Is the thyroid function a risk factor for obesity?

Key Findings & Data:Retrospective analysis was carried out on 257 obese (VK􀃸>30 kg/m2, 230 women, 27 men), 197 over-weight patients (VK􀃸 25-30 kg/m2, 196 women, 1 man), 190 control healthy group (VK􀃸<25 kg/m2,189 women, 1 man), total 644 subject.

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Conclusion & Impact:We reached this result that TSH is a risk factor in obesity as independent from the thyroid functions.

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

We wanted to investigate the relationship between circulating TSH levels and adiposity in obese people. We asked about thyroid dysfunctions in history of obese patients. It was determined euthyroid, hypothroid, hyperthyroid subjects. Retrospective analysis was carried out on 257 obese (VK􀃸>30 kg/m2, 230 women, 27 men), 197 over-weight patients (VK􀃸 25-30 kg/m2, 196 women, 1 man), 190 control healthy group (VK􀃸<25 kg/m2,189 women, 1 man), total 644 subject. TSH, free thyroxine (FT4), free triiodothyronine (FT3), fasting plasma levels of insulin and glucose, homeostasis model assessment (HOMA) for insulin resistance (HOMA-IR) body weight, height, body mass index (VK􀃸) and waist circumference were assessed. Hypothyroid subjects were found 20 in obese group, 28 in control group as subclinic hypothyroid, 8 in obese group, 5 in control group as manifest hypothyroid. Serum TSH levels were higher in the obese than in the control subjects. In the study group (control and obese subjects), there was a significant positive correlation between serum TSH and body weight, waist circumference, fasting insulin, and HOMA-IR, there was no correlation between serum FT4 and any of the parameters. A multivariate linear regression analysis revealed that only VK􀃸 contributed significantly to the variance of TSH. We reached this result that TSH is a risk factor in obesity as independent from the thyroid functions.

Özet

Obezitede adiposite ve tiroid fonksiyonları arasındaki ilişkiyi incelemek istedik. Hastalar anamnezlerinde tiroid hastalıkları olup olmadığı açısından sorgulandı. Aşikar, subklinik hipotiroidi ve ötiroid olanlar belirlendi. Çalış-maya 230 kadın 27 erkek olmak üzere 257 obez, 196 kadın, 1 erkek olmak üzere 197 fazla kilolu, 189 kadın, 1 erkek olmak üzere 190 kontrol grubu (VKİ<25 kg/m2), toplam olarak 644 kişi retrospektif olarak alındı. TSH, serbest T4 (FT4), serbest T3 (FT3), açlık plazma insülini ve glukozu, insülin rezistansı için HOMA-IR, kilo, boy, vücut kitle indeksi (VKİ), bel çevresi değerlendirildi. Obez olan grupta 20 subklinik, 8 aşikar, kontrol grupta 28 subklinik, 5 aşikar hipotiroidik vakaya rastlandı. Obezlerde TSH değerleri kontrol grubuna göre daha yüksek bulundu, aralarında pozitif ilişki saptandı. Ancak FT4, FT3 ile obezite arasında anlamlı ilişki saptanmadı. Obezite ile TSH, kilo alımı, VKİ, bel çevresi, açlık insülin, HOMA-IR aralarında posizif korelasyon bulundu. Multiva-riant lineer regresyon analizi yapıldığında VKİ’nin TSH’ya önemli katkı sağladığı görüldü. Obezite tiroid fonksiyon-larından bağımsız olarak artmış TSH düzeyleriyle ilişkili olarak görüldü. Bu da bizi obezlerde TSH tiroid fonksiyon-larından bağımsız bir risk faktörüdür sonucuna ulaştırdı.

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Cite This Article

KARAKURT, F., ÇARLIOĞLU, A., KÖROĞLU, M., UZ, B., KASAPOĞLU, B. (2009). Is the thyroid function a risk factor for obesity?. Yeni Tıp Dergisi, Cilt: 26 - Sayı: 1, 27–30. https://ajindex.com/articles/338349

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