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Journals / Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi / 2017 / Cilt: 8 - Sayı: 2

Medication Related Osteonecrosis of The Jaws (Mronj): Review

İlaca Bağlı Olarak Görülen Çene Kemiklerinde Görülen Osteonekroz (Mronj): Derleme

TAYFUN YAZICI
MEHMET FATİH ŞENTÜRK
GÜLPERİ KOÇER
Pages
50–57
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of the present review was to analyze the etiology, clinical manifestations, risk factors, radiologic features and different treatment strategies of MRONJ.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Bisphosphonates are synthetic analogues of pyrophosphates used for the treatment of hypercalcemia in patients with malignancies and bone metastasis and for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, and in the treatment of osteoporosis.
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Key Findings & Data:Bisphosphonates related osteonecrosis of the jaw cases accelarated at the end of 2003.
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Conclusion & Impact:The aim of the present review was to analyze the etiology, clinical manifestations, risk factors, radiologic features and different treatment strategies of MRONJ.
🔬Design:Review & Systematic Survey
📍Scope:2003 Verileri
⚙️Variables:Domain Parameters

Abstract

Bisphosphonates are synthetic analogues of pyrophosphates used for the treatment of hypercalcemia in patients with malignancies and bone metastasis and for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, and in the treatment of osteoporosis. Bisphosphonates related osteonecrosis of the jaw cases accelarated at the end of 2003. Due to some medications, American Association of Oral and Maxillofacial Surgery modified the concept as medication related osteonecrosis of the jaw (MRONJ) in 2014. The aim of the present review was to analyze the etiology, clinical manifestations, risk factors, radiologic features and different treatment strategies of MRONJ.

Özet

Bifosfonatlar pirofosfatların sentetik analogları olup; malignensilere bağlı olarak gelişen hiperkalsemi, multipl myeloma, kemik metastazı tedavisinin yanında osteoporöz tedavisi için kullanılan ilaçlardır. Bisfosfanat kullanımına bağlı çenelerde görülen osteonekroz olguları 2003 yılının sonlarından itibaren hızla artış göstermiştir. 2014 yılında Amerikan Çene Yüz Cerrahisi Derneği tarafından tabloya katılan bazı ilaçlarla tablo ilaç kullanımına bağlı olarak çene kemiklerinde gelişen osteonekroz olarak değişmiştir. Bu derlemenin amacı ilaç kullanımına bağlı olarak çene kemiklerinde gelişen osteonekroz olgularının etiyolojisini, klinik ve radyolojik bulgularını, risk faktörlerini ve farklı tedavi seçeneklerini irdelemektir.

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Cite This Article

YAZICI, T., ŞENTÜRK, M. F., KOÇER, G. (2017). Medication Related Osteonecrosis of The Jaws (Mronj): Review. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 8 - Sayı: 2, 50–57. https://ajindex.com/articles/360375

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