Journals / Anestezi Dergisi / 2004 / Cilt: 12 - Sayı: 3

The efficacy of remifentanil combined with either propofol, sevoflurane or desflurane during controlled hypotension

Kontrollü hipotansiyonda remifentanil ile birlikte uygulanan propofol, desfluran ve sevofluranın etkinliği

Pages
191–196
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We concluded that since all three anesthetic techniques provided hemodynamic stability and good visualization of the surgical field, they may be used for controlled hypotension management.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to compare the effects of a combination of remifentanil with propofol, desflurane or sevoflurane on intraoperative controlled hypotension, quality of the surgical field and recovery characteristics in patients undergoing nose surgery.
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Key Findings & Data:ASA physical status 1,18-47 yr of age, 54 patients were randomly divided to three groups and received remifentanil l$mu$g $kg^{-1}$ as a bolus dose followed by a continuous infusion of 0.25 $mu$g $kg^{-1}$ $min^{-1}$.
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Conclusion & Impact:We concluded that since all three anesthetic techniques provided hemodynamic stability and good visualization of the surgical field, they may be used for controlled hypotension management.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anestezikler · inhalasyon · Anestezikler

Abstract

The aim of this study was to compare the effects of a combination of remifentanil with propofol, desflurane or sevoflurane on intraoperative controlled hypotension, quality of the surgical field and recovery characteristics in patients undergoing nose surgery. ASA physical status 1,18-47 yr of age, 54 patients were randomly divided to three groups and received remifentanil l$mu$g $kg^{-1}$ as a bolus dose followed by a continuous infusion of 0.25 $mu$g $kg^{-1}$ $min^{-1}$. In propofol group, anesthesia was induced 1.5-2 mg $kg^{-1}$ of propofol and maintained with a continuous infusion of 100-200 $mu$g $kg^{-1}$ $min^{-1}$. In sevoflurane group, anesthesia was induced with 7% sevoflurane in 100% oxygen, and was maintained with 1-2% sevoflurane and air in oxygen. In desflurane group, anesthesia was induced 1.5-2 mg kg'1 of propofol and maintained with 4-6% desflurane and air in oxygen. The study drug titration was adjusted to keep the systolic blood pressure (SBP) between 80-100 mmHg during surgery. During controlled hypotension, while SBP was significantly lower in desflurane and sevoflurane groups than in propofol group, mean blood pressure (MBP) was significantly lower in sevoflurane group than in other groups (p<0.05). Supplemental hypotensive agent was administered to 2 patients in propofol group and 1 patient in desflurane group. After extubation, MBP and heart rate (HR) significantly increased in propofol group, HR significantly increased in sevoflurane group, SBP, MBP and HR significantly increased in desflurane group according to preinduction values (p<0.05)Estimated blood loss and surgical field score was similar in all three groups. The time to extubation and early recovery was significantly shorter in desflurane group than in sevoflurane and propofol groups (p<0.05). We concluded that since all three anesthetic techniques provided hemodynamic stability and good visualization of the surgical field, they may be used for controlled hypotension management. However, sevoflurane-remifentanil combination may be preferable, because it did not cause any increase in blood pressure after extubation.

Özet

Bu çalışmada, septoplasti veya septorinoplasti geçirecek olgularda, remifentanil ile birlikte uygulanan propofol, desfluran ve sevofluranın intraoperatif kontrollü hipotansiyon sağlanması, cerrahi alan kalitesi ve derlenme üzerine olan etkilerinin karşılaştırılması amaçlandı. ASA I grubu, 18-47 yaş arası 54 olgu rasgele üç gruba ayrılarak, l$mu$g $kg^{-1}$ bolus doz sonrası 0.25 $mu$g $kg^{-1}$ $dk^{-1}$ remifentanil infüzyonuna başlandı. Propofol grubuna, l.5-2 mg $kg^{-1}$ propofol ve sonrasında 100-200 $mu$g $kg^{-1}$ $dk^{-1}$ propofol infüzyonu; sevofluran grubuna %7 sevofluran %100 O2 ile indüksiyon sonrası %l-2 sevofluran ve hava-02 karışımı; desfluran grubuna propofol 1.5-2 mg $kg^{-1}$ verildikten sonra %4-6 desfluran ve hava-O2 karışımı uygulandı. Cerrahi süresince sistolik arter basıncını (SAB) 80-100 mmHg arasında tutacak şekilde ilaç dozları ayarlandı. Kontrollü hipotansiyon döneminde SAB, desfluran ve sevofluran grubunda propofol grubuna göre, ortalama arter basıncı (OAB) sevofluran grubunda diğer gruplara göre anlamlı düşüktü (p<0.05). Propofol grubunda 2, desfluran grubunda l olguda ek hipotansif ajan uygulandı. Ekstübasyon sonrasında, propofol grubunda OAB ve kalp atım hızı (KAH), sevofluran grubunda KAH, desfluran grubunda ise SAB, OAB ve KAH indüksiyon öncesi değerlere göre anlamlı yükseldi (p<0.05). Kanama miktarı ve cerrahi alan skoru her üç grupta benzerdi. Ekstübasyon ve erken derlenme zamanı desfluran grubunda propofol ve sevofluran grubuna göre daha kısaydı (p<0.05). Sonuç olarak; kontrollü hipotansiyon uygulamasında üç anestezik tekniğin de stabil hemodinami ve iyi cerrahi görüş alanı sağlaması nedeniyle kullanılabileceği kanısındayız. Ancak, ekstübasyon sonrası kan basıncı artışı görülmemesi nedeniyle sevofluran-remifentanil kombinasyonu tercih edilebilir.

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Cite This Article

DEMİRBİLEK, S., GÜLHAŞ, N., ÖZTÜRK, E., BUT, A. K., ASLAN, Ü., ERSOY, M. Ö. (2004). The efficacy of remifentanil combined with either propofol, sevoflurane or desflurane during controlled hypotension. Anestezi Dergisi, Cilt: 12 - Sayı: 3, 191–196. https://ajindex.com/articles/355480

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