Journals / Anestezi Dergisi / 2000 / Cilt: 8 - Sayı: 2

The hemodynamic and blood gas effects of carbondioxide and nitrous oxide pneumoperitoneum in dogs

Karbondioksit ve azotprotoksit pnömoperitonyumunun hemodinamik ve kan gazı etkilerinin yavru köpek modelinde araştırılması

Pages
99–104
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is concluded that N<sub>2</sub>O may be an alternative to CO<sub>2</sub> for children that are at risk for hypercarbia.

📌 3 Key Takeaways

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Objective & Hypothesis:The effects of carbon dioxide (CO<sub>2</sub>) and nitrous oxide (N<sub>2</sub>O) pneumoperitoneum on hemodynamics and blood gases in children were studied using a puppy model.
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Key Findings & Data:After premedication with xylazine, 22 dogs were anesthetized with 30 mg.kg-<sup>-1</sup> i.m. ketamine and femoral artery andsaphenous veins were canulated.
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Conclusion & Impact:It is concluded that N<sub>2</sub>O may be an alternative to CO<sub>2</sub> for children that are at risk for hypercarbia.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Ksilazin · Kan gazı analizi · Nitröz oksit

Abstract

The effects of carbon dioxide (CO<sub>2</sub>) and nitrous oxide (N<sub>2</sub>O) pneumoperitoneum on hemodynamics and blood gases in children were studied using a puppy model. After premedication with xylazine, 22 dogs were anesthetized with 30 mg.kg-<sup>-1</sup> i.m. ketamine and femoral artery andsaphenous veins were canulated. Insufflation was conducted with a pressure of 10-12 mmHg of CO<sub>2</sub> in group I (n=II) and N<sub>2</sub>O in group II (n=II). Heart rate (HR), sysiolics (SAP) diastolic (DAP) and mean (MAP) arterial pressures, blood gases (PaO<sub>2</sub>, PaCO<sub>2</sub>); end tidal carbon dioxide (ETCO<sub>2</sub>) and N<sub>2</sub>O % during expirium were recorded before insufflation (control), 15 minutes after insufflation (AI) and 15 minutes after desufflation (AD). Variance analysis for repeated measures were used for statistics, p<0.05 was considered as significant. HR, SAP, DAP, MAP, ETCO<sub>2</sub> and PaCO<sub>2</sub> increased AI in Group I. SAP decreased AI and DAP increased AD in Group II. MAP AI was higher in Group I,. PaCO<sub>2</sub> and ETCO<sub>2</sub> were higher in Group I, AI and AD. In Group II, N2O was not recorded in expired air. It is concluded that N<sub>2</sub>O may be an alternative to CO<sub>2</sub> for children that are at risk for hypercarbia.

Özet

Laparoskopi amacıyla oluşturulan pnömoperitonyum için kullanılan karbondioksit (CO 2 ) ve azot protoksitin (N 2 O) çocuklarda hemodinamiye ve kan gazlarına etkileri yavru köpek modeli kullanılarak araştırıldı. Köpekler (n=22) xylazin ile premedike edilip, ketamin 30 mg.kg -1 (im) ile anestetiğe edildikten sonra, femoral arter ve safen venine kanüller yerleştirildi. Grup I'e (n=II) intraperitoneal olarak 10-12 mmHg basınçla CO 2 , grup H'ye (n=II) N 2 O verildi. Kalp atım hızları (KAH), sistolik (SAB), diyastolik (DAB) ve ortalama (OAB) arter basınçları, kan gazlan (PaO 2 , PaCO 2 ), solunum havasındaki end tidal karbon dioksit (ETCO 2 ) ve %N 2 O değerleri işlem öncesi (kontrol) insuflasyon sonrası (İS) 15. dakika ve desuflasyon sonrası (DS) 15. dakikalarda kaydedildi. İstatistiksel değerlendirmede tekrarlayan ölçümlerde varyans analizi kullanıldı, p 2 ve PaCO 2 İS'da kontrole göre arttı. Grup II'de kontrole göre SAB, İS'da azalıp, DAB, DS'da arttı. Her iki grup arasında OAB İS zamanında, ETCO 2 ise İS ve DS zamanlarında anlamlı farklılık gösterdi. N 2 O insuflasyonu yapılan Grup II'de ekspiriyum havasında N 2 O saptanmadı. Sonuçta; N 2 O ile pnömoperitonyumun hiperkarbinin riskli olduğu çocuklarda CO 2 'e alternatif olabileceği kanısına varıldı.

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Cite This Article

DUMAN, A., YOSUNKAYA, A., ÖĞÜN, Ö. C., ABASIYANIK, A., DAŞCI, Z. (2000). The hemodynamic and blood gas effects of carbondioxide and nitrous oxide pneumoperitoneum in dogs. Anestezi Dergisi, Cilt: 8 - Sayı: 2, 99–104. https://ajindex.com/articles/355363

References (17)

  1. Holocomb GW, Olsen DO, Sharp KW. Laparascopie cholecy-stectomy in the pediatric patient. J Pediatr Surg 1991
  2. 90, 2. Moir CR, Donohue JH, van Heerden JA, Laparoscopic cholecy-steetomy in children: Initial experience and recomendations. J Pediatr Surg 1992
  3. Miller SS. Laparoscopic operations in pediatric surgery. Br J Surg 1992
  4. Mc Mahon AJ, Baxter JN, Murray W, Imrie CW. Kenny G, O'Dwyer PJO. Helium pneumnoperitoneum for laparoseopic cholecystectomy: Ventilatory and blood gas changes. Br J Surg 1994
  5. Rademaker BM, Odoom JA, de Wit LT, Kalkman CJ, ten Brink SA, Ringers J. Haemodynamic effects of pneumoperitoneura for laparoskopic surgery
  6. a comparison of CO2 with N2O insufflation. Euro J Anaesth 1994
  7. Oaka T, Kawano Y, Kosaka Y, Tanaka A. Blood gas changes during laparoscopic cholecystectomy-comparative study of N2O pneumoperitoneum and CO2 pneurnoperitoneum. Masui 1993
  8. El-Miawi MF, Wahabi O, El Bagouri IS, et al. Physiologic changes during CO2 and N2O pneumoperitoneum in diagnostic laparoscopy. J Repro Med 1981
  9. Graham AJ, Jirch DW, Barrington KJ, Hayashi AH. Effect of intraabdominal CO22 insufflation in the piglet. J Pediatr Surg 1994
  10. Marshall RL, Jepson PRJ, Davie IT, Scott B. Circulatory effects of peritoneal insufflation with nitrous oxide. Br J Anaesth 1972
  11. Ho HS, Gunther RA, Wolfe BM. Intraperitoneal carbon dioxide insufflation and cardiopulmonary functions. Laparoscopie choleeystectomy in pigs. Arch Surg 1992
  12. Yavru N. Deney hayvanları. Konya, Selçuk Üniversitesi Yayınevi 1996
  13. Sackier JM. Laparoscopy in pediatric surgery. J Pediatr Surg 1991
  14. Weldschmidt i, Schler F. Laparoscopic surgery in neonates and infants. Eur J Pediatr Surg 1991
  15. Shuto K, Kitano T, Yobhida T, et al. Hemodynamic and arterial blood gas changes during carbon dioxide and helium pneumoperitoneum in pigs. Surg Endosc 1995
  16. Bevan DR. Acid-base balance in relation to anaesthesia. In: Nunn JF, Utting JE. Brown BR, (eds) General Anaesthesia, London, Butterworths 1989: 294-309. 16. Odberg S, Ljungvist O, Svenberg T, Sollevi A. Lack of neuro-humoral response to pneumoperitoneum for laparoseopic cholecystectomy. Surg Endosc 1998
  17. Luz CM, Polarz H. Bohrer H, Hundt G, Dorsam J. Martin E. Hemodynamic and respiratory effects of pneumoperitoneum and PEEP during laparoseopic