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Journals / Van Tıp Dergisi / 2017 / Cilt: 24 - Sayı: 4

Romatoid Artritli Bir Hastada Metotreksat Yüksek Doz Kullanımına Bağlı Toksisite: Olgu Sunumu

Sorumlu Yazar: Dr. Ömer Ekinci, Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı-Van

ALİ DOĞAN
ÖMER EKİNCİ
İsmet KIZILKAYA
Ergin TURGUT
Mehmet Maruf KAYRAN
CENGİZ DEMİR
Pages
378–381
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Especially for medications that require careful handling, appropriate training and detailed information should be given to patients and their relatives and patients should be frequently monitored

📌 3 Key Takeaways

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Objective & Hypothesis:Rheumatoid arthritis (RA) is a systemic inflammatory disease whose etiology is not fully known and is characterised by destruction of synovial membrane which is caused by inflammation in the joints and synovial cell proliferation.
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Key Findings & Data:In our case report, we presented a patient who accidentally took 15 mg/day MTX when was being treated with weekly based low-dose 15 mg/week MTX, as a result developed serious side effects such as pancytopenia and mucositis.
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Conclusion & Impact:Especially for medications that require careful handling, appropriate training and detailed information should be given to patients and their relatives and patients should be frequently monitored
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease whose etiology is not fully known and is characterised by destruction of synovial membrane which is caused by inflammation in the joints and synovial cell proliferation. Methotrexate (MTX) is one of diseasemodifying antirheumatic drugs (DMARDs) that is used at low doses and at weekly intervals in the treatment of rheumatoid arthritis. At high doses of MTX, toxicity such as bone marrow suppression, mucositis, liver and kidney dysfunction may occur. Pancytopenia and mucositis caused by methotrexate overdose can be treated with calcium folinate and filgrastim. In our case report, we presented a patient who accidentally took 15 mg/day MTX when was being treated with weekly based low-dose 15 mg/week MTX, as a result developed serious side effects such as pancytopenia and mucositis. Especially for medications that require careful handling, appropriate training and detailed information should be given to patients and their relatives and patients should be frequently monitored

Özet

Romatoid artrit (RA) etiyolojisi tam olarak bilinmeyen, eklemlerde sinoviyal hücre çoğalması ve inflamasyona bağlı eklem harabiyeti ile karakterize sistemik inflamatuar bir hastalıktır. Metotreksat (MTX) romatoid artrit tedavisinde düşük dozlarda ve haftalık periyotlarla kullanılan hastalık modifiye edici bir anti-romatizmal ajandır (DMARD). Yüksek dozlarda MTX kullanımına bağlı toksisite tablosu olarak kemik iliği süpresyonu, mukozit, karaciğer ve böbrek fonksiyon bozukluğu gibi ciddi yan etkiler ortaya çıkabilir. MTX'in toksik etkisi ile meydana gelen pansitopeni ve mukozit tablosu filgrastim ve kalsiyum folinat tedavisi ile düzeltilebilir. Düşük doz olarak haftalık 15 mg MTX kullanması gerekirken, yanlışlıkla günlük olarak 15 mg kullanmaya bağlı pansitopeni ile mukozit tablosu gelişen olgumuzu sunduk. Özellikle dikkatli kullanım gerektiren ilaçlar için hasta ve hasta yakınlarına uygun eğitim verilmesi ve hastaların sık aralıklı takibe alınması gerektiğine inanıyoruz

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Cite This Article

DOĞAN, A., EKİNCİ, Ö., KIZILKAYA, İ., TURGUT, E., KAYRAN, M. M., DEMİR, C. (2017). Romatoid Artritli Bir Hastada Metotreksat Yüksek Doz Kullanımına Bağlı Toksisite: Olgu Sunumu. Van Tıp Dergisi, Cilt: 24 - Sayı: 4, 378–381. https://ajindex.com/articles/334688

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