Journals / Online Türk Sağlık Bilimleri Dergisi / 2021 / Cilt: 6 - Sayı: 2

Investigation of the Effect of Progesterone Level on In-Vitro Fertilization Success The Day Before Frozen-Thawed Embryo Transfer

Dondurulmuş Çözülmüş Embriyo Transferi Öncesi Günü Progesteron Seviyesinin İn-Vitro Fertilizasyon Başarısına Etkisinin İncelenmesi

Pages
282–290
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: It is observed that pregnancy outcomes are higher in cycles where progesterone levels are progesterone>10.64 ng/ml, and most of the pregnancies that occur result in a live birth.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To observe the effects of serum progesterone concentrations measured on the day before transfer on pregnancy, miscarriage and live birth rates in frozen-thawed embryo transfer (DCE) cycles.
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Key Findings & Data:Materials and Methods: In this retrospective study, the results of 67 ICET cycles performed in a single center between 01.01.2019 and 01.09.2019 were analyzed.
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Conclusion & Impact:Conclusion: It is observed that pregnancy outcomes are higher in cycles where progesterone levels are progesterone>10.64 ng/ml, and most of the pregnancies that occur result in a live birth.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Embriyo transferi · gebelik sonuçları · hormon replasman tedavisi

Abstract

Objective: To observe the effects of serum progesterone concentrations measured on the day before transfer on pregnancy, miscarriage and live birth rates in frozen-thawed embryo transfer (DCE) cycles. Materials and Methods: In this retrospective study, the results of 67 ICET cycles performed in a single center between 01.01.2019 and 01.09.2019 were analyzed. Pregnancy, abortion and live birth outcomes were compared in DCE cycles below and above the threshold value of 10.64 ng/ml of progesterone. Results: According to progesterone concentrations, the age, causes of infertility, stimulation days, body mass index (BMI) values, endometrial thicknesse, and mean number of embryos transferred were similar in the groups. When pregnancy rates were compared in terms of progesterone concentrations, pregnancy rates were significantly higher in the progesterone>10.65 ng/ml group p=0.023. We found that 50% (21) of total pregnancies resulted in a live birth, and 90.5% (19) of pregnancies resulting in live birth consisted of pregnant women whose progesterone levels were progesterone>10.64 ng/ml. Those whose progesterone levels were <10.64 ng/ml constituted 28.6% (12) of positive pregnant women, 83.3% (10) of these pregnancies were found to be with miscarriage, and 16.7% (2) of them resulted with live births. Conclusion: It is observed that pregnancy outcomes are higher in cycles where progesterone levels are progesterone>10.64 ng/ml, and most of the pregnancies that occur result in a live birth.

Özet

Amaç: Dondurulmuş çözülmüş embriyo transfer (DÇET) sikluslarında transfer öncesi gün ölçülen serum progesteron konsantrasyonlarının gebelik, düşük ve canlı doğum oranları üzerine etkilerini gözlemlemek. Materyal ve Metot: Bu retrospektif çalışmada, tek bir merkezde 01.01.2019 ile 01.09.2019 tarihleri arasında gerçekleştirilen 67 DÇET siklus sonuçları incelendi. Progesteron düzeyleri 10,64 ng/ml eşik değerinin altındaki ve üstündeki DÇET sikluslarındaki gebelik, düşük ve canlı doğum sonuçları karşılaştırıldı. Bulgular: Progesteron konsantrasyonlarına göre DÇET gruplarındaki hastaların yaşı, infertilite nedenleri, sitimülasyon gün sayıları, beden kitle indeks (BKİ) değerleri, endometriyum kalınlıkları ve transfer edilen ortalama embriyo sayıları benzerdi. Gebelik oranları karşılaştırıldığında progesteronun>10,65 ng/ml grubunda gebelik oranları anlamlı derecede yüksekti (p=0,023). Toplam gebeliklerin %50 (21)’sinin canlı doğum ile sonuçlandığı, canlı doğumla sonuçlanan gebeliklerin %90,5 (19)’nin progesteron düzeylerinin >10,64 ng/ml olan gebelerden oluştuğu bulundu. Progesteron düzeyleri <10,64 ng/ml olanların pozitif gebelerin %28,6 (12)’sını oluşturduğu, bu gebeliklerin %83,3 (10)’ünün düşük ile, %16,7 (2)’sinin de canlı doğum ile sonuçlandığı bulundu. Sonuç: Progesteron düzeylerinin >10,64 ng/ml olduğu sikluslarda gebelik sonuçlarının daha yüksek olduğu ve oluşan gebeliklerin büyük çoğunluğunun canlı doğumla sonuçlandığı görülmektedir.

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Cite This Article

BUDAK, Ö., ÖZKÜLER, S., DOĞANAY, S., AKDEMİR, N., BOSTANCI, M. S., CEVRİOĞLU, A. S., TOPRAK, V. (2021). Investigation of the Effect of Progesterone Level on In-Vitro Fertilization Success The Day Before Frozen-Thawed Embryo Transfer. Online Türk Sağlık Bilimleri Dergisi, Cilt: 6 - Sayı: 2, 282–290. https://ajindex.com/articles/340708

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References (11)

  1. Bhattacharya S. Maternal and perinatal outcomes after fresh versus frozen embryo transfer-what is the risk-benefit ratio? Fertility and Sterility. 2016;106(2):241-243.
  2. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertility and Sterility. 2012;98(2):368-377.
  3. Wennerholm UB, Henningsen AK, Romundstad LB, Bergh C, Pinborg A, Skjaerven R, et al. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Human Reproduction (Oxford, England). 2013;28(9):2545-2553.
  4. Rienzi L, Gracia C, Maggiulli R, et al. Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance. Human Reproduction Update. 2017;23(2):139-155.
  5. Coates A, Kung A, Mounts E, et al. Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial. Fertility and Sterility. 2017;107(3):723-730.
  6. Mackens S, Santos-Ribeiro S, van de Vijver A, et al. Frozen embryo transfer: a review on the optimal endometrial preparation and timing. Human Reproduction. 2017;32(11):2234-2242.
  7. Groenewoud ER, Cohlen BJ, Macklon NS. Programming the endometrium for deferred transfer of cryopreserved embryos: hormone replacement versus modified natural cycles. Fertility and Sterility. 2018;109(5):768-774.
  8. Yarali H, Polat M, Mumusoglu S, Yarali I, Bozdag G. Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics. 2016;33(10):1287-1304.
  9. Gellersen B, Brosens JJ. Cyclic decidualization of the human endometrium in reproductive health and failure. Endocrine Reviews. 2014;35(6):851-905. Paulson RJ. Hormonal induction of endometrial receptivity. Fertility and Sterility. 2011;96(3):530-535.
  10. Gaggiotti-Marre S, Martinez F, Coll L, et al. Low serum progesterone the day prior to frozen embryo transfer of euploid embryos is associated with significant reduction in live birth rates. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. 2019;35(5):439-442.
  11. Labarta E, Mariani G,