Journals / Çocuk Enfeksiyon Dergisi / 2015 / Cilt: 9 - Sayı: 1

İzole hepatit ile başvuran maternal kızamıkçık aşısının neden olduğu doğumsal kızamıkçık infeksiyonu

Presenting with isolated hepatitis caused by congenital rubella infection due to maternal rubella vaccination

Pages
38–41
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Infants who are borne by pregnant women with rubella vaccination should be monitored.

📌 3 Key Takeaways

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Objective & Hypothesis:Congenital rubella syndrome is a transplacental infection that may cause serious devastating damage in the fetus, including intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and hepatitis.
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Key Findings & Data:It is suggested that patients must be screened for pregnancy before vaccination and should be informed regarding contraception for 3 months after vaccination.
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Conclusion & Impact:Infants who are borne by pregnant women with rubella vaccination should be monitored.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Congenital rubella syndrome is a transplacental infection that may cause serious devastating damage in the fetus, including intrauterine growth retardation, cataracts, patent ductus arteriosus, hearing loss, microcephaly, thrombocytopenia, and hepatitis. Rubella vaccine is administered for preventing congenital rubella syndrome. It is suggested that patients must be screened for pregnancy before vaccination and should be informed regarding contraception for 3 months after vaccination. Herein, we presented a 1-month-old boy to whom rubella vaccine was administered. After performing multiple diagnostic studies to exclude other liver disorders, the patient, who had high liver enzymes, was diagnosed with congenital rubella infection by his mother’s history and positive anti-rubella IgM. His liver enzymes returned to normal at 2 months of age of the follow-up period. Negative anti-rubella IgM was revealed at 6 months of age. As a result, when rubella vaccine is administered in pregnancy, high liver enzymes might occur without other congenital rubella syndrome signs in newborns. Infants who are borne by pregnant women with rubella vaccination should be monitored.

Özet

Doğumsal kızamıkçık infeksiyonu intrauterin gelişme geriliği, katarakt, patent duktus arteriozus, işitme kaybı, mikrosefali, trombositopeni, hepatit ve ciddi fetal hasara neden olabilen bir transplasental enfeksiyondur. Konjenital rubella sendromunun önlenmesi için kızamıkçık aşılaması uygulanmaktadır. Aşının uygulanmasından sonra 3 ay hamile kalınmaması veya ilk trimestrde aşı uygulanmaması önerilmektedir. Bu yazıda annesine ilk trimestrde kızamıkçık aşısı uygulanan bir aylık erkek bebek sunuldu. Biyokimyasal incelemelerinde karaciğer fonksiyon testlerinde yükseklik saptanan olgunun karaciğer hastalığı yapabilecek diğer nedenler ekarte edildikten sonra öykü ve kızamıkçık immünglobulin M (IgM) pozitif, kızamıkçık IgGnin yüksek saptanması ile tanı konuldu. Bebeğin izleminde ikinci ayda karaciğer enzimleri normale döndü. Altıncı ayda rubella IgM negatifleşti. Sonuç olarak, hamilelikte kızamıkçık aşısı uygulandığında yenidoğanda, konjenital kızamıkçık sendromunun başka bulgusu olmadan, karaciğer enzim yüksekliği ortaya çıkabileceği düşünüldü. Aşılanmış anneden doğan bebekler bu açıdan da takip edilmelidir.

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Cite This Article

KORKMAZ, H. A., ARSLAN, N., AYDIN, A. (2015). İzole hepatit ile başvuran maternal kızamıkçık aşısının neden olduğu doğumsal kızamıkçık infeksiyonu. Çocuk Enfeksiyon Dergisi, Cilt: 9 - Sayı: 1, 38–41. https://ajindex.com/articles/348602

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