AI Summary & Key Takeaways
AI InsightConclusion: It was found that aggressive combined therapy may yield relatively favorable outcome in patients with advanced laryngeal cancer.
📌 3 Key Takeaways
Abstract
Objectives: To evaluate the results of aggressive combined treatment in patients with advanced laryngeal cancer with dismal prognosis. Patients and Methods: Records of 158 patients with advanced laryngeal cancer receiving palliative treatment were retrospectively evaluated. Results: Treatment included surgery + postoperative radiotherapy and chemotherapy in 86 patients and radiotherapy + chemotherapy in 72 patients. A locoregional control rate of 62.3% was achieved in patients undergoing surgery. Mean disease-free survival was 39 months in patients with locoregional control. Locoregional control was 35.5% in patients in whom surgery was not performed. A statistically significant difference was found between locoregional control rates of the two groups (p<0.05). Conclusion: It was found that aggressive combined therapy may yield relatively favorable outcome in patients with advanced laryngeal cancer.
Özet
Amaç: Umutsuz gibi görünen ileri evre larenks kanserli hastalarda uyguladığımız agresif kombine tedavinin sonuçları değerlendirildi. Hastalar ve Yöntemler: ileri evre larenks kanseri nedeniyle palyatif amaçlı tedavi edilip takip edilen 158 hastanın kayıtları retrospektif olarak incelendi. Bulgular: Çalışma grubunda 86 hastaya cerrahi + postoperatif radyoterapi ve kemoterapi, 72'sine de radyoterapi + kemoterapi uygulandı. Ameliyat edilen hastaların %62.3'ünde lokorejyonel tümör kontrolü sağlandı ve tümör kontrolünün sağlandığı hastalarda ortalama 39 ay hastalıksız yaşam süresi elde edildi. Cerrahi uygulanmayan hastalarda ise lokorejyonel tümör kontrolü olguların %35.5'inde elde edildi; iki grup arasındaki fark istatistiksel olarak anlamlı bulundu (p<0.05). Sonuç: Umutsuz gibi görünen ileri evre larenks kanserli olgularda agresif kombine tedavi ile nispeten iyi sonuçlar alınabileceği görüldü.