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Journals / Zeynep Kamil Tıp Bülteni / 2012 / Cilt: 43 - Sayı: 2

Gestational trophoblastic disease and Follow-up Ratio

Gestasyonel Trofoblastik Hastalıklar ve Takip Oranları

Özgür Aydın TOSUN
Pınar BATU
l Arzu ARINKAN³
Ertuğrul YILMAZ
Çetin ÇAM
Ateş KARATEKE
Pages
53–57
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Regular follow up at specialized clinics is extremely important for the proper management of the disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Gestational trophoblastic disease is a heterogeneous group of diseases characterized by invasion of abnormally proliferating trophoblastic tissue to the endometrium and myometrium.
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Key Findings & Data:Material and methods: This retrospective study was performed including the patients who had GTH diagnosis at Zeynep Kamil Hospital between 2000 and 2008.
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Conclusion & Impact:Regular follow up at specialized clinics is extremely important for the proper management of the disease.
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Domain Parameters

Abstract

Gestational trophoblastic disease is a heterogeneous group of diseases characterized by invasion of abnormally proliferating trophoblastic tissue to the endometrium and myometrium. Diagnosis is histopathologically following vacuum curettage. Purpose of this research is to determine the follow-up ratio of patients who had GTD. Material and methods: This retrospective study was performed including the patients who had GTH diagnosis at Zeynep Kamil Hospital between 2000 and 2008. Statistical analysis was performed using the SPSS 12 program. Chi-square test was used for statistical analysis. P values were considered to be statistically significant at P < 0.05. Results: 103951 patients were included in this research. 257 of them had GTH diagnosis histopathologically. 5 of them (%1.94) had choriocarcinoma , 3 of them (%1.16) had placental site trophoblastic tumors and 249 of them (%96) had hydatidiform mole .62 of hydatidiform mole cases (%25) did not visit doctors regularly. This ratio is %21 at partial mole cases and %25 complete mole cases respectively. Conclusion: Patients who had GTH diagnosis should be followed regularly. Regular follow up at specialized clinics is extremely important for the proper management of the disease.

Özet

Amaç: Gestasyonel trofoblastik hastalık (GTH), anormal fertilizasyonun bir sonucu olarak gelişen, gebelikte trofoblastın anormal proliferasyonu sonucu endometrium ve myometriumu invazyonu ile karakterize bir hastalık grubudur. Kesin tanı, vakum küretaj sonrası alınan örneğin histopatolojik olarak değerlendirilmesi ile konur. Bu çalışmayla hastanemizde histopatolojik olarak GTH tanısı almış olguların oranlarını ve klinik takip düzeylerinin belirlenmesini amaçladık.Gereç ve yöntemler: 2000-2008 yılları arasında hastanemizde doğum ve abortus yapan olgular ile histopatolojik olarak GTH tanısını alan olguların medikal kayıtları retrospektif olarak incelenmiştir. Çalışmamızda verilerin değerlendirilmesinde SPSS 12.0 paket programı kullanıldı.Tek değişkenli analizde Pearson Ki -kare analizi kullanıldı. P<0.05 istatistiksel olarak anlamlı kabul edildi.Bulgular: Toplam 103951 olgu incelendi. Bu olgulardan 257 tanesinde histopatolojik tanı GTH olarak belirlendi. 5 (%1.94) olguda koryokarsinom, 3 (%1.16) olguda ise plasental yerleşim bölgesinden gelişen trofoblastik tümör (PYBGTT) saptandı. 249 (%96) olguda ise tanı mol hidatiform (MH) idi. MH olgularının 136 (%52,9)'sı parsiyel, 113 (%43,9)'ü komplet mol olarak değerlendirildi. Tanı almış olan toplam 249 MH olgusunun %25'i (62) gerekli olan takiplerini yaptırmamıştır. Takipsizlik oranı parsiyel mol olgularında %21 (29/136), komplet mol hastalarında ise %25 (33/113) olarak belirlenmiştir. Sonuçlar: GTH olgularında programlanmış bir takip hastalığın yönetiminin temelini oluşturur ve hayati bir önem taşır. Hastaların uzmanlaşmış kliniklerde amaca uygun yönlendirilmeleri ile durumları hakkında daha sağlıklı bilgi sahibi oldukları ve gerekli olan takibe daha fazla uyum sağladıkları görülmektedir

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Cite This Article

TOSUN, Ö. A., BATU, P., ARINKAN³, L. A., YILMAZ, E., ÇAM, Ç., KARATEKE, A. (2012). Gestational trophoblastic disease and Follow-up Ratio. Zeynep Kamil Tıp Bülteni, Cilt: 43 - Sayı: 2, 53–57. https://ajindex.com/articles/335355

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