AI Summary & Key Takeaways
AI InsightConclusion: With a cut-off level of 20 mU/ml, determination of alpha-glucosidase levels in the seminal plasma has unpromising sensitivity and specificity rates to predict obstructive azoospermia.
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Abstract
Alpha-Glucosidase Test In The Diagnosis Of Epididymal Obstruction-Purpose: To evaluate seminal plasma alpha-glucosidase levels in patients with azoospermia and to determine the diagnostic impact of this particular test on obstructive type of azoospermia. Patients and Methods: One-hundred and eighty-five azoospermic patients presenting with infertility were evaluated. Seminal plasma alpha-glucosidase levels were determined by using Episcreen analysis, and values below 20 mU/ml were accepted in favor of obstruction. The patients were divided into two groups as obstructive and non-obstructive on the basis of transrectal ultrasonography, testicular biopsy and exploratory findings. Results: Out of135 patients 18 had obstructive and 167 had norkdbstructive azoospermia. The mean seminal plasma alpha-glucosidase levels were determined as 29,69±4.80 mU/ml and 26.06±1.35 mU/ml in obstructive and non-obstructive groups, respectively. The difference between the alpha-glucosidase levels was insignificant (p> 0.05) Seminal plasma alpha-glucosidase levels showed poor relationship with epididymal obstruction at 20 mil/ml cut off value (p= 0.0669). This method had a 38.8 % sensitivity and 56.6 % specificity for the diagnosis of obstructive azoospermia. Conclusion: With a cut-off level of 20 mU/ml, determination of alpha-glucosidase levels in the seminal plasma has unpromising sensitivity and specificity rates to predict obstructive azoospermia.
Özet
infertilite sorunu ile basvuran ve tetkikler sonucunda azoospermi saptanan olgularda seminal plazma alfa-glukozidaz duzeylerinin degerlendirilmesi ve obstruktif azoospermideki tanisal degerinin arastinlmasi. Hastalar've Yontem: infertilite nedeni ile basvuran 185 azoospermik hasta galismaya alindi. Seminal plazma alfa-glukozidaz duzeyi Episcreen test ile gahsildi ve 20 mU/ml'nin altindaki degerler obstruksiyon lehine kabul edildi. Hastalar transrektal ultrason, biyopsi ve eksplorasyon bulgularma,,g6re obstruktif ve non-obstriiktif olarak iki gruba ayrildi. Gruplar seminal plazma voliimu ve seminal plazma alfa-g|jkozidaz duzeyleri bakimindan karsilastinldi. Seminal plazma alfa-glukozidaz duzeyinin obstruksiyon ile iliskisi belirlendi. Bulgular: Qalisma sonunda 18 hasta obstruktif, 167 hasta non-obstruktif azoospermi olarak degerlendirildi. Seminal plazma alfa-glukozidaz duzeyi obstruktif grupta 29.69±4.80 mU/ml, non-obstruktif grupta 26.06±1.35 mU/ml olarak olguldu. Gruplar arasinda istatistiksel olarak anlamli fark yoktu (p> 0.05). Kestirim degeri olarak 20 mU/ml almdiginda seminal alfa-glukozidazin epididimal obstruksiyon ile iliskisi zayif bulundu (p= 0.0669). Yontemin sensitivitesi % 38.8, spesifisitesi % 52.7 olarak belirlendi. Sonug: Obstruktif azoospermi tanisinda alfa-glukozidazin, 20 mU/ml kestirim degeri almdiginda, diisuk sensitivite ve spesifisiteye sahip oldugu kanisma vanldi.