SavedAdd your journal

Journals / art / 2017 / Cilt: 32 - Sayı: 4

Crosslinks Between Human Leukocyte Antigen DRB1*01 and Human Leukocyte Antigen DRB1*13 Allelic Variants and Occurrence of Rheumatoid Arthritis in Patients From Federation of Bosnia and Herzegovina

Amela SAHOVIC
Damir SULJEVIC
Elma FEJZİC
Andi ALİJAGİC
Journal
art
Pages
290–297
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This genotype variant may be considered a predisposing factor for the development of RA.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: This study aims to analyze human leukocyte antigen A (HLA-A), human leukocyte antigen B (HLA-B), human leukocyte antigen C (HLA-C), HLA-DRB1*, HLA-DRB3*, HLA-DRB4*, HLA-DRB5*, HLA-DQB1* loci expression in patients with rheumatoid arthritis (RA) in the Federation of Bosnia and Herzegovina.Patients and methods: Deoxyribonucleic acid was isolated from peripheral blood of 48 RA patients (22 males, 26 females; mean age 36 years; range 2 to 63 years) and 104 healthy control individuals (52 males, 52 females; mean age 43 years; range 2 to 76 years).
📊
Key Findings & Data:Deoxyribonucleic acid samples were analyzed using polymerase chain reaction-sequence-specific primers and sequence specific oligonucleotides methods.Results: The most frequent allelic groups in RA patients were HLA-DRB1*01 (odds ratio=2.795; 95% confidence interval: 1.441-5.421; p=0.004) and HLA-DRB1*04 (odds ratio=2.573; 95% confidence interval: 1.214-5.453; p=0.023).
💡
Conclusion & Impact:This genotype variant may be considered a predisposing factor for the development of RA.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to analyze human leukocyte antigen A (HLA-A), human leukocyte antigen B (HLA-B), human leukocyte antigen C (HLA-C), HLA-DRB1*, HLA-DRB3*, HLA-DRB4*, HLA-DRB5*, HLA-DQB1* loci expression in patients with rheumatoid arthritis (RA) in the Federation of Bosnia and Herzegovina.Patients and methods: Deoxyribonucleic acid was isolated from peripheral blood of 48 RA patients (22 males, 26 females; mean age 36 years; range 2 to 63 years) and 104 healthy control individuals (52 males, 52 females; mean age 43 years; range 2 to 76 years). Deoxyribonucleic acid samples were analyzed using polymerase chain reaction-sequence-specific primers and sequence specific oligonucleotides methods.Results: The most frequent allelic groups in RA patients were HLA-DRB1*01 (odds ratio=2.795; 95% confidence interval: 1.441-5.421; p=0.004) and HLA-DRB1*04 (odds ratio=2.573; 95% confidence interval: 1.214-5.453; p=0.023). Among RA patients, the most frequent genotype for the allelic group HLA-DRB1*, in the light of the common epitopes theory, was observed for DRB1*01/DRB1*13. This genotype indicates an increased incidence and relative risk (odds ratio=11.09).Conclusion: The most common genotype in our RA patients was DRB1*01/DRB1*13, which showed increased frequency and a high relative risk. This genotype variant may be considered a predisposing factor for the development of RA.

🔖

Cite This Article

SAHOVIC, A., SULJEVIC, D., FEJZİC, E., ALİJAGİC, A. (2017). Crosslinks Between Human Leukocyte Antigen DRB1*01 and Human Leukocyte Antigen DRB1*13 Allelic Variants and Occurrence of Rheumatoid Arthritis in Patients From Federation of Bosnia and Herzegovina. art, Cilt: 32 - Sayı: 4, 290–297. https://ajindex.com/articles/351675

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Archer JR, Whelan MA, Badakere SS, McLean IL, Archer IV, Winrow VR. Effect of a free sulphydryl group on expression of HLA-B27 specificity. Scand J Rheumatol Suppl 1990;87:44-50
  2. Auger I, Roudier J. HLA-DR and the development of rheumatoid arthritis. Autoimmunity 1997;26:123-8
  3. Boki KA, Panayi GS, Vaughan RW, Drosos AA, Moutsopoulos HM, Lanchbury JS. HLA class II sequence polymorphisms and susceptibility to rheumatoid arthritis in Greeks. The HLA-DR beta shared-epitope hypothesis accounts for the disease in only a minority of Greek patients. Arthritis Rheum 1992;35:749-55
  4. Bridges SL Jr. The genetics of rheumatoid arthritis: influences on susceptibility, severity, and treatment response. Curr Rheumatol Rep 1999;1:164-71
  5. Coenen MJ, Gregersen PK. Rheumatoid arthritis: a view of the current genetic landscape. Genes Immun 2009;10:101-11
  6. Deighton C, Criswell LA. Recent advances in the genetics of rheumatoid arthritis. Curr Rheumatol Rep 2006;8:394-400
  7. Harney S, Wordsworth BP. Genetic epidemiology of rheumatoid arthritis. Tissue Antigens 2002;60:465-73
  8. Jajic I, Kaselan A, Brnobic A, Kerhin V, Brkljacic Lj. HLA antigens in psoriatic arthritis and psoriasis. Arch Dermatol 1977;113:2-4
  9. Jones EY, Fugger L, Strominger JL, Siebold C. MHC class II proteins and disease: a structural perspective. Nat Rev Immunol 2006;6:271-82
  10. Lipsky PE. Reumatoidni artritis. In: Harrison. Principi Interne Medicine. 1st ed. Croatia: Placebo Split Hrvatska; 1997. p. 1443-9
  11. Gonzalez-Escribano MF, Rodriguez R, Valenzuela A, Garcia A, Núñez-Roldan A. Complex associations between HLA-DRB1 genes and female rheumatoid arthritis: results from a prospective study. Hum Immunol 1999;60:1259-65
  12. Harney S, Wordsworth BP. Genetic epidemiology of rheumatoid arthritis. Tissue Antigens 2002;60:465-73
  13. Zanelli E, Breedveld FC, de Vries RR. HLA class II association with rheumatoid arthritis: facts and interpretations. Hum Immunol 2000;61:1254-61
  14. Weyand CM, Goronzy JJ. Inherited and noninherited risk factors in rheumatoid arthritis. Curr Opin Rheumatol 1995;7:206-13
  15. Webb SR, Gascoigne NR. T-cell activation by superantigens. Curr Opin Immunol 1994;6:467-75
  16. Tuokko J, Nejentsev S, Luukkainen R, Toivanen A, Ilonen J. HLA haplotype analysis in Finnish patients with rheumatoid arthritis. Arthritis Rheum 2001;44:315-22
  17. Stark K, Rovensky J, Blazicková S, Grosse-Wilde H, Ferencik S, Hengstenberg C, et al. Association of common polymorphisms in know