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Journals / Kulak Burun Boğaz İhtisas Dergisi / 2015 / Cilt: 25 - Sayı: 6

Mean platelet volume play a role in disease severity in patients with obstructive sleep apnea syndrome?

Tıkayıcı uyku apne sendromunda ortalama trombosit hacminin hastalık şiddetinde rolü var mıdır?

Erkan ESEN
FATİH ÖZDOĞAN
HALİL ERDEM ÖZEL
Zahide YILMAZ
Turgut YÜCE
Serdar BAŞER
Selahattin GENÇ
Adın SELÇUK
Pages
343–345
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a negative acute phase reactant, MPV can be used as a marker to exert the cardioprotective effect of CPAP.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to show the effects of nasal continuous positive airway pressure (CPAP) treatment on platelet activation in patients with severe obstructive sleep apnea syndrome (OSAS).
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Key Findings & Data:Patients and Methods: Forty-six patients (29 males, 17 females; mean age 48.2±7.6 years; range 40 to 56 years) with severe OSAS with apnea/hypopnea index (AHI) ≥30 were included in this study.
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Conclusion & Impact:As a negative acute phase reactant, MPV can be used as a marker to exert the cardioprotective effect of CPAP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to show the effects of nasal continuous positive airway pressure (CPAP) treatment on platelet activation in patients with severe obstructive sleep apnea syndrome (OSAS). Patients and Methods: Forty-six patients (29 males, 17 females; mean age 48.2±7.6 years; range 40 to 56 years) with severe OSAS with apnea/hypopnea index (AHI) &#8805;30 were included in this study. Complete blood counts were analyzed and mean platelet volume (MPV) values were compared in patients before and after CPAP treatment at six months. Results: The mean MPV values before CPAP were 8.9±1.3 (p<0.001), while the mean values were 7.7±1.1 (p<0.001) at six months after CPAP treatment in patients with severe OSAS. There was a statistically significant decrease in the MPV values after CPAP treatment. Patients’ number of platelets which was measured six months after the CPAP treatment increased at a significant level compared to baseline (p<0.001). Conclusion: Continuous positive airway pressure treatment caused a significant decrease in the MPV values in patients with severe OSAS. As a negative acute phase reactant, MPV can be used as a marker to exert the cardioprotective effect of CPAP.

Özet

Amaç: Bu çalışmada, ağır tıkayıcı uyku apnesi sendromlu hastalarda (TUAS) kullanılan sürekli pozitif hava yolu basıncı (CPAP) tedavisinin trombosit aktivitesi üzerindeki etkisi gösterildi. Hastalar ve Yöntemler: Bu çalışmaya apne/hipopne indeksi (AHİ) ≥30 olan şiddetli TUASlı 46 hasta (29 erkek, 17 kadın; ort. yaş 48.2±7.6 yıl; dağılım 40-56 yıl) alındı. Hastaların CPAP tedavisi öncesi ve sonrası altıncı ayda tam kan sayımları ölçüldü ve ortalama trombosit hacim (OTH) değerleri karşılaştırıldı. Bulgular: Şiddetli TUASlı hastaların CPAP öncesi OTH değerleri ortalama 8.9±1.3 (p<0.001) iken, CPAP tedavisi sonrasında altıncı ayda değerler ortalama 7.7±1.1 (p<0.001) idi. Sürekli pozitif hava yolu basıncı tedavisinden sonra OTH değerlerinde istatistiksel olarak anlamlı bir düşüş gözlendi. Hastaların CPAP tedavisi sonrası altıncı ayda ölçülen trombosit sayısı başlangıca göre anlamlı düzeyde arttı (p<0.001). Sonuç: Sürekli pozitif hava yolu basıncı tedavisi, şiddetli TUASlı hastalarda OTH değerlerinde belirgin bir düşüşe neden olmuştur. Negatif akut faz reaktantı olarak, OTH CPAPın kardiyoprotektif etkisini göstermede bir belirteç olarak kullanılabilir.

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Cite This Article

ESEN, E., ÖZDOĞAN, F., ÖZEL, H. E., YILMAZ, Z., YÜCE, T., BAŞER, S., GENÇ, S., SELÇUK, A. (2015). Mean platelet volume play a role in disease severity in patients with obstructive sleep apnea syndrome?. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 25 - Sayı: 6, 343–345. https://ajindex.com/articles/342466

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