Journals / Kulak Burun Boğaz İhtisas Dergisi / 2006 / Cilt: 16 - Sayı: 2

Prognostic factors and survival rates in oral cavity cancers

Oral kavite kanserlerinde prognostik faktörler ve sağkalım oranları

Pages
64–71
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our data show that tumor size, lymph node involvement, stage, and postoperative adju­vant radiotherapy are significant parameters that affect survival in oral cavity cancers.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We evaluated the treatment results and prognostic factors that might affect local control and survival in patients receiving radiotherapy for oral cavity cancers.
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Key Findings & Data:Patients and Methods: The study included 32 patients (16 men, 16 women; mean age 62 years; range 26 to 90 years) who received radiotherapy for oral cavity can­cers.
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Conclusion & Impact:Conclusion: Our data show that tumor size, lymph node involvement, stage, and postoperative adju­vant radiotherapy are significant parameters that affect survival in oral cavity cancers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kombine tedavi uygulaması · Ağız neoplazmları · Radyasyon dozu

Abstract

Objectives: We evaluated the treatment results and prognostic factors that might affect local control and survival in patients receiving radiotherapy for oral cavity cancers. Patients and Methods: The study included 32 patients (16 men, 16 women; mean age 62 years; range 26 to 90 years) who received radiotherapy for oral cavity can­cers. All the patients had squamous cell carcinoma, which involved the tongue in 15 patients (46.9%) and the lower lip in 13 patients (40.6%). Most of the patients (n=21, 65.7%) had T, or T2 tumors. Neck lymph nodes were positive in 11 patients (34.4%). Fifteen patients had early stage (stage I, II), 17 patients had advanced stage (stage III, IV) tumors. Sixteen patients received primary radiotherapy and 16 patients received postop­erative adjuvant radiotherapy, with doses ranging from 5000 cGy to 7000 cGy. The mean follow-up period was 68 months (range 5 to 147 months). Results: Two-year and five-year survival rates were 53% and 39%, respectively. Age, sex, tumor differentiation", and the total radiotherapy dose were not found to affect survival (p>0.05), whereas tumor size, positive lymph nodes, stage, and treat­ment modality were found as significant prognostic factors (p=0.01). Conclusion: Our data show that tumor size, lymph node involvement, stage, and postoperative adju­vant radiotherapy are significant parameters that affect survival in oral cavity cancers.

Özet

Amaç: Oral kavite kanseri tanısıyla radyoterapi uy­gulanan hastalarda tedavi sonuçları, lokal kontrol ve sağkalımı etkileyebilecek prognostik faktörler değer­lendirildi. Hastalar ve Yöntemler: Oral kavite kanseri nede­niyle radyoterapi uygulanan 32 hasta (16 erkek, 16 kadın; ort. yaş 62; dağılım 26-90) çalışmaya alındı. Tüm hastalarda tümör yassı hücreli karsinomdu. On beş hastada (%46.9) dil, 13 hastada (%40.6) alt dudak kanseri vardı. Hastaların çoğu T1( T2 tümör­le (21 hasta, %65.7) başvurmuştu; 11'inde (%34.4) boyun lenf nodları pozitifti. On beş hasta erken ev­re (evre I, II), 17 hasta ileri evredeydi (evre III, IV). On altı hasta primer radyoterapi, 16 hasta ameliyat sonrası adjuvan radyoterapi ile tedavi görmüştü. Radyoterapi dozu 5000-7000 cGy arasında değişi­yordu. Hastaların ortalama takip süresi 68 ay (da­ğılım 5-147 ay) idi. Bulgular: İki yıllık ve beş yıllık sağkalım oranları sı­rasıyla %53 ve %39 olarak hesaplandı. Yaş, cinsi­yet, tümör diferansiasyonu ve toplam radyoterapi dozunun sağkalımı anlamlı olarak etkilemediği gö­rüldü (p>0.05). Tümör büyüklüğü, boyun lenf nodu tutulumu, evre ve tedavi yönteminin sağkalımı an­lamlı etkilediği görüldü (p=0.01). Sonuç: Çalışmamızda tümör büyüklüğü, lenf nodu tutulumu, evre ve ameliyat sonrası adjuvan radyote­rapi, oral kavite kanserlerinde sağkalımı anlamlı ola­rak etkileyen faktörler olarak bulundu.

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Cite This Article

UĞURLUER, G., ÖZYURT, S. C., AKSARAY, F., ASLAN, N., HABİBOĞLU, R., TÜMÖZ, M. (2006). Prognostic factors and survival rates in oral cavity cancers. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 16 - Sayı: 2, 64–71. https://ajindex.com/articles/343308

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