Significance of Pretreatment Testosterone Levels in Prostate Cancer Risk Groups

Conclusion: In conclusion, preoperative low TTE levels in patients who underwent RP were found to be associated with high-risk disease according to the D'Amico risk classification.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this report, patients, who had testosterone (TE) level data before prostate needle biopsy and who later underwent radical prostatectomy (RP) due to prostate adenocarcinoma, were evaluated.

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Key Findings & Data:The TE levels were analyzed in patients divided into three groups according to the D'Amico risk classification.Materials and Methods: Patients in the low-risk group constituted group 1, those in the intermediate-risk group-group 2 and subjects of the highrisk group were in group 3.

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Conclusion & Impact:Conclusion: In conclusion, preoperative low TTE levels in patients who underwent RP were found to be associated with high-risk disease according to the D'Amico risk classification.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: In this report, patients, who had testosterone (TE) level data before prostate needle biopsy and who later underwent radical prostatectomy (RP) due to prostate adenocarcinoma, were evaluated. The TE levels were analyzed in patients divided into three groups according to the D'Amico risk classification.Materials and Methods: Patients in the low-risk group constituted group 1, those in the intermediate-risk group-group 2 and subjects of the highrisk group were in group 3. Prostate specific antigen and TE levels, biopsy and RP pathological findings and biochemical recurrence rates were evaluated. Then all data were compared between the groups.Results: We evaluated 81 patients, whose data on TE level were available. Twenty eight patients were included in Group 1, 45 were in Group 2 and 8 were in Group 3. The mean follow-up time was 37.7 months. Total testosterone (GTE) levels were detected to be lower in Group 3 (p=0.033) than in patients of Group 1 and Group 2. However, pathological stage (p=0.004), Gleason score (p<0.001), tertiary Gleason pattern (p=0.032), tumor volume (p<0.001), surgical margins positivity (p=0.023), lymph node positivity (p=0.01) and biochemical recurrence (p=0.026) rates were found to be higher in Group 3. Conclusion: In conclusion, preoperative low TTE levels in patients who underwent RP were found to be associated with high-risk disease according to the D'Amico risk classification.

Özet

Amaç: Bu yazıda kliniğimizde prostat adenokarsinomu nedenli radikal prostatektomi (RP) yapılan hastalar arasından prostat iğne biyopsisi öncesi testosteron (TE) verileri olan hastalar değerlendirildi. D'Amico risk sınıflamasına göre gruplandırılan hastaların TE verileri araştırıldı. Gereç ve Yöntem: Prostat kanseri nedeni ile RP yapılan ve TE verileri olan hastalar D'Amico risk sınıflamasına göre üç grupta değerlendirildi. Düşük risk grubunda olan hastalar Grup 1, orta risk grubunda olan hastalar Grup 2 ve yüksek risk grubunda olan hastalar Grup 3 olarak adlandırıldı. Hastaların prostat spesifik antijen ve TE değerleri, biyopsi ve RP patoloji verileri ve biyokimyasal nüks oranları değerlendirildi. Mevcut veriler Grup 1, Grup 2 ve Grup 3 arasında karşılaştırılarak değerlendirildi. Bulgular: TE verileri olan 81 hasta değerlendirildi. Ortalama 37,7 ay izlemi olan hastalardan 28'i Grup 1'de, 45'i Grup 2'de ve 8'i Grup 3'teydi. Toplam TE (TTE) Grup 3'te düşük saptandı (p=0,033). RP patolojik evresi (p=0,004), Gleason skoru (p<0,001), tersiyer Gleason paterni (p=0,032), tümör hacmi (p<0,001), cerrahi sınır pozitifliği (p=0,023), lenf nodu pozitifliği (p=0,01) ve biyokimyasal nüks (p=0,026) oranları Grup 3'te yüksekti. Sonuç: Sonuç olarak RP öncesi D'Amico risk sınıflamasına göre değerlendirilen hastaların TTE düşüklüğünün yüksek riskli hastalıkla ilişkili olduğu saptanmıştır.

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Cite This Article

ÇELİK, S., BOZKURT, O., YILDIZ, H. A., DEMİR, Ö., TUNA, E. B., YÖRÜKOĞLU, K., ASLAN, G. (2016). Significance of Pretreatment Testosterone Levels in Prostate Cancer Risk Groups. Üroonkoloji Bülteni, Cilt: 15 - Sayı: 3, 98–102. https://ajindex.com/articles/334891

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References (11)

Kattan MW, Eastham JA, Stapleton AM, et al. A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer. J Natl Cancer Inst 1998;90:766-771.
Kattan MW, Wheeler TM, Scardino PT. Postoperative nomogram for disease recurrence after radical prostatectomy for prostate cancer. J Clin Oncol 1999;17:1499-1507.
Huland H, Hammerer P, Henke RP, Huland E. Preoperative prediction of tumor heterogeneity and recurrence after radical prostatectomy for localized prostatic carcinoma with digital rectal, examination prostate specific antigen and the results of 6 systematic biopsies. J Urol 1996;155:1344-1347.
Peller PA, Young DC, Marmaduke DP, et al. Sextant prostate biopsies. A histopathologic correlation with radical prostatectomy specimens. Cancer 1995;75:530-538. TTE: Total testosteron 0,018 Bozkurt O, Çelik S, Demir Ö, et al. Clinical Significance of Perineural Invasion in Prostate Needle Biopsy in Patients Diagnosed with Extraprostatic Extension and Seminal Vesicle Invasion after Radical Prostatectomy. Bulletin of Urooncology 2015;14:5-7.
DeLancey JO, Wood DP Jr, He C, et al. Evidence of perineural invasion on prostate biopsy specimen and survival after radical prostatectomy. Urology 2013;81:354-357.
Imamotoa T, Suzukia H, Fukasawa S, et al. Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy. Eur Urol 2005;47:308-312.
Ross PL, Scardino PT, Kattan MW. A catalog of prostate cancer nomograms. J Urol 2001;165:1562-1568.
Badalament RA, Miller MC, Peller PA, et al. An algorithm for predicting nonorgan confined prostate cancer using the results obtained from sextant core biopsies with prostate specific antigen level. J Urol 1996;156:1375-1380.
Ukimura O, Troncoso P, Ramirez EI, Babaian RJ. Prostate cancer staging: correlation between ultrasound determined tumor contact length and pathologically confirmed extraprostatic extension. J Urol 1998;159:1251-1259.
D'Amico AV, Whittington R, Malkowicz SB, et al. Combination of the preoperative PSA level, biopsy gleason score, percentage of positive biopsies, and MRI T-stage to predict early PSA failure in men with clinically localized prostate cancer. Urology 2000;55:572-577.
Partin AW, Kattan MW, Subong EN, et al. Combination of prostate- specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. JAMA 1997;277: