Might BPA and phthalates have a role in etiopathogenesis of ADHD?

Objective & Hypothesis:Objective: Although the etiology ofattention deficit hyperactivity disorder (ADHD) is unknown, it is thought that endocrine disruptors may be involved in the etiopathogenesis.

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Key Findings & Data:The aim of this study was to investigate the relationship between ADHD development and exposure to mono-(2-ethylhexyl) phthalate (MEHP), di-(2-ethylhexyl) phthalate (DEHP), and bisphenol A (BPA).

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Conclusion & Impact:However, further studies are needed to clarify the linkage between ADHD and endocrine disruptors.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: Although the etiology ofattention deficit hyperactivity disorder (ADHD) is unknown, it is thought that endocrine disruptors may be involved in the etiopathogenesis. The aim of this study was to investigate the relationship between ADHD development and exposure to mono-(2-ethylhexyl) phthalate (MEHP), di-(2-ethylhexyl) phthalate (DEHP), and bisphenol A (BPA). Methods: The study included 44 children who were diagnosed with ADHD according to DSM IV-TR diagnostic criteria and 51 healthy children as controls. In all subjects, serum MEHP, DEHP, and BPA were measured by using high performance liquid chromatography (HPLC). Results: Serum MEHP and BPA levels were found to be significantly higher in the ADHD group (0.47±0.22 µg/ml, 1.48±0.28 ng/ml) than the controls (0.31±0.13 µg/ml, 0.91±0.23 ng/ml). There was no difference in the level of DEHP between the ADHD group and healthy controls (2.17±0.69 µg/ml, 2.26±0.56 µg/ml). Conclusion: Our results could be accepted as an evidence to support an association between BPA, MEHPlevels and ADHD. However, further studies are needed to clarify the linkage between ADHD and endocrine disruptors.

Özet

Amaç: Dikkat eksikliği hiperaktivite bozukluğunun (DEHB) etiyolojisi tam olarak bilinmemekle birlikte, etiyopatogenezinde endokrin bozucuların rol oynadığı düşünülmektedir. Bu çalışmanın amacı, ADHD gelişimi ile mono- (2etilheksil) fitalat (MEHP), di- (2-etilheksil) fitalat (DEHP) ve bisfenol A'ya (BPA) maruz kalma arasındaki ilişkiyi araştırmaktır. Yöntem: Çalışmaya, DSM-IV-TR tanı ölçütlerine göre DEHB tanısı konan 44 çocuk ve kontrol grubu olarak 51 sağlıklı çocuk alındı. Tüm olgularda, serum MEHP, DEHP ve BPA, yüksek performanslı sıvı kromatografisi (HPLC) kullanılarak ölçüldü. Bulgular: Serum MEHP ve BPA düzeyleri DEHB grubunda (0.474±0.223 µg/ml, 1.485±0.285 ng/ml) kontrole (0.311±0.134 µg/ml, 906±0.232 ng/ml) göre istatistiksel olarak anlamlı yüksek bulundu. DEHP düzeyleri açısından her iki grup karşılaştırıldığında aralarında anlamlı fark bulunmadı (2.168±0.694 µg/ml, 2.262±0.565 µg/ml). Sonuç: Çalışmamızın sonuçları MEHP ve BPA düzeyleri ile DEHB arasındaki ilişki olduğunu destekler nitelikte kabul edilebilir. Bununla birlikte, DEHB ve endokrin bozucular arasındaki bağlantıyı açıklığa kavuşturmak için daha ileri çalışmalara gerek vardır.

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Cite This Article

ÖZTOP, D. B., DEMİRCİ, E., ÖZMEN, S., KONDOLOT, M., KARDAŞ, F., PER, H. (2018). Might BPA and phthalates have a role in etiopathogenesis of ADHD?. Anadolu Psikiyatri Dergisi, Cilt: 19 - Sayı: 3, 300–306. https://ajindex.com/articles/355735

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References (15)

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth ed., Text Revision, Washington DC, APA, 2000
Akinbami LJ, Liu X, Pastor PN, Reuben CA. Attention Deficit Hyperactivity Disorder Among Children Aged 5-17 Years in the United States, 1998-2009. NCHS Data Brief, 2011, p.1-8
Barkley RA. Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. New York: Guilford Press, 2006
Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol 2013; 42:132-155
Frederiksen H, Skakkebaek NE, Andersson AM. Metabolism of phthalates in humans. Mol Nutr Food Res 2007; 51:899-911
Won EK, Kim Y, Ha M, Burm E, Kim YS, Lim H, et al. Association of current phthalate exposure with neurobehavioral development in a national sample. Int J Hyg Environ Health 2016; 219:364-371
Li L, Zhang T, Qin XS, Ge W, Ma HG, Sun LL, et al. Exposure to diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes. Mol Biol Rep 2014; 41:1227-1235
Palanza P, Gioiosa L, vom Saal FS, Parmigiani S. Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environ Res 2008; 108:150-157
Braun JM, Kalkbrenner AM, Calafat AM, Yolton K, Ye X, Dietrich KN, et al. Impact of early life Bisphenol A exposure on behavior and executive function in children. Pediatrics 2011; 128:873- 882
Mortamais M, Pujol J, van Drooge BL, Macià D, Martínez-Vilavella G, Reynes C, et al. Effect of exposure to polycyclic aromatic hydrocarbons on basal ganglia and attention-deficit hyperactivity disorder symptoms in primary school children. Environ Int 2017; 105:12-19
Adesman A, Soled D, Rosen L. Formula feeding as a risk factor for attention-deficit/hyperactivity disorder: is bisphenol a exposure a smoking gun? J Dev Behav Pediatr 2017; 38(Suppl.7):545-551
Krause J. SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother 2008; 8:611-625
Kardas F, Bayram AK, Demirci E, Akin L, Ozmen S, Kendirci M, et al. Increased serum phthalates (MEHP, DEHP) and bisphenol A concentrations in children with autism spectrum disorder: The role of endocrine disruptors in autism etiopathogenesis. J Child Neurol 2015; 19:142-143
Van Neerven S, Kampmann E,Mey J. RAR/RXR and PPAR/RXR signaling in neurological and psychiatric diseases. Prog Neurobiol 2008; 85:433-451
Tanida T, W