exist animals and humans, for example new medicines oe new surgical techniques.
💡
Conclusion & Impact:We concluded that the animal experimants could be conducted on rats, mices and ferrets except the stem cell researches which must be done on dogs as an animal model in endodontics.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Laboratuvar Hayvanları · Hayvan Deneyleri · Endodonti

Abstract

Animal experimentation is the use of animals in scientific research. Animal experimants help scientists understand diseases that exist animals and humans, for example new medicines oe new surgical techniques. Animal models have an significiant place in endodontics. Planning the animal experiments, choosing the animal models and the applying ethical principles, in researchs have been included in this review. We concluded that the animal experimants could be conducted on rats, mices and ferrets except the stem cell researches which must be done on dogs as an animal model in endodontics.

Özet

Hayvan deneyleri, hayvanların bilimsel çalışmalarda kullanılması olarak tanımlanır. Bu deneyler insanlar ve hayvanlarda var olan hastalıklar hakkında bilgi edinilmesinde, yeni bir madde veya yeni bir cerrahi tekniğin test edilmesinde bilim adamlarına yardımcı olmaktadır. Hayvan modelleri endodontide önemli bir yer tutmaktadır. Bu derlemede, bir hayvan çalışması planlarken hayvan modelinin seçimi ve çalışmalarda etik prensiplerin uygulanması ele alınmıştır. Sonuç olarak endodontide kök hücre çalışmaları dışındaki dışındaki bütün çalışmalar fare, rat ve dağ gelincikleri üzerinde yapılabilir.

🔖

Cite This Article

ERTUĞRUL, İ. F., MADEN, M., ORHAN, E. O. (2013). Using and Selection Criterias of Laboratory Animals with Experimental Purpose in Endodontics. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 4 - Sayı: 2, 81–90. https://ajindex.com/articles/360445

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Başaran A.Deney Hayvanları. 1inci baskı.48, Nisan Kitabevi, Eskişehir, 2003.
  2. Baumgartner JC, Falkler WJ, Beckerman T. Experimentally induced infection by oral anaerobic microorganisms in a mouse model. Oral Microbiol Immunol 1992; 7(4):253–256.
  3. Feuille F, Ebersole JL, Kesavalu L, Stepfen MJ, Holt SC. Mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a murine lesion model. potential synergistic effects on virulence, Infect Immun 1996; 64 (6): 2094–2100.
  4. Sobrinho AP, Barros MH, Nicoli JR, Carvalho MA, Farias LM, Bambirra EA, Bahia MG, Vieira EC. Experimental root canal infections in conventional and germ–free mice. J Endod 1998; 24 (6): 405–408.
  5. Atkinson MA, Leiter EH. The NOD mouse model of type I diabetes: as good as it gets?. Nature Med. 1999; 5 (6): 601–604.
  6. Fouad A, Barry J, Russo J, Radolf J, Zhu Q. Periapical lesion progression with controlled microbial inoculation in a type I diabetic mouse model. J Endod 2002; 28 (1): 8–16.
  7. Moretton TR, Brown CE Jr, Legan JJ, Kafrawy AH. Periapical Lesion Progression with Controlled Microbial Inoculation in a Type I Diabetic Mouse Model. J Biomed Mater Res 2000; 52 (3): 528–533. de Melo Maltos SM, Ribeiro Sobrinho AP, Silva FV, Nicoli JR, Roque de Carvalho MA, Vieira LQ, de Macêdo Farias L. Bacterial concentrations determine the ability to implant in the root canal system and translocate to lymph nodes in germ–free mice. J Endod 2003; 29 (1): 24–27.
  8. Faria G, Celes MR, De Rossi A, Silva LA, Silva JS, Rossi MA. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured I929 fibroblasts. J Endod 2007;33(6):715–722
  9. Rezende TM, Vieira LQ, Sobrinho AP, Oliveira RR, Taubman MA, Kawai T. The influence of mineral trioxide aggregate on adaptive immune responses to endodontic pathogens in mice. J Endod 2008; 34 (9): 1066–1071.
  10. Mutoh N, Watabe H, Chieda K, Tani–Ishii N. Expression of Toll–like receptor 2 and 4 in inflamed pulp in severe combined immunodeficiency mice. J Endod 2009; 35 (7): 975–980.
  11. Alshwaimi E, Purcell P, Kawai T, Sasaki H, Oukka M, Campos–Neto A, Stashenko P. Regulatory T cells in mouse periapical lesions. J Endod 2009; 35 (9): 1229–1233.
  12. Metzger Z, Lin YY, Dimeo F, Ambrose WW, Trope M, Arnold RR. Synergistic pathogenicity of Porphyromonas gingivalis and Fusobacterium nucleatum in the mouse subcutaneous chamber model. J Endod 2009; 35 (1): 86–94.
  13. Garlet TP, Fukada SY, Saconato IF, Avila–Campos MJ, da Silva TA, Garlet GP, Cunha Fde Q. CCR2 deficiency result