SavedAdd your journal

Journals / Üroonkoloji Bülteni / 2016 / Cilt: 15 - Sayı: 2

Association between Hormonal Evaluation Before Prostate Needle Biopsy and Locally Advanced Prostate Cancer

Prostat İğne Biyopsisi Öncesi Hormonal Değerlendirme ile Lokal İleri Prostat Kanseri Arasındaki İlişki

Serdar ÇELİK
OZAN BOZKURT
Hüseyi̇n Alperen YILDIZ
Ömer DEMİR
EMİNE BURÇİN TUNA
KUTSAL YÖRÜKOĞLU
Güven ASLAN
Pages
52–56
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Tumor volume (p=0.004), surgical margin positivity (p=0.022) and biochemical recurrence (p<0.001) rates from postoperative data were found to be higher in group 2, as well.Conclusion: In conclusion, higher rates of EST and FSH/LH values determined by hormonal evaluation before prostate needle biopsy were found to be associated with high-stage tumor, high surgical margin positivity and high biochemical recurrence after RRP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In this study, patients hormonally evaluated before prostate needle biopsy were considered among the ones who underwent radical prostatectomy (RRP) due to prostate adenocarcinoma and had locally advanced pathological stage (T3).
📊
Key Findings & Data:Patients with T3a and T3b pathological stages were evaluated as group 1 and group 2, respectively.
💡
Conclusion & Impact:Tumor volume (p=0.004), surgical margin positivity (p=0.022) and biochemical recurrence (p<0.001) rates from postoperative data were found to be higher in group 2, as well.Conclusion: In conclusion, higher rates of EST and FSH/LH values determined by hormonal evaluation before prostate needle biopsy were found to be associated with high-stage tumor, high surgical margin positivity and high biochemical recurrence after RRP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, patients hormonally evaluated before prostate needle biopsy were considered among the ones who underwent radical prostatectomy (RRP) due to prostate adenocarcinoma and had locally advanced pathological stage (T3). The relationship between pathology results and cancer prognosis with hormonal data was investigated in these patients.Materials and Methods: Patients with hormonal data and those who were diagnosed with locally advanced prostate cancer were evaluated in two groups. Patients with T3a and T3b pathological stages were evaluated as group 1 and group 2, respectively. Prostate specific antigen (PSA), free PSA (fPSA), total testosterone (TTE), free testosterone (FTE), luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol (EST) values of patients were examined. Prostate needle biopsy pathological data, prostate volume (PV), clinical stage, RRP pathological data, pathological stage, surgical margins and lymph node positivity and biochemical recurrence rates of patients were also evaluated. Then fPSA/PSA, PSA/PV, TTE/PV, TTE/FTE, TTE/LH, FSH/LH, TTE/FSH and TTE/EST ratios were calculated from the hormonal data. Finally, all data were compared between group 1 and group 2.Results: Thirty-two patients with hormonal data were retrospectively evaluated. Patient mean follow-up time was 31.9 months and there were 24 patients in group 1 and 8 patients in group 2. EST (p=0.05) and FSH/LH (p=0.044) values were identified to be higher in group 2. Also, prostate biopsy Gleason score (p=0.026) and perineural invasion positivity (p=0.024) were higher in group 2. Tumor volume (p=0.004), surgical margin positivity (p=0.022) and biochemical recurrence (p<0.001) rates from postoperative data were found to be higher in group 2, as well.Conclusion: In conclusion, higher rates of EST and FSH/LH values determined by hormonal evaluation before prostate needle biopsy were found to be associated with high-stage tumor, high surgical margin positivity and high biochemical recurrence after RRP. Therefore, hormonal evaluation can be used as a predictor of locally advanced disease.

Özet

Amaç: Bu çalışmada kliniğimizde prostat adenokarsinomu nedeni ile radikal prostatektomi (RRP) yapılan ve lokal ileri evre (T3) saptanan hastalar arasından prostat iğne biyopsisi öncesi hormonal değerlendirmesi mevcut hastalar değerlendirildi. Bu hastaların patoloji sonuçları ve hastalık prognozu ile hormonal değerler arasındaki ilişki araştırıldı. Gereç ve Yöntem: Hormonal verileri olan ve patolojik olarak lokal ileri evre prostat kanseri saptanan hastalar iki grupta değerlendirildi. Patolojik T3a hastalar grup 1, T3b hastalar ise grup 2 olarak adlandırıldı. Hastaların prostat spesifik antijen (PSA), serbest PSA (sPSA), total testosteron (TTE), serbest testosteron (STE), lüteinizan hormon (LH), folikül stimüle edici hormon (FSH) ve estradiol (EST) değerleri incelendi. Prostat iğne biyopsi patoloji verileri, prostat volümü (PV), klinik evresi, RRP patoloji verileri, patolojik evresi, cerrahi sınır ve lenf nodu pozitiflikleri ile biyokimyasal nüks oranları değerlendirildi. Sonrasında sPSA/PSA, PSA/PV, TTE/PV, TTE/ STE, TTE/LH, FSH/LH, TTE/FSH ve TTE/EST oranları hesaplandı. Son olarak mevcut veriler grup 1 ve grup 2 arasında karşılaştırıldı. Bulgular: Hormonal verileri olan 32 hasta retrospektif olarak değerlendirildi. Ortalama 31,9 ay izlemi mevcut hastalardan 24'ü grup 1'de, 8'i grup 2'deydi. EST (p=0,05) ve FSH/LH (p=0,044) grup 2'de yüksek saptandı. Ayrıca prostat biyopsi Gleason skoru (p=0,026) ve perinöral invazyon pozitifliği (p=0,024) grup 2'de daha yüksekti. Postoperatif verilerden tümör hacmi (p=0,004), cerrahi sınır pozitifliği (p=0,022) ve biyokimyasal nüks (p<0,001) oranları da yine grup 2'de yüksek saptandı. Sonuç: Sonuç olarak prostat iğne biyopsisi öncesi hormonal değerlendirme ile saptanan EST ve FSH/LH oranı yüksekliğinin RRP'den sonra yüksek evreli tümör, cerrahi sınır pozitifliği ve biyokimyasal nüks ile ilişkili olduğu saptanmıştır. Bu nedenle hormonal değerlendirmeler lokal ileri hastalığı öngörmede kullanılabilir.

🔖

Cite This Article

ÇELİK, S., BOZKURT, O., YILDIZ, H. A., DEMİR, Ö., TUNA, E. B., YÖRÜKOĞLU, K., ASLAN, G. (2016). Association between Hormonal Evaluation Before Prostate Needle Biopsy and Locally Advanced Prostate Cancer. Üroonkoloji Bülteni, Cilt: 15 - Sayı: 2, 52–56. https://ajindex.com/articles/334447

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Lu-Yao GL, Potosky AL, Albertsen PC, et al. Follow-up prostate cancer treatments after radical prostatectomy: a population-based study. J Natl Cancer Inst 1996;88:166-173.
  2. Partin AW, Kattan MW, Subong EN, et al. Combination of prostate- specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. JAMA 1997;277:1445-1451.
  3. Huland H, Hammerer P, Henke RP, Huland E. Preoperative prediction of tumor heterogeneity and recurrence after radical prostatectomy for localized prostatic carcinoma with digital rectal, examination prostate specific antigen and the results of 6 systematic biopsies. J Urol 1996;155:1344-1347.
  4. Peller PA, Young DC, Marmaduke DP, et al. Sextant prostate biopsies. A histopathologic correlation with radical prostatectomy specimens. Cancer 1995;75:530-538.
  5. Bozkurt O, Çelik S, Demir Ö, et al. Clinical significance of perineural invasion in prostate needle biopsy in patients diagnosed with extraprostatic extension and seminal vesicle invasion after radical prostatectomy. Bulletin of Urooncology 2015;14:5-7.
  6. DeLancey JO, Wood DP Jr, He C, et al. Evidence of perineural invasion on prostate biopsy specimen and survival after radical prostatectomy. Urology 2013;81:354-357.
  7. Ross PL, Scardino PT, Kattan MW. A catalog of prostate cancer nomograms. J Urol 2001;165:1562-1568.
  8. Ide H, Terado Y, Sakamaki K, et al. Serum level of follicle-stimulating hormone is associated with extraprostatic extension of prostate cancer. Prostate Int 2013;1:109-112.
  9. Chodak GW, Vogelzang NJ, Caplan RJ, et al. Independent prognostic factors in patients with metastatic (stage D2) prostate cancer. The Zoladex Study Group. JAMA 1991;265:618-621.
  10. Ribeiro M, Ruff P, Falkson G. Low serum testosterone and a younger age predictfor a poor outcome in metastatic prostate cancer. Am J Clin Oncol 1997;20:605-608.
  11. Huggins C, Stevens RE, Hodges CV. Studies on prostatic cancer: II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 1941;43:209. English HF, Kloszewski ED, Valentine EG, Santen RJ. Proliferative response of the Dunning R3327H experimental model of prostatic adenocarcinoma to conditions of androgen depletion and repletion. Cancer Res 1986;46:839-844.
  12. Chen SS, Chen KK, Lin AT, et al. The correlation between pretreatment serum hormone levels and treatment outcome for patients with prostatic cancer and bony metastasis. BJU Int 2002;89:710-713.
  13. Iversen P, Rasmussen F, Christen