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Journals / Zeynep Kamil Tıp Bülteni / 2018 / Cilt: 49 - Sayı: 1

THE ROLE OF BIOCHEMICAL MARKERS OF FIRST TRIMESTER TRISOMY SCREENING TEST IN THE PREDICTION OF GESTATIONAL DIABETES MELLITUS

BİRİNCİ TRİMESTER TRİZOMİ TARAMA TESTİ BİYOKİMYASAL BELİRTEÇLERİNİN GESTASYONEL DİYABETES MELLİTUS ÖNGÖRÜSÜNDEKİ YERİ

Çiğdem YAYLA ABİDE
İlter YENİDEDE
ENİS ÖZKAYA
Pages
6–8
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, more patients and carefully planned prospective studies are needed in this subject.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate the potential advantage of routinely examined biochemical markers; PAPP-A (pregnancy related plasma protein A) and ßHCG values, in the first trimester screening test for the screening and early diagnosis of gestational diabetes mellitus (GDM) disease that occured in the following weeks of pregnancy without bringing any additional cost.Material and Method: This study was designed as a retrospective cohort study.
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Key Findings & Data:In this study singleton pregnancies were included whose first trimester trisomy screening tests were examined in our hospital and also deliviries of them took place in our hospital with the routine pregnancy follow up between January 2014 – December 2016.
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Conclusion & Impact:However, more patients and carefully planned prospective studies are needed in this subject.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Birinci trimester tarama · gestasyonel diyabetes mellitus · gebelik ilişkili protein A

Abstract

Objective: To investigate the potential advantage of routinely examined biochemical markers; PAPP-A (pregnancy related plasma protein A) and ßHCG values, in the first trimester screening test for the screening and early diagnosis of gestational diabetes mellitus (GDM) disease that occured in the following weeks of pregnancy without bringing any additional cost.Material and Method: This study was designed as a retrospective cohort study. In this study singleton pregnancies were included whose first trimester trisomy screening tests were examined in our hospital and also deliviries of them took place in our hospital with the routine pregnancy follow up between January 2014 – December 2016. The pregnancies were divided into two groups as GDM and control group. The functional role of biochemical markers ( PAPP-A (MoM), ßhcg (MoM)) in the first trimester screening test were investigated for early diagnosis of GDM which appeared in the later gestational weeks of pregnancy. Results: In the GDM group; maternal age, the number of pregnancies, parity, abort and living children were found significantly high, according to the control group (p<0.05). Statistically significant difference was not observed between PAPP-A (MoM), ßhcg (MoM), NT (mm) ve NT (MoM), gestational week of delivery, birth infant weight, APGAR 1.minute and APGAR 5.minute in the GDM group.Conclusion: No statistically significant relationship was established between biochemical markers of first trimester screening test and GDM in this study. However, more patients and carefully planned prospective studies are needed in this subject.

Özet

Amaç: Gebelere rutinde bakılan birinci trimester tarama testi biyokimyasal belirteçleri olan PAPP-A (Gebelik ilişkili plazma protein A) ve ßhcg değerlerinin, ilerleyen gebelik haftalarında gelişen gestasyonel diyabetes mellitus (GDM) hastalığının taranmasında ve erken tanısında ek maliyet yaratmadan faydalanabilme potansiyelini araştırmaktır. Materyal ve Metod: Bu çalışma retrospektif kohort bir çalışma olarak planlandı. Çalışmaya Ocak 2014 – Aralık 2016 yılları arasında birinci trimester trizomi taraması hastanemizde yapılan ve rutin gebelik takibine alınıp doğumunu yine hastanemizde gerçekleştirmiş olan tekil gebeler dahil edilmiştir. Gebeler GDM ve kontrol grubu olarak iki gruba ayrılmıştır. Birinci trimester tarama testi biyokimyasal belirteçlerinin ( PAPP-A (MoM), ßhcg (MoM)) ilerleyen gebelik haftalarında ortaya çıkan GDM’nin tanısının daha erken konulmasında rolünün etkisi araştırılmıştır. Bulgular: GDM grubunda, kontrol grubuna göre, anne yaşı, gebelik sayısı, parite, abortus ve yaşayan çocuk sayısı anlamlı olarak yüksek bulunmuştur (p<0.05). GDM grubunda PAPP-A (MoM), ßhcg (MoM), NT (mm) ve NT (MoM), doğumun gerçekleştiği gestasyonel hafta, bebek doğum ağırlığı, APGAR 1.dk ve APGAR 5.dk değerleri arasında istatistiksel olarak anlamlı bir fark gözlenmemiştir. Sonuç: Çalışmada birinci trimester tarama testi biyokimyasal belirteçleri ile GDM arasında istatistiksel olarak anlamlı bir ilişki saptanmamıştır. Ancak bu konuda daha çok hasta sayısı ve özenle planlanmış prospektif çalışmalara ihtiyaç duyulmaktadır.

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Cite This Article

ABİDE, Ç. Y., YENİDEDE, İ., ÖZKAYA, E. (2018). THE ROLE OF BIOCHEMICAL MARKERS OF FIRST TRIMESTER TRISOMY SCREENING TEST IN THE PREDICTION OF GESTATIONAL DIABETES MELLITUS. Zeynep Kamil Tıp Bülteni, Cilt: 49 - Sayı: 1, 6–8. https://ajindex.com/articles/335174

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References (11)

  1. Sweeting AN, Wong J, Appelblom H, Ross GP, Kouru H, Williams PF, et al. A first trimester prediction model for gestational diabetes utilizing aneuploidy and pre-eclampsia screening markers. J Matern Fetal Neonatal Med 2017:1–9. doi:10.1080/14767058.2017.1336759
  2. Sovio U, Murphy HR, Smith GCS. Accelerated Fetal Growth Prior to Diagnosis of Gestational Diabetes Mellitus: A Prospective Cohort Study of Nulliparous Women. Diabetes Care 2016;39:982–7. doi:10.2337/dc16-0160
  3. Logan KM, Emsley RJ, Jeffries S, Andrzejewska I, Hyde MJ, Gale C, et al. Development of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus. Diabetes Care 2016;39:1045–51. doi:10.2337/dc16-0030
  4. Nanda S, Singhal SR, Papneja A. Induction of labour with intravaginal misoprostol and prostaglandin E2 gel: a comparative study. Trop Doct 2007;37:21–4. doi:10.1258/004947507779952032
  5. Smith GCS. First trimester origins of fetal growth impairment. Semin Perinatol 2004;28:41–50
  6. Ong CY, Liao AW, Spencer K, Munim S, Nicolaides KH. First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. BJOG 2000;107:1265–70
  7. Husslein H, Lausegger F, Leipold H, Worda C. Association between pregnancy-associated plasma protein-A and gestational diabetes requiring insulin treatment at 11-14 weeks of gestation. J Matern Fetal Neonatal Med 2012;25:2230–3. doi:10.3109/14767058.2012.684170
  8. Lovati E, Beneventi F, Simonetta M, Laneri M, Quarleri L, Scudeller L, et al. Gestational diabetes mellitus: Including serum pregnancy-associated plasma protein-A testing in the clinical management of primiparous women? A case–control study. Diabetes Res Clin Pract 2013;100:340–7. doi:10.1016/j.diabres.2013.04.002
  9. Chelius D, Conover CA, Baldwin MA, Spencer EM. Characterization of the enzymatic specificity of the IGF-dependent insulin-like growth factor binding protein-4 (IGFBP-4) protease. Growth Horm IGF Res 2000;10:360–6. doi:10.1054/GHIR.2000.0177
  10. Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A 1999;96:3149–53. doi:10.1073/PNAS.96.6.3149
  11. Gomes MS, Carlos-Alves M, Trocado V, Arteiro D, Pinheiro P. Prediction of adverse pregnancy outcomes by extreme values of first trime