Stroke in young adult with MELAS syndrome

Objective & Hypothesis:MELAS syndrome, a rare mitochondrial disorder, is characterized by mitochondrial encephalopathy, lactic acidosis, recurrent stroke-like episodes.

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Key Findings & Data:A 20 year-old right handed male was admitted to our department with lethargy and left hemiparesis.

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Conclusion & Impact:In differential diagnosis of voung stroke we must carefully consider MELAS.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Tanı · ayırıcı · Mitokondriyal hastalıklar

Abstract

MELAS syndrome, a rare mitochondrial disorder, is characterized by mitochondrial encephalopathy, lactic acidosis, recurrent stroke-like episodes. Seizures, headaches, nausea and vomiting, exercise intolerance, and ragged-red fibers may be seen. A 20 year-old right handed male was admitted to our department with lethargy and left hemiparesis. In past history, he had convulsion for three months. He had acut-subacute infarct at left anterior frontal, temporo-parietal and posterior occipital region. Based on history, physical and neurological examinations, neuroimaging, histopathological studies, he WAS diagnosed as MELAS syndrome. This very rare finding has been demonstrated in this paper. In differential diagnosis of voung stroke we must carefully consider MELAS.

Özet

MELAS Sendromu; mitokondrial ensefalopati, laktik asidoz, tekrarlayan inme benzeri epizodlarla karekterize nadir görülen mitokondrial bir hastalıktır. Nöbetler, başağrısı, bulantı, kusma, egzersiz intoleransı ve ragged red fiber görülür. 20 yaşında, sağ elini kullanan erkek hasta letarji ve sol hemiparezi bulguları ile kliniğimize başvurdu. Öyküsünde 3 aydır konvülziyonu vardı. Radyolojik incelemesinde, sol anterior frontal, temporo-parietal ve posterior oksipital bölgede akut-subakut enfarktı mevcuttu. Öykü, fizik ve nörolojik muayene, görüntüleme, histopatolojik çalışmalar sonucunda olgu MELAS sendromu olarak tanındı. Genç inmenin ayırıcı tanısında MELAS dikkatle göz önünde tutulmalıdır.

Keywords

Tanı ayırıcı Mitokondriyal hastalıklar MELAS sendromu Serebrovasküler olay Diagnosis Differential Mitochondrial Diseases MELAS Syndrome Cerebrovascular Accident

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Cite This Article

KOÇ, A. F., ÖZEREN, A., SARICA, Y., ZORLUDEMİR, S., ÖZCAN, F. (2004). Stroke in young adult with MELAS syndrome. Türk Serebrovasküler Hastalıklar Dergisi, Cilt: 10 - Sayı: 3, 135–138. https://ajindex.com/articles/357823

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