AI Summary & Key Takeaways
AI InsightIn76% of cases, PD-L1 expression level was lower than 50%.CONCLUSIONThe findings of our study indicate that PD-L1 quantification using a cell-block approach onCT-guided FNAC is a feasible and safe technique and should be taken into account alongsidewith core biopsy approach, especially in case of advanced disease and/or fragile and olderpatients.
📌 3 Key Takeaways
Özet
PURPOSEWe aimed to evaluate the feasibility, accuracy, and safety of Programmed Death–1/ Programmed Death–Ligand 1 (PD-1/ PD-L1) expression quantification in cytology cell-blocksamples obtained through transthoracic CT-guided fine-needle aspiration cytology (FNAC)from the interventional radiologist’s perspective.METHODSWe performed a consecutive unselected series of 361 CT-guided biopsies of pulmonary nodules and masses which came to our observation from June 2017 to October 2018. For eachcase, exhaustive clinical, morphologic, molecular and tomographic data were available. Allthe material obtained was fixed in formalin to obtain a cell-block for the pathologist, whoperformed immunohistochemical analysis to detect PD-L1 expression levels on each sample.RESULTSOf all the analyzed samples, 93.6% (338/361) were defined to be diagnostic, including neoplastic (72%, 260/361) and non-neoplastic lesions (21.6%, 78/361); only 6.4% (23/361) ofthem resulted in nondiagnostic specimens. Non-small cell lung cancer (NSCLC) accounted for73.8% of neoplastic lesions (192/260): most of them were adenocarcinoma (83%, 160/192),followed by squamous carcinoma (14%, 27/192) and poorly differentiated carcinoma (3%,5/192). In 96% of NSCLC (184/192), the diagnosis was reached either in the absence of complications or with early minor complications. PD-L1 expression was evaluated in all 192 NSCLCcytology specimens: 180 immunostainings were found to be adequate for PD-L1 testing. In76% of cases, PD-L1 expression level was lower than 50%.CONCLUSIONThe findings of our study indicate that PD-L1 quantification using a cell-block approach onCT-guided FNAC is a feasible and safe technique and should be taken into account alongsidewith core biopsy approach, especially in case of advanced disease and/or fragile and olderpatients.