AI Summary & Key Takeaways
AI InsightWhen compared to normal weight patients, neuromuscular effects of cisatracurium detected to be short in duration in morbidly obese patients.
📌 3 Key Takeaways
Abstract
In this study, the neuromuscular effects of cisatracurium were compared between morbidly obese and normal weight patients. Morbidly obese patients are named morbidly obese group (n=20), and normal patients are named control group (n=20). In the morbidly obese group, corrected weight was used to calculate the drug doses. 0.15 mg kg-1 cisatracurium was administered. T0 (onset time), T25 (25 % recovery of T1), T25-75 (time of T25 to T75) time of according to TOF was recorded. Body mass index values were found to be 55±5 kg m-2, 22±4 kg m-2 in the morbidly obese and control groups, respectively. T0 was determined 177±23 s, 168±19 s in the morbidly obese, and control group, respectively. T25 was determined 46±7 min, 56±8 min, in the morbidly obese and control group, respectively (p<0.05). T25-75 was determined 11±5 min, 14±6 min in the morbidly obese and control group, respectively (p<0.05). In the morbidly obese group, intubation conditions were determined good in 13 patients, excellent in 7 patients, and it were good in 4, excellent in 16 in the control group (p<0.05). When compared to normal weight patients, neuromuscular effects of cisatracurium detected to be short in duration in morbidly obese patients.
Özet
Bu çalışmada normal ağırlıklı ve morbid obez olgularda cisatrakuryumun nöromusküler iletime etkileri karşılaştırıldı. Olgular morbid obez grubu (n=20) ve kontrol grubu (n=20) olarak ikiye ayrıldı. Morbid obez olgularda ilaç dozları düzeltilmiş ağırlığa göre verildi. Cisatrakuryum 0.15 mg kg-1 dozda verildi. TOF'a göre; T0 (etki başlama süresi), T25 (T1'in % 25 geri döndüğü zaman), T25-75 (T25'in T75'e ulaştığı zaman) kaydedildi. Vücut kitle indeksi morbid obez ve kontrol grubunda sırası ile 55 ±5 kg m-2, 22+4 kg m-2 olarak belirlendi. T0 zamanı morbid obez ve kontrol grubunda sırası ile 177±23 sn, 168 ±19 sn olarak belirlendi. T25 morbid obez ve kontrol grubunda sırası ile 46±7 dk, 56±8 dk olarak belirlendi (p<0.05). T25-75 morbid obez ve kontrol grubunda sırası ile 11±5 dk, 14±6 dk olarak belirlendi (p<0.05). Entübasyon kalitesi morbid obez grubunda 13 hastada iyi, 7 hastada mükemmel, kontrol grubunda 4 hastada iyi 16 hastada mükemmel olarak belirlendi (p<0.05). Normal ağırlıklı olgulardan farklı olarak, morbid obez olgularda cisatrakuryumun nöromusküler iletime etkisinin daha kısa süreli olduğu belirlendi.