Journals / Kulak Burun Boğaz Klinikleri / 2001 / Cilt: 3 - Sayı: 3

Changes in humoral and cellular immune response in children with chronic tonsillitis

Kronik tonsillitli çocuklarda immün sistemde hümoral ve hücresel değişiklikler

Pages
143–146
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: it seems that humoral and cellular immune responses do not weaken or decrease in chronic or recurrent tonsillitis.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We evaluated the changes in humoral and cellular immune responses in chil-dren with chronic or recurrent tonsillitis.
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Key Findings & Data:Patients and Methods: Twenty-one children (13 girls, 8 boys; age range 2 to 14 years) with chronic or recurrent tonsillitis were studied.
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Conclusion & Impact:Conclusion: it seems that humoral and cellular immune responses do not weaken or decrease in chronic or recurrent tonsillitis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tonsil · Antijenler · CD4

Abstract

Objectives: We evaluated the changes in humoral and cellular immune responses in chil-dren with chronic or recurrent tonsillitis. Patients and Methods: Twenty-one children (13 girls, 8 boys; age range 2 to 14 years) with chronic or recurrent tonsillitis were studied. To evaluate the cellular immunity,$CD_3$ , $CD_4$, $CD_8$ , $CD_19$, $CD_23$, $CD_16$ and $CD_56$ were measured. Total IgG, IgG subgroups ( $G_1$, $G_2$, $G_3$, $G_4$), IgA, IgM and IgE levels were measured to evaluate the humoral system. Complement activity (CHıoo) was also measured. Throat swabs and antibiograms were obtained and antistreptolysin O and complete blood count were routinely measured in the absence of signs of an acute infection. Results: Blood IgE (p<0.05) and IgGı (p<0.001) levels were elevated and the classic pathway of the complement system was found to be significantly active (p<0.005). $CD_3$(p<0.001), $CD_4$ (p<0.001) and $CD_23$ (p<0.001) levels were significantly high. Conclusion: it seems that humoral and cellular immune responses do not weaken or decrease in chronic or recurrent tonsillitis.

Özet

Amaç: Kronik ve reküren tonsillitli çocuklarda hümoral ve hücresel immün sistemdeki değişiklikler araştırıldı. Hastalar ve Yöntemler: Kronik veya reküren tonsillit tanısı konmuş 21 çocuk (13 kız, 8 erkek; yaş dağılımı 2-14) incelendi. Hücresel immüniteyi incelemek için $CD_3$ , $CD_4$, $CD_8$ , $CD_19$, $CD_23$, $CD_16$ ve $CD_56$ düzeyleri araştırıldı. Hümoral immüniteyi incelemek için total immünglobulin IgG, IgG alt grupları ( $G_1$, $G_2$, $G_3$, $G_4$), IgA, IgM ve IgE ölçüldü. CHıoo aktivitesi incelendi. Tüm olgularda hemogram, antistreptolizin O, boğaz kültürü ve antibiyogram rutin olarak incelendi. İncelemeler hastaların akut enfeksiyon bulgularına sahip olmadıkları dönemde yapıldı. Bulgular: Serum IgE (p<0.05) ve IgGı (p<0.001) düzeyleri anlamlı derecede yüksek, kompleman sisteminin klasik yolu ise aktif bulundu (p<0.005). $CD_3$ (p<0.001), $CD_4$ (p<0.001) ve $CD_23$ (p<0.001) düşeyleri da anlamlı derecede yüksekti. Sonuç: Kronik tonsillitte hümoral ve hücresel immün sistem fonksiyonlarında herhangi bir azalma veya yetersizlik gelişmediği sonucuna varıldı

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Cite This Article

KAYHAN, F. T., ERGEZ, E., HATİPOĞLU, A., GEDİKLİ, O., BÜYÜKKAHRAMAN, G., SEZGİN, B., YİĞİT, Ö., BABALIOĞLU, M. (2001). Changes in humoral and cellular immune response in children with chronic tonsillitis. Kulak Burun Boğaz Klinikleri, Cilt: 3 - Sayı: 3, 143–146. https://ajindex.com/articles/343376