Journals / Anestezi Dergisi / 2002 / Cilt: 10 - Sayı: 4

Anesthesia for living-donor liver transplantation: Comparison of 20 adult and 10 pediatric patients

Canlı donörden karaciğer transplantasyonu anestezisi sonuçları: 20 yetişkin 10 pediyatrik hastanın karşılaştırılması

Pages
277–284
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion, immediate replacement therapies according to the laboratory and hemodynamic measurement performed at certain appropriate operation period are important in maintaining a stable peroperative course in both patient groups.

📌 3 Key Takeaways

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Objective & Hypothesis:Twenty adult and ten pediatric patients undergoing Living-Donor Liver Transplantation were evaluated in terms of perioperative anesthetic courses.
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Key Findings & Data:Recipients had an anesthesia consisting of tiopental Na, fentanyl citrate/remifentanil oxygen/air with isoflurane or midazolam/propofol and vecuronium/cisatracurium.
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Conclusion & Impact:In conclusion, immediate replacement therapies according to the laboratory and hemodynamic measurement performed at certain appropriate operation period are important in maintaining a stable peroperative course in both patient groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Geriyedönük çalışma · Karaciğer nakli · Anestezikler

Abstract

Twenty adult and ten pediatric patients undergoing Living-Donor Liver Transplantation were evaluated in terms of perioperative anesthetic courses. Recipients had an anesthesia consisting of tiopental Na, fentanyl citrate/remifentanil oxygen/air with isoflurane or midazolam/propofol and vecuronium/cisatracurium. The duration of the anesthesia and anhepatic periods of the pediatric patients were shorter compared to the adult group (541±106 vs 649±149 minutes and 47±12 vs 89±54 minutes, p<0.05). During the anhepatic periods of the operations cardiac output decreased 30% in adults vs 14% in pediatric patients (p>0.05), while a 38% increase in SVR values of adult cases and 74% increase in pediatric cases was observed (p<0.05). Postreperfusion syndromes were seen in two pediatric (20%) and five (25%) adult patients necessitating ephedrine boluses. Perioperative blood and fresh frozen plasma needs of the adult and pediatric groups were similar (Blood, 0.10±0.08 vs 0.11± 0.07 U kg-1; TDP, 0.11±0.07 vs 0.12±0.07 U kg-1, respectively p>0.05). Calcium gluconate requirement in pediatric patients was greater than the adult group (1.20±1.23 vs 0.62±0.78 mEq kg-1, p<0.05). Survival rates of the two patient groups was 70% in adults vs 60% in pediatric patients. In conclusion, immediate replacement therapies according to the laboratory and hemodynamic measurement performed at certain appropriate operation period are important in maintaining a stable peroperative course in both patient groups. Pediatric cases of smaller ages can be managed without monitoring with a pulmonary artery catheter. Use of proper anesthetic agents and stable hemodynamics during the operations can lead to extubation of the selected patients in the operating room and earlier recovery.

Özet

Canlı donörden karaciğer transplantasyonu (CDKT) geçiren 20 yetişkin ve 10 pediyatrik hasta perioperatif anestezi özellikleri açısından retrospektif olarak karşılaştırıldı. Alıcıların anestezisi, tiyopental sodyum, fentanil sitrat/remifentanil, oksijen/hava içerisinde isofluran veya midazolam/propofol ve vekuronyum/ sisatrakuryum'dan oluşturulmuş kombinasyonlar ile sağlandı. Pediyatrik grubun anestezi süresi ve ameliyatlarının anhepatik dönem süresi yetişkin gruba göre daha kısa idi (541±106 ve 649±149 dakika ile 47±12 ve 89±54 dakika, p 0.05), sistemik vasküler rezistansta yetişkinlerde %38, pediyatrik hastalarda %74 artma izlendi (p 0.05) bulundu; pediyatrik grubun kalsiyum glukonat replasmanı gereksinimi yetişkin gruba göre yüksek bulundu (1.20±1.23'e 0.62±0.78 mEq kg-1, p<0.05). ilk 30 hastanın yer aldığı bu çalışmadaki halen yaşayan hasta oranı yetişkin grupta %70, pediyatrik grupta %60'dır. Sonuç olarak, hem yetişkin hem de pediyatrik canlı donör karaciğer transplantasyonu ameliyatları için alıcı ve donör eş zamanlı anestezi uygulamasını gerektirmektedir. Her iki hasta grubu için, hemodinamik ve laboratuvar kontrollarının operasyon dönemlerinin özelliklerine uygun olarak ve replasman tedavilerinin zamanında yapılması perioperatif stabilitenin sağlanmasında önemli olmaktadır. Küçük yaştaki pediyatrik hastalar yetişkinlerden farklı olarak pulmoner arter kateteri yerleştirilmeden izlenebilmektedir. Anestezik ajanların uygun seçimi ve titrasyonu ile genellikle elektif olarak gerçekleştirilen bu operasyonların sonunda her iki yaş grubundan seçilen bazı hastaların operasyon salonunda ekstübasyonu ve derlenmesinin sağlanması mümkün olabilecektir.

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Cite This Article

AYANOĞLU, H. Ö., ULUKAYA, S., KOCABAŞ, N. S., ÇÖKMEZ, A. Z. (2002). Anesthesia for living-donor liver transplantation: Comparison of 20 adult and 10 pediatric patients. Anestezi Dergisi, Cilt: 10 - Sayı: 4, 277–284. https://ajindex.com/articles/355303

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