Journals / Kulak Burun Boğaz İhtisas Dergisi / 2015 / Cilt: 25 - Sayı: 1

count in children with obstructive sleep apnea syndrome Tıkayıcı uyku apne sendromu olan çocuklarda ortalama trombosit hacmi ve ortalama trombosit hacminin trombosit sayısına oranının değerlendirilmesi

Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome

Pages
16–21
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Adenotonsillectomy may reduce this risk significantly.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to determine the association between obstructive sleep apnea syndrome (OSAS) caused by adenotonsillar hypertrophy and mean platelet volume (MPV) and MPV/platelet count ratio in children, and to evaluate the impact of adenotonsillectomy on these two parameters.
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Key Findings & Data:Patients and Methods: This prospective study consisted of 73 child patients (38 boys, 35 girls; mean age 8.6±3.3 years, range 2 to 17 years) with chronic adenotonsillar hypertrophy who applied to Gaziosmanpaşa University Faculty of Medicine, Ear, Nose and Throat policlinics due to witnessed apnea and snoring in January 2011 and January 2013.
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Conclusion & Impact:Adenotonsillectomy may reduce this risk significantly.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to determine the association between obstructive sleep apnea syndrome (OSAS) caused by adenotonsillar hypertrophy and mean platelet volume (MPV) and MPV/platelet count ratio in children, and to evaluate the impact of adenotonsillectomy on these two parameters. Patients and Methods: This prospective study consisted of 73 child patients (38 boys, 35 girls; mean age 8.6±3.3 years, range 2 to 17 years) with chronic adenotonsillar hypertrophy who applied to Gaziosmanpaşa University Faculty of Medicine, Ear, Nose and Throat policlinics due to witnessed apnea and snoring in January 2011 and January 2013. Also, 56 age and sex matched pediatric patients (28 boys, 26 girls; mean age 8.0±3.2 years; range 3 to 13 years) who admitted to our clinic due to reasons besides OSAS were included in the study as control group. Preoperative and postoperative third month hemoglobin, white blood cell, thrombocyte count, and MPV values of the patients were recorded. Results: Although ratio of MPV/platelet count was higher in patient group than in control group, the difference was not statistically significant. Mean platelet volume level was 7.68±1.07 fL in patient group and 7.21±0.84 fL in control group. Preoperative MPV level in patient group was significantly higher than that in control group (p<0.05). A statistically significant decrease was detected in postoperative third month MPV level and platelet count compared with preoperative MPV and platelet count (7.68±1.07 fL and 7.17±0.97 fL, respectively; p<0.05). Conclusion: High MPV and MPV/platelet count in children with adenotonsillar hypertrophy may be an important risk factor for cardiopulmonary and cerebrovascular morbidities which may develop both in childhood and in adulthood. Adenotonsillectomy may reduce this risk significantly.

Özet

Amaç: Bu çalışmada çocuklarda adenotonsiller hipertrofinin neden olduğu tıkayıcı uyku apne sendromu (TUAS) ile ortalama trombosit hacmi (OTH) ve OTH/trombosit sayısı oranı arasındaki ilişki belirlendi ve adenotonsillektominin bu iki parametre üzerindeki etkisi değerlendirildi. Hastalar ve Yöntemler: Bu prospektif çalışmaya Ocak 2011 - Ocak 2013 tarihleri arasında Gaziosmanpaşa Üniversitesi Tıp Fakültesi Hastanesi Kulak Burun Boğaz Polikliniğine tanıklı apne ve horlama nedeni ile başvuran, kronik adenotonsiller hipertrofisi olan 73 çocuk hasta (38 erkek, 35 kız; ort. yaş 8.6±3.3 yıl; dağılım 2-17 yıl) dahil edildi. Ayrıca kliniğimize TUAS dışı nedenlerle başvuran, yaş ve cinsiyet uyumlu 56 çocuk hasta (28 erkek, 26 kız; ort. yaş 8.0±3.2 yıl; dağılım 3-13 yıl) kontrol grubu olarak çalışmaya alındı. Hastaların ameliyat öncesinde ve ameliyat sonrası üçüncü ayda hemoglobin, beyaz kan hücresi, trombosit sayısı ve OTH değerleri kaydedildi. Bulgular: Hasta grubunda OTH/trombosit sayısı oranı kontrol grubuna göre yüksek olsa da fark istatistiksel olarak anlamlı değildi. Ortalama trombosit hacmi düzeyi hasta grubunda 7.68±1.07 fL, kontrol grubunda 7.21±0.84 fL idi. Ameliyat öncesi OTH düzeyi hasta grubunda kontrol grubundan anlamlı olarak yüksekti (p<0.05). Ameliyat sonrası üçüncü aydaki OTH düzeyi ve trombosit sayısında ameliyat öncesi OTH düzeyi ve trombosit sayısına göre istatistiksel olarak anlamlı bir azalma saptandı (sırasıyla, 7.68±1.07 fL; 7.17±0.97 fL; p<0.05). Sonuç: Adenotonsiller hipertrofili çocuklarda yüksek OTH ve OTH/trombosit sayısı, hem çocukluk hem de yetişkin dönemde gelişebilen kardiopulmoner ve serebrovasküler morbiditeler için önemli bir risk faktörü olabilir. Adenotonsillektomi bu riski anlamlı olarak azaltabilir.

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Cite This Article

SOYALIÇ, H., SOMUK, B. T., DOĞRU, S., GÜRBÜZLER, L., GÖKTAŞ, G., EYİBİLEN, A. (2015). count in children with obstructive sleep apnea syndrome Tıkayıcı uyku apne sendromu olan çocuklarda ortalama trombosit hacmi ve ortalama trombosit hacminin trombosit sayısına oranının değerlendirilmesi. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 25 - Sayı: 1, 16–21. https://ajindex.com/articles/342449

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