Journals / Çocuk Enfeksiyon Dergisi / 2016 / Cilt: 10 - Sayı: 2

Çocuklarda Alt Solunum Yolu Enfeksiyonu Üzerine D Vitamini Düzeyinin Etkisi Vitamin D ve Alt Solunum Yolu Enfeksiyonu

The Role of Serum Vitamin D Level on Lower Respiratory Tract Infections in Children

Pages
54–59
DOI
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Conclusion: Serum 25 (OH) vitamin D levels were inversely proportional with the severity and frequency of LRTIs.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to evaluate the effect of serum 25 (OH) vitamin D levels on the clinical aspect of acute lower respiratory tract infections (LRTIs) in children.
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Key Findings & Data:Material and Methods: Fifty patients (19 female, 32%) who had been internalized in Haseki Training and Research Hospital, Department of Pediatrics with the diagnosis of LRTIs were enrolled in this study.
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Conclusion & Impact:Conclusion: Serum 25 (OH) vitamin D levels were inversely proportional with the severity and frequency of LRTIs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to evaluate the effect of serum 25 (OH) vitamin D levels on the clinical aspect of acute lower respiratory tract infections (LRTIs) in children. Material and Methods: Fifty patients (19 female, 32%) who had been internalized in Haseki Training and Research Hospital, Department of Pediatrics with the diagnosis of LRTIs were enrolled in this study. Fifty healthy subjects in the same age group constituted the control group. Serum 25 (OH) vitamin D levels were measured by ELISA method. Prenatal, postnatal factors and nutritional status of children that may influence serum 25 (OH) vitamin D levels were also evaluated. Results: The mean age of patients was 34.1±24.3 months. The most common type of LRTIs were bronchiolitis (80%) and bronchopneumonia (20%). The degree of severity was grouped as mild (12%), moderate (64%) and severe (24%). Mean serum 25 (OH) vitamin D level was 45.50±21.82 ng/mL in study group and was 55.18±26.83 ng/mL in control group. There was negative correlation between frequency of LRTIs and serum 25 (OH) vitamin D levels (r=-0.522, p= <0.001). Serum 25 (OH) vitamin D levels in patients with severe LRTIs were significantly lower than the mild and moderate group (p values are 0.007 and 0.004, respectively). Conclusion: Serum 25 (OH) vitamin D levels were inversely proportional with the severity and frequency of LRTIs.

Özet

Amaç: Bu çalışmada çocuklarda serum D vitamini düzeylerinin alt solunum yolu enfeksiyonu (ASYE) üzerine olan etkileri araştırılmak istenmiştir. Gereç ve Yöntemler: Haseki Eğitim Araştırma Hastanesi Çocuk Sağlığı ve Hastalıkları Kliniklerinde Eylül 2012 - Şubat 2013 tarihleri arasında ASYE tanısı ile tedavi edilen 50 hasta çalışmaya alındı. Kontrol grubuna aynı yaş grubundaki sağlıklı 50 olgu dahil edildi. Hastaların ve kontrol grubundaki olguların serum 25 (OH) D vitamini düzeyleri ELISA yöntemiyle ölçüldü. D vitamini düzeyini etkileyebilecek doğum öncesi ve doğum sonrası faktörler ile hastaların beslenme durumu değerlendirildi. Bulgular: Hastaların yaş ortalamaları 34,1±24,3 ay ve %62'si erkekti. Hastaların %80'i bronşiyolit, %20'si bronkopnömoni tanısı almış olup hastalık şiddeti hafif (%12), orta (%64) ve ağır (%24) olarak sınıflandırıldı. Hastaların 25 (OH) D vitamini düzey ortalaması 45,50±21,82 ng/mL iken kontrol grubu serum 25 (OH) D vitamini ortalaması 55,18±26,83 ng/mL saptandı. ASYE geçirme sayısı ile D vitamini düzeyi arasında ters yönde anlamlı ilişki bulundu (r=-0,522, p=<0,001). Ağır hastalığı olan olguların serum 25 (OH) D vitamini düzeyleri hastalık şiddeti hafif ve orta olan gruplara göre daha düşüktü (sırasıyla p=0,007, p=0,004).Sonuç: Bu çalışmada ağır ASYE kliniği olan ve tekrarlayan ASYE tanısı alan hastalarda serum 25 (OH) D vitamini düzeyleri, orta ve hafif hastalık şiddetine sahip olan hastalara göre anlamlı olarak daha düşük bulunmuştur.

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Cite This Article

KOCABEY, Z. S., SÜTÇÜ, M., DURU, H. N. S., ÇİVİLİBAL, M., ELEVLİ, M. (2016). Çocuklarda Alt Solunum Yolu Enfeksiyonu Üzerine D Vitamini Düzeyinin Etkisi Vitamin D ve Alt Solunum Yolu Enfeksiyonu. Çocuk Enfeksiyon Dergisi, Cilt: 10 - Sayı: 2, 54–59. https://ajindex.com/articles/348712

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