SavedAdd your journal

Journals / Namık Kemal Tıp Dergisi / 2020 / Cilt: 8 - Sayı: 2

The Effect of Prognostic Nutritional Index on Prognosis in Small Cell Lung Cancer: Single Center Experience

KÜÇÜK HÜCRELİ AKCİĞER KANSERİNDE PROGNOSTİK NUTRİSYONEL İNDEKSİN PROGNOZ ÜZERİNE ETKİSİ: TEK MERKEZ DENEYİMİ

Esma TÜRKMEN BEKMEZ
Pages
158–162
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Aim: The aim of this study is to investigate the effect of prognostic nutritional index parameter on overall survival in small cell lung cancer patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim of this study is to investigate the effect of prognostic nutritional index parameter on overall survival in small cell lung cancer patients.
📊
Key Findings & Data:Results: Of the 52 patients in our study, 47 were male and 5 were female.
💡
Conclusion & Impact:There was no relationship between overall survival and gender, age, and LDH status.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study is to investigate the effect of prognostic nutritional index parameter on overall survival in small cell lung cancer patients. Materials and Methods: Fifty-two small cell lung cancer patients who were diagnosed in our clinic were reviewed retrospectively. Prognostic nutritional index (PNI) was calculated using albumin and lymphocyte value at the time of diagnosis. The relationship between PNI and overall survival was examined. Results: Of the 52 patients in our study, 47 were male and 5 were female. The median age was 62.9 years.The median PNI value was 45. Median progression-free survival was 6.9 months, median overall survival was 8.7 months. In the multivariate analysis, limited stage disease and PNI≥45 were found to be an independent good prognostic factor for overall survival. There was no relationship between overall survival and gender, age, and LDH status.

Özet

Amaç: Küçük hücreli akciğer kanseri hastalarında prognostik nutrisyonel indeks parametresinin genel sağkalım üzerine etkisiniaraştırmaktır.Materyal ve Metot: Kliniğimizde takip edilen 52 küçük hücreli akciğer kanseri hastasının dosyaları retrospektif olarak incelendi. Tanıanındaki albümin ve lenfosit değeri kullanılarak prognostik nutrisyonel indeks (PNİ) hesaplandı. PNİ ile genel sağkalım arasındaki ilişkiincelendi.Bulgular: Hastaların 47’si (%87) erkek, 5’i kadındı. Yaş ortancası 62.9 (48-82) idi. Ortanca PNİ değeri 45 idi. Median progresyonsuzsağkalım süresi 6.9 ay, median genel sağkalım süresi 8.7 ay idi.Çok değişkenli analizde, sınırlı evre hastalık ve PNİ≥45 olması genelsağkalım için bağımsız iyi prognostik faktör olarak saptandı. Genel sağ kalımla cinsiyet, yaş, LDH durumu arasında ilişki saptanmadı.Sonuç: Çalışmamızda prognostik nutriyonel indeks ve sınırlı evre hastalığın genel sağkalım açısından iyi prognostik bir faktör olduğunusaptadık.

🔖

Cite This Article

BEKMEZ, E. T. (2020). The Effect of Prognostic Nutritional Index on Prognosis in Small Cell Lung Cancer: Single Center Experience. Namık Kemal Tıp Dergisi, Cilt: 8 - Sayı: 2, 158–162. https://ajindex.com/articles/341132

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global Cancer Statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108
  2. World Health Organization. International Agency for Research on Cancer, Section of Cancer Information. Cancer Incidence and Mortality Worldwide, 2008
  3. National comprehensive cancer Network. Clinical practice guidelines. Small cell lung cancer. Available at: may 5, 2015
  4. Stinchcombe TE, Gore EM. Limited-stage small cell lung cancer: current chemoradiotherapy treatment paradigms. Oncologist 2010;15:187-195
  5. Demedts IK, Vermaelen KY, van Meerbeeck JP. Treatment of extensive stage small cell lung carcinoma: current status and future prospects. Eur Respir J 2010;35:202-215
  6. Foster NR, Mandrekar SJ, Schild SE, et al. Prognostic factors differ by tumor stage for small cell lung cancer: a pooled analysis of North Central Cancer treatment group trials. Cancer 2009; 115:2721-2731
  7. Albain KS, Crowley JJ, LeBlanc M, Livingston RB. Determinants of improved outcome in small cell lung cancer: an analysis of the 2,580-patient Southwest Oncology Group data base. J Clin Oncol 1990;8:1563-1574
  8. Hayat MJ, Howlader N, Reichman ME, Edwards BK. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist. 2007;12(1):20–37 9. Zatloukal P, Cardenal F, Szczesna A, Gorbunova V, Moiseyenko V, Zhang X, et al. A multicenter international randomized phase III study comparing cisplatin in combination with irinotecan or etoposide in previously untreated small-cell lung cancer patients with extensive disease. Ann Oncol. 2010;21(9):1810–6
  9. Kubota K, Hida T, Ishikura S, Mizusawa J, Nishio M, Kawahara M, et al. Etoposide and cisplatin versus irinotecan and cisplatin in patients with limited-stage small-cell lung cancer treated with oposide and cisplatin plus concurrent accelerated hyperfractionated thoracic radiotherapy (JCOG0202): a randomised phase 3 study. Lancet Oncol. 2014;15(1):106–13
  10. Candido, J, Hagemann, T. Cancer-related inflammation. J Clin Immunol 2013; 33 Suppl 1: S79–84
  11. Sapienza, C, Issa, JP. Diet, nutrition, and cancer epigenetics. Annu Rev Nutr 2016; 36: 665–681
  12. Hirahara, N, Tajima, Y, Fujii, Y. Preoperative prognostic nutritional index predicts long-term surgical outcomes in patients with esophageal squamous cell carcinoma. World J Surg 2017; 42 (7): 2199–2208
  13. Sun, K, Chen, S, Xu, J. The prognostic significance of