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Journals / Anadolu Psikiyatri Dergisi / 2002 / Cilt: 3 - Sayı: 4

The effects of protein depletion on mood and plasma serotonin level in euthymic bipolar I patients treated with lithium or carbamazepine

Lityum ya da karbamazepin kullanmakta olan ötimik bipolar I hastalarda protein kısıtlamasının mizaç ve plazma serotonin düzeyi üzerine etkileri

M. Tayfun TURAN
Yarkın ÖZCAN
Ertuğrul EŞEL
İnci KARAKÜÇÜK
Mustafa BAŞTÜRK
Pages
206–211
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: After the protein-depleted diet it was found that plasma 5-HT level of Li treated group was significantly lower than that of control group.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: It is not clear whether or not brain serotonin (5-HT) function mediates the therapeutic effects of lithium (Li) or carbamazepine (CZ) in bipolar disorder, including prevention of relapse.
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Key Findings & Data:Method: Thirty-two patients who met DSM-IV criteria for bipolar I disorder and 10 healthy volunteers participated in this study.
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Conclusion & Impact:Results: After the protein-depleted diet it was found that plasma 5-HT level of Li treated group was significantly lower than that of control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Karbamazepin · Diyet tedavisi · Lityum

Abstract

Objective: It is not clear whether or not brain serotonin (5-HT) function mediates the therapeutic effects of lithium (Li) or carbamazepine (CZ) in bipolar disorder, including prevention of relapse. The aim of present study was to examine the effects of protein depletion on mood and serotonergic function in bipolar I patients who were symptomatically stable on Li or CZ. Method: Thirty-two patients who met DSM-IV criteria for bipolar I disorder and 10 healthy volunteers participated in this study. Twenty-two of the patients were on Li treatment while the others were on CZ. All subjects underwent a protein-depleted diet for 1 week. Plasma 5-HT and free L-tryptophan (L-TRP) levels were measured before and after the protein-depleted diet. Symptoms were also evaluated after the protein-depleted diet. Results: After the protein-depleted diet it was found that plasma 5-HT level of Li treated group was significantly lower than that of control group. There were no significant changes in mood. Conclusion: The disruption of 5-HT function caused by protein depletion may be insufficient to cause mood changes in bipolar I patients stabilized on Li or CZ treatment.

Özet

Amaç: Beyin serotoninin (5-HT), bipolar bozuklukta atakları da önleme dahil, lityum (Li) ya da karbamazepinin (KZ) etkilerine iştirak edip etmediği belli değildir. Bu çalışmanın amacı, Li ya da KZ kullanmakta olan ötimik bipolar I hastalarda protein kısıtlamasının mizaç ve serotonerjik sistem işlevi üzerindeki etkilerini araştırmaktı. Yöntem: Bipolar I bozukluk için DSM-IV kriterlerini dolduran 32 hasta ve 10 sağlıklı gönüllü bu çalışmaya dahil edildi. Hastalardan 22'si Li, 10'u KZ kullanmaktaydı. Bütün deneklere 1 hafta boyunca proteinden kısıtlı diyet uygulandı. Proteinden kısıtlı diyet öncesi ve sonrası plazma 5-HT ve serbest L-triptofan (L-TRF) düzeyleri ölçüldü. Diyet sonrası semptomlar yeniden değerlendirildi. Bulgular: Diyet sonrası plazma 5-HT düzeyinin Li grubunda kontrol grubuna göre önemli oranda azalmış olduğu bulundu. Hastaların mizaçlarında önemli bir değişme tespit edilmedi. Tartışma: Li ya da KZ tedavisi ile ötimik olan bipolar I hastalarda protein kısıtlamasının sebep olduğu 5-HT işlevindeki bozulma mizaç değişiklikleri oluşturmada yetersiz olabilir.

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Cite This Article

TURAN, M. T., ÖZCAN, Y., EŞEL, E., KARAKÜÇÜK, İ., BAŞTÜRK, M. (2002). The effects of protein depletion on mood and plasma serotonin level in euthymic bipolar I patients treated with lithium or carbamazepine. Anadolu Psikiyatri Dergisi, Cilt: 3 - Sayı: 4, 206–211. https://ajindex.com/articles/356087

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