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Journals / Yeni Tıp Dergisi / 2012 / Cilt: 29 - Sayı: 4

Effects of N-acetyl cysteine in lower extremity motor function in prevention of ischemia–reperfusion injury

Medulla spinalisin iskemi-reperfüzyon hasarını önlemede kullanılan N-asetil sisteinin alt ekstremite motor fonksiyonlarına etkisi

Kemalettin ERDEM
Celal YAVUZ
Ömer ÇAKIR
Pages
214–217
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our study demonstrated that NAC has a protective effect in prevention of ischemic reperfusion injury of the spinal cord.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Spinal cord injuries such as paraplegia and paraparesis are still the most devastating complications of surgery for descending thoracic aortic aneurysm.
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Key Findings & Data:Material and Method: Eighten rabbits were divided into three equal groups, group I (sham-operated), group II (control), and group III (NAC-50 mg/kg).
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Conclusion & Impact:Conclusion: Our study demonstrated that NAC has a protective effect in prevention of ischemic reperfusion injury of the spinal cord.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tavşanlar · Omurilik yaralanmaları · Reperfüzyon hasarı

Abstract

Objective: Spinal cord injuries such as paraplegia and paraparesis are still the most devastating complications of surgery for descending thoracic aortic aneurysm. To prevent these complications recommended a variety of spinal cord protection methods but no one achieved a complete protection. The purpose of this study was to investigate the effect of N-acetylcysteine (NAC) on the protection of the spinal cord ischemic reperfusion injury. Material and Method: Eighten rabbits were divided into three equal groups, group I (sham-operated), group II (control), and group III (NAC-50 mg/kg). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Forty-eight hours postoperatively, the motor function of the lower limbs was evaluated in each animal according to Tarlov Score. Results: The sham-operated rabbits (group I) showed no neurologic deficit (Score=4). Paraplegia (Score=0) developed in all rabbits in the control group (group II). Administration of 50 mg/kg of NAC (group III) resulted in one rabbit in 2, one rabbit in 3 and other four rabbit 4 Tarlov scores. Application of NAC, showed significant recovery of motor functions (Score= 3.1+/-1.3, p= 0.002). Conclusion: Our study demonstrated that NAC has a protective effect in prevention of ischemic reperfusion injury of the spinal cord.

Özet

Amaç: Desenden torasik ve torakoabdominal aortaya yapılan başarılı bir operasyonu takiben spinal kord hasarı ağır ve beklenmedik bir komplikasyondur. Bu komplikas-yondan korunmak için çeşitli spinal kord koruma metot-ları ileri sürülmüş fakat hiç birinde tam bir korunma sağlanamamıştır. Çalışmamızda hastalarda sıklıkla kulla-nılan N-Asetil Sisteinin (NAS) medulla spinalisin iskemik reperfüzyon hasarından korunması üzerine olan etkisini araştırmayı amaçladık. Materyal ve Metot: Üç eşit gruba ayrılmış her grupta 6 tavşan olan toplam 18 tavşanla yapıldı. Grup I (basit operasyon n=6), anestezi ve laparatomi yapıldı, aortik oklüzyon yapılmadı. Grup II (kontrol grubu n=6), farma-kolojik ilaç uygulanmayıp sadece renal arterin altında iliyak bifurkasyonun üzerinden abdominal aortaya 45 dakika aortik kross klemp uygulandı. Grup III (NAS grubu), 50 mg/kg NAS infüzyon şeklinde aortik kross-klemp kaldırılmadan 15 dakika önce başlandı ve dört saat süresince devam edildi. Tüm tavşanların alt ekstre-mite motor fonksiyonları 48 saat sonra Tarlow skoru ile değerlendirildi. Bulgular: Basit operasyon grubundaki hiçbir tavşanda parapleji gelişmedi. Kontrol grubundaki tavşanların tamamında parapleji gelişti. NAS grubundaki tavşanların skorlaması: tavşanlardan birinde Tarlow 3, ikisinde Tarlow 2, dört tavşanda Tarlow 4 olarak değerlendirildi. NAS uygulanmasının motor fonksiyonlarda anlamlı düzel-meye neden olduğu saptandı (Tarlov Skoru=3,1+/-1,3, p= 0.002). Sonuç: Çalışma spinal kordun iskemik reperfüzyon hasarından korunmasında N-Asetil sisteminin koruyucu etkiye sahip olduğunu gösterdi.

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Cite This Article

ERDEM, K., YAVUZ, C., ÇAKIR, Ö. (2012). Effects of N-acetyl cysteine in lower extremity motor function in prevention of ischemia–reperfusion injury. Yeni Tıp Dergisi, Cilt: 29 - Sayı: 4, 214–217. https://ajindex.com/articles/338245

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