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Journals / Yeni Tıp Dergisi / 2011 / Cilt: 28 - Sayı: 2

Outcome of hereditary thrombophilia managed with salicylic acid and low molecular weight heparin in pregnancy

Herediter trombofili tanısı alan hastalarda aspirin ve düşük molekül ağırlıklı heparin tedavisi ile gebelik sonuçları

E. Didem ÖZDEMİR
Gamze S. ÇAĞLAR
EFSER ÖZTAŞ
Sevim Dinçer CENGİZ
Pages
87–91
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, intrauterine growth retardation and oligohydroamnios seen in 25% and 20% of the cases respectively, might indicate placental microthrombosis despite salicylic acid and low molecular weight heparin therapy.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Hereditary thrombophilia is associated with adverse pregnancy outcomes and thromboembolic events during pregnancy.
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Key Findings & Data:Fourty six pregnancies of 42 patients were followed and managed with salicylic acid and low molecular weight heparin when pregnancy was diagnosed.
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Conclusion & Impact:However, intrauterine growth retardation and oligohydroamnios seen in 25% and 20% of the cases respectively, might indicate placental microthrombosis despite salicylic acid and low molecular weight heparin therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Gebelik sonucu · Düşük · tekrarlayan

Abstract

Objective: Hereditary thrombophilia is associated with adverse pregnancy outcomes and thromboembolic events during pregnancy. There is still controversy on the management and optimal treatment when gene mutations of hereditary thrombophilias are detected. Methods: Patients with a past medical history of more than two pregnancy losses and pregnancies associated with thrombosis are investigated. Fifty four patients were detected to have genetic mutations of thrombophilia. Fourty six pregnancies of 42 patients were followed and managed with salicylic acid and low molecular weight heparin when pregnancy was diagnosed. Results: Pregnancy outcomes of these cases were analyzed. Pregnancies occurring before the diagnosis of the hereditary trombophilias resulted in abortion or biochemical pregnancy in 81% and 14% of these pregnancies were complicated by preterm delivery, preterm premature rupture of membranes or preeclampsia. After the administration of salicylic acid and low molecular weight heparin, only 4,3% of these pregnancies resulted in abortion and the live birth rate was 95,6%. Conclusions: Considering the above results, salicylic acid and low molecular weight heparin therapy might help in early pregnancy complications that might be related with placental pathologies. However, intrauterine growth retardation and oligohydroamnios seen in 25% and 20% of the cases respectively, might indicate placental microthrombosis despite salicylic acid and low molecular weight heparin therapy.

Özet

Amaç: Herediter trombofililer, kötü gebelik sonuçları ve tromboembolik olaylarla ilişkili bir durumdur. Herediter trombofili gen mutasyonları saptandığında tedavi ile ilgili halen tartışmalar mevcuttur. Bulgular: Bu çalışmada polikliniğimize tekrarlayan gebelik kayıpları, önceki gebeliklerinde tromboz şikayeti ve bebek istemi ile başvuran hastaları ele aldık. Yapılan taramalarda trombofili gen analizinde mutasyonları olan 54 hasta herediter trombofili tanısı aldı. Takipte 42 hastanın 46 gebeliği aspirin ve düşük molekül ağırlıklı heparin tedavisi ile izlendi. Sonuç: Gebelik sonuçlarını retrospektif olarak değerlendirdik. Hastaların tedavi almadıkları önceki gebeliklerine baktığımızda %81 oranında düşük/biyokimyasal abort ve %14 erken doğum, erken membran rüptürü ve preeklampsiye bağlı fetal kayıp mevcuttu. Tedavi sonrası ise %4,3 abortus izlenirken, canlı doğum oranları %95,6 olarak tespit edildi. Tartışma: Bu veriler ışığında heparin ve aspirin tedavisi muhtemel plasental patolojiye bağlı erken gebelik komplikasyonlarını azaltıyor olabilir ancak intrauterin gelişme geriliğinin %25 ve oligohidramniosun %20 oranında tespit edilmesi plasental mikrotrombüslere bağlı tedavi ile önlenemeyen bir patolojiyi akla getirmektedir.

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Cite This Article

ÖZDEMİR, E. D., ÇAĞLAR, G. S., ÖZTAŞ, E., CENGİZ, S. D. (2011). Outcome of hereditary thrombophilia managed with salicylic acid and low molecular weight heparin in pregnancy. Yeni Tıp Dergisi, Cilt: 28 - Sayı: 2, 87–91. https://ajindex.com/articles/338265

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References (14)

  1. Brenner B. Should thromboprophylaxis be used in hereditary thrombophilias with RPL? in: Ja Carp H, editors. 1st ed. Recurrent Pregnancy Loss Causes, Controversies and Treatment. Taylor&Francis 2007; p: 139-42
  2. Backos M, Regan L. Recurrent Miscarriage. in: James DK, Steer PJ, Weiner CP, Gonik B, editors. 3rd ed. High risk pregnancy. Saunders: Elsevier 2006; p: 105-6
  3. Simpson JL, Jaunıaux ERM. Pregnancy loss. in: Gabbe SG, Niebyl JR, Simpson JL, editors. 5th ed. Obsterics Normal and Problem Pregnancies. Churchill Livingstone: Elsevier 2007; p: 628-49
  4. Inbal A, Ja Carp H. Defects in coagulation factor leading to recurrent pregnancy loss. in: Ja Carp H, editors. 1st ed. Recurrent Pregnancy Loss Causes Controversies and Treatment. Taylor&Francis 2007; p: 127-37
  5. Lindqvist PG. Should thromboprophylaxis be used in hereditary thrombophilias with RPL? Against. in: Ja Carp H, editors. 1st ed. Recurrent Pregnancy Loss Causes, Controversies and Treatment. Taylor&Francis 2007; p: 143-64
  6. Rodger MA, Paidas M, McLintock C, Middeldorp S, Kahn S, Martinelli I, et al. Inherited thrombophilia and pregnancy complications revisited. Obstet Gynecol 2008;112(2 Pt 1):320-4
  7. Patnaik MM, Haddad T, Morton CT. Pregnancy and thrombophilia. Expert Rev Cardiovasc Ther 2007;5(4):753-65
  8. Xu WH, Shrubsole MJ, Xiang YB, Cai Q, Zhao GM, Ruan ZX, et al. Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2007;16(2):281-7
  9. Paynter RA, Hankinson SE, Hunter DJ, De Vivo I. No association between MTHFR 677 C->T or 1298 A->C polymorphisms and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev 2004;13(6):1088-9
  10. Kang SS, Wong PW, Susmano A, Sora J, Norusis M, Ruggie N. Termolabile methylenetetrahydrofolate reductase:an inherited risk factor for coroner artery disease. Am J Hum Genet 1991;48(3):536-45
  11. Wainfan E, Poirier LA. Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res 1992;1;52(7 suppl): 2071s-2077s
  12. Sharp L, Little J. Polymorphism in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 2004 1;159(5):423-43
  13. Gülec S, Aras O, Akar E, Tutar E, Ömürlü K, Avci F, et al. Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction. Clin Cardiol 2001;24(4):281-4
  14. Souza SS, Ferriani RA, Pontes AG, Zago MA, Franco RF. Factor V leiden and factor