Journals / Anestezi Dergisi / 2004 / Cilt: 12 - Sayı: 1

Delayed neuropathy due to organophosphate intoxication: Case report

Organofosfat zehirlenmesine bağlı gelişen gecikmiş nöropati (olgu sunumu)

Pages
73–76
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Polyneuropathy symptoms revealedfull recovery on the upper extremities and small recovery on the lower extremities at the end of the 4th month. in conclusion, organophosphate induced delayed polyneuropathy is an important cause of morbidity and is not a well known clinical presentation as acute toxicity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Organophosphorus compound intoxication is common in our country.
📊
Key Findings & Data:This neuropathy results in damage ofboth peripheral and central nervous systems. in this case report, a 56 year-old woman attempted silicide by taking approximately 950 mg $kg^-1$ dimethyl-2,2-dichloro vinyl phosphate (DDVP)(dichlorvos) oralfy.
💡
Conclusion & Impact:Polyneuropathy symptoms revealedfull recovery on the upper extremities and small recovery on the lower extremities at the end of the 4th month. in conclusion, organophosphate induced delayed polyneuropathy is an important cause of morbidity and is not a well known clinical presentation as acute toxicity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Polinöropatiler · Diklorvos · Zehirlenme

Abstract

Organophosphorus compound intoxication is common in our country. Some patients subsequently have organophosphate-induced delayed neuropathy. This neuropathy results in damage ofboth peripheral and central nervous systems. in this case report, a 56 year-old woman attempted silicide by taking approximately 950 mg $kg^-1$ dimethyl-2,2-dichloro vinyl phosphate (DDVP)(dichlorvos) oralfy. After a muscarinic and cholinergic syndrome lasting three days, she developed a purely motor distal axonal polyneuropathy on the 16th day. Polyneuropathy symptoms revealedfull recovery on the upper extremities and small recovery on the lower extremities at the end of the 4th month. in conclusion, organophosphate induced delayed polyneuropathy is an important cause of morbidity and is not a well known clinical presentation as acute toxicity.

Özet

Organofosfat içeren bileşiklere bağlı zehirlenmeler ülkemizde oldukça sık gözlenir. Bu olguların bazılarında organofosfata bağlı gecikmiş nöropati gelişebilir. Bu nöropati hem periferik hem santral sinir sisteminin her ikisinde de hasar ile sonuçlanır. Bu sunumdaki 56 yaşındaki kadın hasta intihar amacı ile insektisit olarak kullanılan yaklaşık 950 mg $kg^-1$ dimetil-2,2-dikloro vinil fosfatı (DDVP)(diklorvos) oral olarak almıştır. Üçüncü güne kadar muskarinik ve kolinerjik belirtiler süren olguda, 16. günde motor distal aksonal nöropati gelişti. Polinöropati semptomları 4. ayın sonunda üst ekstremitelerde tamamen alt ekstremitelerde büyük oranda geriledi. Sonuç olarak organofosfata bağlı gecikmiş tip nöropati, önemli bir morbidite sebebidir ve akut toksisitenin kliniği kadar klinik seyri iyi bilinmemektedir.

🔖

Cite This Article

ÇELİK, J., AYSOLMAZ, G., ÖKESLİ, S. (2004). Delayed neuropathy due to organophosphate intoxication: Case report. Anestezi Dergisi, Cilt: 12 - Sayı: 1, 73–76. https://ajindex.com/articles/355594

References (15)

  1. John M, Gömmen A, Zachariah A. Muscle injury in organophosp-horus poisoning and its role in the development of intermediate syndrome. Neur Toxicol 2003;24:43-53
  2. Genel F, Arslanoğlu S, Uran N, Doğan M, Atlıhan F. Late-onset distal polyneuropathy due to acute organophosphate intoxication case repon. Turkish J Pediatr 2003;45:67-70
  3. Anadol D, Çamur S, Öztürk R. Korkmaz A, Özalp İ. A statistical study of 286 cases admitted to the Pediatric Intensive Care Unit: a one year experience, 2nd World Congress on Pediatric Intensive Care, 23-26 June 1996, Rotterdam, The Netherlands
  4. Pınar A, Fowler J, Bond GR. Acute poisoning in izmir. Turkey-a pilot epidemiologic study. i Toxicol Clin Toxicol 1993; 31: 593-601
  5. Hallaç İK, Poyrazoğlu MH, Aydın K, Kurtoğlu S, Üstünbaş S, Üstünbaş HB. Çocukluk çağı zehirlenmeleri: son 10 yılın değerlendirilmesi. İstanbul Çocuk Kliniği Dergisi 1996; 31: 337-9
  6. Chia-Chang Chuang, Lin TS, Tsai MC. Delayed neuropathy and myelopathy after organophosphate intoxication. N EngI J Med 2002; 347:1119-21
  7. Abou-Donia MB, Lapadula DM. Mechanisms of organophosphorus ester-induced delayed neurotoxicity: type I and type II. Ann Rev Pharmacol Toxicol 1990; 30: 405-40
  8. Cherniak MG. Organophosphorus esters and polyneuropathy. Ann Intern Med 1986;104: 264-6
  9. Davis CS, Richardson RJ. Organophosphorus compounds. in: Spencer S and Schaumburg H.H, Editors, Experimental and Clinical Neurotoxicology, Williams and Wilkins, Baltimore (1980), pp.527-44
  10. Oliveira GH, Moreira V, Goes SPR. Organophosphate induced delayed neuropathy in genetically dissimilar chickens: studies with tri-ortho-cresyl phosphate (TOCP)and trichlorfon. Toxicology Letters. 2002; 136: 143-50
  11. Vasconcellos LFR, Leite AC, Nascimento OJM. Organophosphate-induced delayed neuropathy. Arq Neuro-Psiquatr 2002;60:126-30
  12. Sigolaeva LV, Eremenko AV, Makover A, Makhaeva GF, Malygin VV, Kurochkin LN. A new approach for determination of neuropathy target esterase activity. Chem - Biol Inter 1999; 119-120: 559-65
  13. Johnson MK, The target for initiation of delayed neurotoxicity by organophosphorus esters: biochemical studies and toxicological applications. In: Hodgson E, Bend JR, Philpot RM, Editors, Reviews in Biochemical Toxicology 4, Elsevier, Amsterdam (1982), pp. 221-30
  14. Weiner ML, Jorüıer BS. Organophosphate induced delayed neurotoxicity of triarylphosphates. Neurotoxicology 1999; 20: 653-73
  15. Lotti M. Becker CE, Aminoff MS. Organophosphate polyneuropa