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Journals / Anadolu Psikiyatri Dergisi / 2019 / Cilt: 20 - Sayı: 6

Predictors of drug treatment resistance in obsessive compulsive disorder

Obsesif kompulsif bozuklukta ilaç tedavisine direncin yordayıcıları

Esra Ünverdi BIÇAKCI
Hatice ÖZYILDIZ GÜZ
Ahmet Rifat ŞAHİN
Ömer BÖKE
Gökhan SARISOY
AYTÜL KARABEKİROĞLU
Pages
565–572
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The high severity of the disease and the presence of psychiatric dis- eases in the family increase the risk of treatment resistance. (Anatolian Journal of Psychiatry 2019; 20(6):565- 572)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study is to investigate the predictive factors related to pharmacotherapy resistance in patients with obsessive-compulsive disorder (OCD).
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Key Findings & Data:Methods: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Structured Clinical Interview for DSM-III-R Axis II Disorders (SCID-II), Yale-Brown Obsessive Compulsive Scale-Symptoms Checklist (YBOCS), Hamilton Depression Rating Scale (HDRS), Childhood Trauma Questionnaire (CTQ), Dissociative Experiences Scale, Level of Expressed Emotion were applied to 30 treatment resistant patient with OCD and 30 treatment responder patients with OCD.
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Conclusion & Impact:Conclusion: The high severity of the disease and the presence of psychiatric dis- eases in the family increase the risk of treatment resistance. (Anatolian Journal of Psychiatry 2019; 20(6):565- 572)
🔬Design:Survey & Empirical Study
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to investigate the predictive factors related to pharmacotherapy resistance in patients with obsessive-compulsive disorder (OCD). Methods: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Structured Clinical Interview for DSM-III-R Axis II Disorders (SCID-II), Yale-Brown Obsessive Compulsive Scale-Symptoms Checklist (YBOCS), Hamilton Depression Rating Scale (HDRS), Childhood Trauma Questionnaire (CTQ), Dissociative Experiences Scale, Level of Expressed Emotion were applied to 30 treatment resistant patient with OCD and 30 treatment responder patients with OCD. Expressed Emotion Scale (EES) were applied to the relatives of patients. Results: When the groups were compared, living out of city center, age of onset in disease, total disease duration and presence of psychiatric disease in the family, YBOCS, HDRS, OVIS, EES, CTQ sexual abuse scale scores and major depression comorbidity were significantly higher in treatment resistant group. High YBOCS total score and presence of mental illness in the family were found to be effective for predicting resistance to drug treatment. Conclusion: The high severity of the disease and the presence of psychiatric dis- eases in the family increase the risk of treatment resistance. (Anatolian Journal of Psychiatry 2019; 20(6):565- 572)

Özet

Amaç: Bu çalışmanın amacı, obsesif kompulsif bozukluk (OKB) hastalarında ilaç tedavisine direnci yordayıcı etken-leri araştırmaktır. Yöntem: Tedaviye dirençli 30 hasta ile tedaviye dirençli olmayan 30 hastaya DSM-IV Eksen IBozuklukları için Yapılandırılmış Klinik Görüşme (SCID-I), DSM-III-R Eksen II Bozuklukları için Yapılandırılmış KlinikGörüşme (SCID-II), Yale-Brown Obsesyon Kompulsiyon Ölçeği-Belirti Kontrol Listesi (YBOKÖ), Hamilton Depres-yon Derecelendirme Ölçeği (HDDÖ), Aşırı Değer Verilmiş Düşünce Ölçeği (ADDÖ), Çocukluk Çağı TravmalarıÖlçeği (ÇÇTÖ), Dissosiyatif Yaşantılar Ölçeği ve Duygu Dışavurum Düzeyi Ölçeği; hasta yakınlarına ise DuyguDışavurum Ölçeği (DDÖ) uygulandı. Bulgular: Gruplar karşılaştırıldığında il merkezi dışında yaşama, hastalığınbaşlama yaşı, toplam hastalık süresi ve ailede psikiyatrik bozukluk, YBOKÖ, HDDÖ, ADDÖ, DDÖ, ÇÇTÖ cinselistismar ölçek puanları, majör depresyon eş tanısı dirençli grupta anlamlı düzeyde yüksekti. Yüksek YBOKÖ toplampuanının ve ailede psikiyatrik bozukluk varlığının ilaç tedavisine direnci yordamada etkili olduğu belirlendi. Sonuç:Hastalık şiddetinin fazla olması ve ailede psikiyatrik bozukluk varlığı tedaviye direnç riskini artırmaktadır. (AnadoluPsikiyatri Derg 2019; 20(6):565-572)

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Cite This Article

BIÇAKCI, E. Ü., GÜZ, H. Ö., ŞAHİN, A. R., BÖKE, Ö., SARISOY, G., KARABEKİROĞLU, A. (2019). Predictors of drug treatment resistance in obsessive compulsive disorder. Anadolu Psikiyatri Dergisi, Cilt: 20 - Sayı: 6, 565–572. https://ajindex.com/articles/355725

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References (13)

  1. Sadock BJ. Sadock VA. Kaplan & Sadock's Comprehensive Textbook of Psychiatry. H Aydın, A Bozkurt (Çev.), İstanbul: Güneş Kitabevi, 2007, s.1718-1788. Tükel R. Demet MM. Obsesif-kompulsif bozukluğun farmakoterapisi. Tükel R, Alkın T (Ed.), Anksiyete Bozuklukları, Ankara: Türki-ye Psikiyatri Derneği Yayınları, 2006, s.339-361.
  2. Rasmussen SA, Eisen JL, Pato MT. Current issues in the pharmacologic management of obsessive compulsive disorder. J Clin Psychiatry 1993; 54:4-9.
  3. Jenike MA, Rauch SL. Managing the patient with treatment-resistant obsessive compulsive disor- der: current strategies. J Clin Psychiatry 1994; 55:11-17.
  4. Matsunaga H, Kiriike N, Matsui T, Miyata A, Iwasaki Y, Fujimoto K, et al. Gender differences in social and interpersonal features and personality disorders among Japanese patients with obses- sive compulsive disorder. Compr Psychiatry 2000; 41:266-272.
  5. Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, et al. Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry 2001; 158(11):1899-903.
  6. Kutaniş R, Özer ÖA, Eryonucu BT. Obsesif kompulsif bozuklukta sosyodemografik verilerin tedaviye direnç açısından karşılaştırılması. Tıp Araştırmaları Dergisi 2003; 1:15-20.
  7. Hibbs ED, Hamburger SD, Lenane M, Rapoport JL, Kruesi MJP, Keysor CS, et al. Determinants of expressed emotion in families of disturbed and normal children. J Child Psychol Psychiatry 1991; 32:757-770.
  8. Chambless DL, Steketee G. Expressed emotion and behavior therapy outcome: A prospective study with obsessive–compulsive and agora- phobic outpatients. J Consult Clin Psychol 1999; 67:658-666.
  9. Chambless DL, Floyd FJ, Rodebaugh TL, Steketee GS. Expressed emotion and familial interaction: A study with agoraphobic and obses- sive-compulsive patients and their relatives. J Abnorm Psychol 2007; 116:754-761.
  10. Baer L, Jenike MA, Black DW, Treece C, Rosen- feld R, Greist J. Effect of axis II diagnoses on treatment outcome with clomipramine in 55 pa- tients with obsessive-compulsive disorder. Arch Gen Psychiatry 1992; 49:862-866.
  11. Hantouche EG, Demonfaucon C. Resistant obsessive compulsive disorder (ROC): Clinical picture, predictive factors and influence of affec- tive temperaments. Encephale 2008; 34:611-617.
  12. Erzegovesi S, Cavallini MC, Cavedini P, Diaferia G, Locatelli M, Bellodi L. Clinical predictors of drug response in obsessive-compulsive disorder. J Clin Psychopharmacol 2001; 21:488-492.
  13. Pallanti S, Grassi G, Cantisani A. Approaches to Treatment Resistan